Interdisciplinary Research Fellowship in NeuroAIDS

神经艾滋病跨学科研究奖学金

• 批准号: 10630904
• 负责人: MARIANA CHERNER
• 金额: $ 17.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630904
• 关键词: Acquired Immunodeficiency Syndrome; Advisory Committees; Area; Basic Science; Behavioral; Brain; Caliber; Central Nervous System; Clinical; Clinical Sciences; Communicable Diseases; Competence; Complex; Consequences of HIV; Crystallization; Dedications; Development; Discipline; Education; Educational Curriculum; Educational Models; Educational process of instructing; Environment; Epidemic; Evaluation; Extramural Activities; Faculty; Fellowship; Funding; Future; Genetic; Grant; HIV; HIV Infections; Health Care Costs; Health Priorities; Home; Immersion; Immunology; Individual; Individuation; Interdisciplinary Study; International; Knowledge; Laboratories; Learning; Left; Link; Mentors; Mentorship; Mining; Modality; Modernization; Molecular; Molecular Biology; National Institute of Mental Health; Neuropsychology; Neurosciences; Participant; Pathologic Processes; Pilot Projects; Postdoctoral Fellow; Problem Solving; Public Health; Recording of previous events; Research; Research Ethics; Research Infrastructure; Research Personnel; Research Priority; Research Training; Resources; Science; Scientist; Structure; Talents; Technology; Thinking; Training; Translational Research; United States National Institutes of Health; Virus Replication; Work; Writing; base; brain health; career; clinical application; design; education planning; education research; equity, diversity, and inclusion; evidence base; experience; flexibility; interdisciplinary approach; interest; lectures; life-long learning; multidisciplinary; neuroAIDS; neurobehavioral; neuroimaging; neuropathology; patient oriented; phenomenological models; pre-clinical; programs; recruit; skills; success; translational approach; translational goal; translational model; virology

SUMMARY The Interdisciplinary Research Fellowship in NeuroHIV (IRFN) is a two-year research education program anchored on the premise that our future success in tackling the complexity of clinical problems in neuroHIV depends on the availability of researchers with the training to imagine problem-solving approaches that cut- across and integrate multiple relevant research disciplines. To this end, we have followed an interdisciplinary and translational model of research training aimed at bridging the gaps left by single discipline approaches. Our program functions as a neuroHIV-themed Special Institute emphasizing interdisciplinary and translational research through immersion into the vibrant research setting of the HIV Neurobehavioral Research Program (HNRP) and two main programmatic components: mentored research and focused didactics. Participants receive close mentoring by experts in the field, leveraging the expertise of preclinical and clinically oriented neuroHIV researchers. The IRFN outlines a clear progression toward independence in order to consolidate each Fellow’s future success. Participants learn to approach neuroHIV research questions from an interdisciplinary and translational perspective, with potential clinical applications as an essential end point of their work. In the proposed renewal we will equally engage clinically trained as well as basic postdoctoral and early career neuroscientists seeking to apply their talents to research on patient-oriented problems in neuroHIV. This serves our translational goals by engendering “cross-pollination” of ideas. The research experiences of IRFN fellows will be in the laboratories of high-caliber, nationally and internationally recognized neuroHIV researchers. Core competencies will cover current thinking in NeuroHIV, from molecular to behavioral phenomena, general research principles, research ethics, and grant writing skills. Essentials of good mentoring will also be taught formally using evidence-based curricula. Additional didactics will center on professional development and electives to enhance participants’ knowledge and individuation in areas of interest. Principles of equity, diversity, and inclusion will be upheld across all components of the IRFN. Proposed for this renewal is the introduction of seed funding for Fellows to conduct a focused, vetted pilot project in an area aligned with NIMH HIV research priorities and the research themes within the HNRP, with the aim of facilitating a future extramural funding application. The IRFN features: (1) outstanding faculty who have a long history of mentoring researchers to become independent investigators, (2) individualized education, including research experiences that are tailored to individual needs, (3) core and flexible didactic experiences, including lectures by leading neuroHIV researchers, and (4) active evaluation and oversight of the program by a multidisciplinary advisory committee.

