Mentoring Clinical Researchers at the Intersection of NeuroHIV and Substance Abuse

项目摘要 这是对以患者为中心的研究的K24职业中期研究员奖的续签申请，以支持 我的能力(1)吸引科学家在神经艾滋病毒和物质使用的交叉点进行以患者为导向的研究， (2)准备一批新的研究人员，以解决需要翻译的复杂研究问题 方法和跨学科协作，以及(3)使#年科学队伍的构成多样化 以增加创造性、洞察力和问题解决方法的代表性。指导和培训 将与我自己的研究和HIV神经行为研究中的主要项目紧密相连 加州大学圣地亚哥分校的HNRP计划(HNRP)提供了丰富的数据、样本和 研究基础设施。学员还将获得通过培训计划提供的教学内容， 我参与了R25神经艾滋病跨学科研究奖学金，这是我的指导，还有一个T32 跨学科神经艾滋病成瘾研究培训计划，在那里我是一名教员导师。我 计划让学员参与开发大麻类药物医疗应用的新研究方向 并探索新冠肺炎康复者中拉美人中枢神经系统预后的预测因素。我 我还将让被指导者参与我关于中枢神经系统功能障碍易感性的个体差异的持续工作 与艾滋病毒背景下的兴奋剂使用有关。我还建议追求我自己的专业 发展以继续提高我在指导来自代表不足和处境不利的学员方面的技能 背景，以及提高我的领导能力。HNRP一流的研究环境，沿着 与加州大学圣迭戈分校更大的艾滋病毒和物质使用研究社区一起，为指导提供了极好的机会 促进以临床为导向的早期职业科学家的进步。

Project Summary This is a renewal application for a K24 Midcareer Investigator Award in Patient-Oriented Research to support my ability (1) to attract scientists to patient-oriented research at the intersection of neuroHIV and substance use, (2) to prepare a new crop of investigators to tackle complex research questions that require translational approaches and interdisciplinary collaboration, and (3) to diversify the composition of the scientific workforce in order to increase creativity, insights, and representation of problem-solving approaches. Mentoring and training will be integrally tied to my own research and to the major projects within the HIV Neurobehavioral Research Program (HNRP) at the University of California, San Diego, which are rich sources of data, specimens, and research infrastructure. Mentees will also have access to didactics made available by training programs in which I participate, such as the R25 Interdisciplinary Research Fellowship in NeuroAIDS, which I direct, and a T32 program for Training in Research on Addictions in Interdisciplinary NeuroAIDS, where I am a faculty mentor. I plan to involve mentees in developing new research directions in medical applications of cannabinoids for neuroHIV and explore predictors of central nervous system outcomes in Latinos who recover from COVID-19. I will also involve mentees in my continued work on individual differences in vulnerability to CNS dysfunction associated with stimulant use in the context of HIV. I propose additionally to pursue my own professional development to continue to improve my skill set in mentoring trainees from underrepresented and disadvantaged backgrounds, as well as to enhance my leadership skills. The superb research environment of the HNRP, along with the larger UCSD HIV and substance use research community, affords excellent opportunities for mentoring and fostering the advancement of early career clinically oriented scientists.