Mentoring Clinical Researchers at the Intersection of NeuroHIV and Substance Abuse

指导神经艾滋病毒和药物滥用交叉点的临床研究人员

• 批准号: 10642839
• 负责人: MARIANA CHERNER
• 金额: $ 19.19万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642839
• 关键词: Accounting; Affect; Anti-Inflammatory Agents; Antioxidants; Award; Biological Markers; Brain; COVID-19; COVID-19 impact; California; Cannabidiol; Cannabinoids; Career Mobility; Central Nervous System; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Communicable Diseases; Communities; Complex; Computerized Medical Record; Creativeness; Data; Development; Doctor of Philosophy; Dopamine; Elderly; Environment; Evaluation; Fellowship; Fostering; Functional disorder; Funding; Funding Opportunities; Future; Goals; HIV; HIV Infections; Hispanic; Hispanic Populations; Hospitalization; Impairment; Impulsive Behavior; Individual Differences; Inflammation; Inflammatory; Interdisciplinary Study; Knowledge; Latino Population; Leadership; Learning; Medical; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Mitochondria; Nature; Neurocognition; Neurocognitive; Neuropsychology; Oils; Oral; Outcome; Oxidative Stress; Pathology; Patients; Persons; Plasma; Population; Postdoctoral Fellow; Problem Solving; Process; Property; Psychiatry; Psychology; Publications; Regulation; Research; Research Ethics; Research Infrastructure; Research Methodology; Research Personnel; Research Support; Risk Behaviors; Role; SARS-CoV-2 infection; Scientist; Sorbus; Source; Specimen; Substance abuse problem; Training; Training Programs; Training and Education; Translational Research; Universities; Virus Replication; Work; addiction; biopsychosocial; career; cocaine exposure; computational neuroscience; disadvantaged background; early-career faculty; experience; faculty mentor; health disparity; immune activation; immunoregulation; improved; insight; interdisciplinary collaboration; interest; mid-career faculty; neuroAIDS; neurobehavioral; neuropsychiatry; patient oriented; patient oriented research; post-COVID-19; professor; programs; skills; stimulant use; substance use; translational approach

Project Summary This is a renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research to support my ability (1) to attract scientists to patient-oriented research at the intersection of neuroHIV and substance use, (2) to prepare a new crop of investigators to tackle complex research questions that require translational approaches and interdisciplinary collaboration, and (3) to diversify the composition of the scientific workforce in order to increase creativity, insights, and representation of problem-solving approaches. Mentoring and training will be integrally tied to my own research and to the major projects within the HIV Neurobehavioral Research Program (HNRP) at the University of California, San Diego, which are rich sources of data, specimens, and research infrastructure. Mentees will also have access to didactics made available by training programs in which I participate, such as the R25 Interdisciplinary Research Fellowship in NeuroAIDS, which I direct, and a T32 program for Training in Research on Addictions in Interdisciplinary NeuroAIDS, where I am a faculty mentor. I plan to involve mentees in developing new research directions in medical applications of cannabinoids for neuroHIV and explore predictors of central nervous system outcomes in Latinos who recover from COVID-19. I will also involve mentees in my continued work on individual differences in vulnerability to CNS dysfunction associated with stimulant use in the context of HIV. I propose additionally to pursue my own professional development to continue to improve my skill set in mentoring trainees from underrepresented and disadvantaged backgrounds, as well as to enhance my leadership skills. The superb research environment of the HNRP, along with the larger UCSD HIV and substance use research community, affords excellent opportunities for mentoring and fostering the advancement of early career clinically oriented scientists.

项目总结

项目成果

HIV Antiretroviral Medication Neuropenetrance and Neurocognitive Outcomes in HIV+ Adults: A Review of the Literature Examining the Central Nervous System Penetration Effectiveness Score.

HIV抗逆转录病毒药物的神经培训和HIV+成人的神经认知结果：研究中枢神经系统渗透有效性评分的文献综述。

• DOI: 10.3390/v14061151
• 发表时间: 2022-05-26
• 期刊: Viruses

COMT val158met genotype alters the effects of methamphetamine dependence on dopamine and dopamine-related executive function: preliminary findings.

• DOI: 10.1016/j.psychres.2020.113269
• 发表时间: 2020-10
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Saloner R;Cherner M;Sundermann EE;Watson CW;Iudicello JE;Letendre SL;Kumar A;Ellis RJ
• 通讯作者: Ellis RJ

SNP genotyping using TaqMan technology: the CYP2D6*17 assay conundrum.

• DOI: 10.1038/srep09257
• 发表时间: 2015-03-19
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Gaedigk A;Freeman N;Hartshorne T;Riffel AK;Irwin D;Bishop JR;Stein MA;Newcorn JH;Jaime LK;Cherner M;Leeder JS
• 通讯作者: Leeder JS