摘要 神经艾滋病毒跨学科研究奖学金是一个为期两年的研究教育项目 基于这样一个前提，即我们未来在解决神经性艾滋病毒临床问题的复杂性方面取得的成功 取决于受过培训的研究人员能否想象出解决问题的方法，从而减少- 跨越和整合多个相关研究学科。为此，我们遵循了一种跨学科的 以及旨在弥合单一学科方法留下的差距的研究培训的翻译模式。我们的 该计划作为一个以神经艾滋病毒为主题的特别研究所，强调跨学科和翻译 通过沉浸在充满活力的艾滋病毒神经行为研究计划的研究环境中进行研究 (HNRP)和两个主要的方案组成部分：指导性研究和重点教学。参与者 接受该领域专家的密切指导，利用临床前和临床导向的专业知识 神经艾滋病毒研究人员。IRFN勾勒出了一个明确的独立进程，以巩固每个 菲尔未来的成功。参与者学习从跨学科的角度处理神经艾滋病毒研究问题 和翻译视角，将潜在的临床应用作为他们工作的重要终点。在 拟议的续签将平等地聘用临床培训的以及基本的博士后和早期职业 寻求将他们的才华应用于研究以患者为中心的神经艾滋病毒问题的神经科学家。这是服务 我们的翻译目标是通过产生思想的“异花授粉”。IRFN研究员的研究心得 将在高素质、国内和国际公认的神经艾滋病毒研究人员的实验室中进行。堆芯 能力将涵盖神经艾滋病毒的当前思维，从分子到行为现象，一般 研究原则、研究道德和授权书写作技巧。此外，还将教授良好指导的要领 正式使用循证课程。其他教学将集中在职业发展和 提高学员在感兴趣领域的知识和个性化程度的选修课。公平、多样性、 并将在IRFN的所有组成部分中坚持纳入。这次更新的建议是引入 为研究员提供种子资金，以在与NIMH艾滋病毒研究相一致的领域开展有重点的、经过审查的试点项目 HNRP内的优先事项和研究主题，目的是促进未来的外部资金 申请。IRFN的特点是：(1)具有长期指导研究人员的杰出教职员工 成为独立调查人员，(2)个性化教育，包括量身定做的研究经验 根据个人需要，(3)核心和灵活的教学体验，包括领导神经艾滋病毒的讲座 研究人员，以及(4)多学科咨询委员会对该计划的积极评估和监督。

项目成果

Antiretroviral Levels in the Cerebrospinal Fluid: The Effect of Inflammation and Genetic Variants.

• DOI: 10.3390/diagnostics13020295
• 发表时间: 2023-01-12
• 期刊: DIAGNOSTICS
• 影响因子: 3.6
• 作者: Cusato, Jessica;Avataneo, Valeria;Antonucci, Miriam;Trunfio, Mattia;Marinaro, Letizia;Palermiti, Alice;Manca, Alessandra;Di Perri, Giovanni;Mula, Jacopo;Bonora, Stefano;D'Avolio, Antonio;Calcagno, Andrea
• 通讯作者: Calcagno, Andrea

Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine.

• DOI: 10.1097/fbp.0000000000000012
• 发表时间: 2014-02
• 期刊: Behavioural pharmacology
• 影响因子: 1.6
• 作者: Henry BL;Geyer MA;Buell MR;Perry W;Young JW;Minassian A;Translational Methamphetamine AIDS Research Center (TMARC) Group
• 通讯作者: Translational Methamphetamine AIDS Research Center (TMARC) Group

Protective effects of higher cognitive reserve for neuropsychological and daily functioning among individuals infected with hepatitis C.

• DOI: 10.1007/s13365-013-0196-4
• 发表时间: 2013-10
• 期刊: JOURNAL OF NEUROVIROLOGY
• 影响因子: 3.2
• 作者: Sakamoto, Maiko;Woods, Steven Paul;Kolessar, Michael;Kriz, Daniel;Anderson, J. Renee;Olavarria, Hannah;Sasaki, Anna W.;Chang, Michael;Flora, Kenneth D.;Loftis, Jennifer M.;Huckans, Marilyn
• 通讯作者: Huckans, Marilyn

Craving among patients seeking treatment for substance use disorder.

• DOI: 10.1007/s44192-023-00049-y
• 发表时间: 2023-11-08
• 期刊: Discover mental health

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.

• DOI: 10.1083/jcb.201612067
• 发表时间: 2017-04-03
• 期刊: The Journal of cell biology
• 作者: Divakaruni AS;Wallace M;Buren C;Martyniuk K;Andreyev AY;Li E;Fields JA;Cordes T;Reynolds IJ;Bloodgood BL;Raymond LA;Metallo CM;Murphy AN
• 通讯作者: Murphy AN