Mentoring Clinical Researchers at the Intersection of NeuroHIV and Substance Abuse

项目摘要 这是一份K24中期职业研究者以患者为导向的研究奖的续期申请，以支持 我的能力（1）吸引科学家在神经艾滋病病毒和物质使用的交叉点上进行以病人为导向的研究， (2)准备一批新的研究人员来解决复杂的研究问题， 方法和跨学科合作，以及（3）使科学劳动力的组成多样化， 以提高创造力，洞察力，并代表解决问题的方法。辅导和培训 我将与我自己的研究和艾滋病神经行为研究的主要项目紧密联系在一起 计划（HNRP）在加州，圣地亚哥大学，这是丰富的数据来源，标本， 研究基础设施。学员还将获得培训方案提供的教学方法， 我参加，如R25跨学科研究奖学金在神经艾滋病，我指导，和T32 在跨学科的神经艾滋病成瘾研究培训计划，我是一个教师导师。我 计划让学员参与开发大麻素医学应用的新研究方向， neuroHIV和探索从COVID-19中康复的拉丁美洲人的中枢神经系统结果的预测因素。我 我还将让学员参与我继续研究CNS功能障碍易感性的个体差异的工作 与艾滋病患者使用兴奋剂有关。我还打算追求我自己的专业 发展，以继续提高我在指导来自代表性不足和弱势群体的学员方面的技能 背景，以及提高我的领导能力。HNRP一流的研究环境，沿着 与更大的UCSD艾滋病毒和物质使用研究社区，提供了很好的机会，指导 并促进早期职业临床导向科学家的进步。

Project Summary This is a renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research to support my ability (1) to attract scientists to patient-oriented research at the intersection of neuroHIV and substance use, (2) to prepare a new crop of investigators to tackle complex research questions that require translational approaches and interdisciplinary collaboration, and (3) to diversify the composition of the scientific workforce in order to increase creativity, insights, and representation of problem-solving approaches. Mentoring and training will be integrally tied to my own research and to the major projects within the HIV Neurobehavioral Research Program (HNRP) at the University of California, San Diego, which are rich sources of data, specimens, and research infrastructure. Mentees will also have access to didactics made available by training programs in which I participate, such as the R25 Interdisciplinary Research Fellowship in NeuroAIDS, which I direct, and a T32 program for Training in Research on Addictions in Interdisciplinary NeuroAIDS, where I am a faculty mentor. I plan to involve mentees in developing new research directions in medical applications of cannabinoids for neuroHIV and explore predictors of central nervous system outcomes in Latinos who recover from COVID-19. I will also involve mentees in my continued work on individual differences in vulnerability to CNS dysfunction associated with stimulant use in the context of HIV. I propose additionally to pursue my own professional development to continue to improve my skill set in mentoring trainees from underrepresented and disadvantaged backgrounds, as well as to enhance my leadership skills. The superb research environment of the HNRP, along with the larger UCSD HIV and substance use research community, affords excellent opportunities for mentoring and fostering the advancement of early career clinically oriented scientists.