1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India

1/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-印度

• 批准号: 10643868
• 负责人: Dorairaj Prabhakaran
• 金额: $ 30.48万
• 依托单位: CENTRE FOR CHRONIC DISEASE CONTROL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643868
• 关键词: Acceleration; Address; Adolescence; Adolescent; Adult; Advisory Committees; Affect; Aging; Air Pollutants; Air Pollution; Anthropometry; Area; Birth; Blood Pressure; Carbon; Cardiovascular Diseases; Cardiovascular system; Child; Childhood; Chronic; Chronic Disease; Complex; Country; Cross-Sectional Studies; DNA Methylation; Data; Development; Diameter; Disease; Education; Elderly; Elements; Environmental Exposure; Environmental Health; Epigenetic Process; Future; Gender; Genomic Segment; Gestational Diabetes; Glucose; Grant; Growth; Health; Human Resources; Hypertension; Impaired cognition; Incidence; Income; India; Individual; Inequality; Infrastructure; Insulin; Intervention; Joints; Level of Evidence; Life; Life Cycle Stages; Link; Location; Long-Term Effects; Longevity; Low Birth Weight Infant; Measurement; Measures; Mediating; Mentors; Metabolism; Metals; Meteorology; Modeling; Modification; Monitor; Myocardial Infarction; Nerve Degeneration; Nitrogen Dioxide; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Ozone; Participant; Particulate Matter; Pattern; Physical Performance; Policies; Pollution; Population; Populations at Risk; Pre-Eclampsia; Predisposition; Pregnancy; Pregnancy Complications; Premature Birth; Public Health; Research; Research Support; Research Training; Resolution; Retrospective Studies; Risk; Role; Rural; Sampling; Scanning; Science; Scientist; Socioeconomic Status; Temperature; Testing; Time; Training; Vulnerable Populations; Work; adverse birth outcomes; age related; arterial stiffness; cognitive development; cohort; early childhood; epigenome; experience; extreme temperature; frailty; human old age (65+); improved; indexing; infancy; infrastructure development; land use; low and middle-income countries; machine learning prediction; methylation pattern; mortality; muscle strength; novel strategies; predictive modeling; programs; sex; socioeconomics; spatiotemporal; therapy design; urban setting

Project Summary Air pollution represents a major public health threat in India, affecting a quarter of the country’s population at extreme levels. The evidence on health impacts of air pollution, which mainly comes from high income countries, is not transferable to LMICs like India with complex urban environments and high pollution levels. The proposal entitled “1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India” builds on the research and infrastructure established in the ongoing (to be completed on 7/30/2021), Air pollution and Health GEOHealth Program. In the current proposal we aim to extend our exposure assessments to include a range of air pollutants: particulate matter with aerodynamic diameter <2.5m (PM2.5), nitrogen dioxide (NO2) and ozone (O3), and extremes of temperature to assess the exposomes at fine spatiotemporal resolutions across different locations in India (Delhi, Chennai, Sonipat, Vizag, Pune, Hyderabad and Bikaner). Additionally, we will evaluate the composition of PM2.5 in these locations and measure real time exposures in a subset of the participants. These exposomes will be related to a range of chronic non- communicable diseases across the life course using inter-digitating cohorts. This will be achieved by leveraging existing pregnancy, children, adult, and older adult cohorts across India. This will help us systematically assess the vulnerable populations across pregnancy, infancy, childhood, adolescence, adult and older adult groups. We will also address how environmental exposomes interact with gender, socio-economic status, rural-urban settings, and pre-existing illnesses in impacting the health outcomes. Further, we will replicate the findings from our epigenome-wide scan (from the ongoing study) in larger set of samples to validate DNA methylation profiles associated with incident myocardial infarction and explore if these epigenetic mechanisms mediate the effect of exposomes on myocardial infarction. Through this joint application, we will accelerate scientific infrastructure development, enhance research training to support research needed to characterize the relationship between environmental exposomes and health outcomes across the lifespan in India. The study will be led by Dr. Prabhakaran from CCDC and Dr. Reddy from PHFI and Dr. Schwartz and Dr. Sieber from HSPH, who will be assisted by the: 1) External Advisory Committee; 2) Administrative Oversight Committee; 3) Training Oversight Committee; 4) Program coordination personnel at HSPH and CCDC; and 5) Supervisory teams for individual trainees (Indian & HSPH mentors). The proposed study findings will identify the policy reforms needed to address the growing burden of air pollution and protect the large at-risk population. The training of the Indian scientists in the linked U2R in the area of environmental health will build capacity to undertake relevant studies and apply for future grants to address the threat from adverse environmental exposures in India.

项目摘要 空气污染是印度的主要公共卫生威胁，影响该国四分之一的人口 极端水平。关于空气污染的健康影响的证据，主要来自高收入国家， 没有转移到像印度这样的LMIC，具有复杂的城市环境和高污染水平。提案 题为“ 1/2- geohealth的健康效果 （治愈） - 印度”建立在正在进行中建立的研究和基础设施的基础上（要完成 7/30/2021），空气污染和健康地质健康计划。在当前的建议中，我们旨在扩大我们的曝光率 评估以包括一系列空气污染物：空气直径<2.5毫米（PM2.5）的特定物质， 二氧化氮（NO2）和臭氧（O3），以及温度的极端，以评估细胞体的爆炸体 跨印度不同地点的时空分辨率（德里，钦奈，索尼帕特，维萨格，浦那，海得拉巴 和Bikaner）。此外，我们将在这些位置评估PM2.5的组成并测量实时 在参与者的一部分中暴露。这些暴露将与一系列慢性非 - 使用相互依赖的人群在整个生活课程中进行交流疾病。这将通过利用 印度的现有怀孕，儿童，成人和老年人群。这将有助于我们系统地评估 怀孕，婴儿期，童年，青少年，成人和老年人的脆弱人群。我们 还将解决环境展开体如何与性别相互作用，社会经济地位，农村城市 环境，以及影响健康结果的疾病。此外，我们将从 我们在较大样品中扫描我们的表观基因组扫描（从正在进行的研究中），以验证DNA甲基化曲线 与事件心肌梗塞相关并探索这些表观遗传机制是否介导 心肌违规的外博。通过此联合应用，我们将加速科学基础设施 开发，增强研究培训，以支持表征所需的研究 印度整个生命周期的环境展开体和健康成果。该研究将由博士领导。 来自CCDC的Prabhakaran和PHFI的Reddy博士，Schwartz博士和HSPH的Sieber博士，他们将成为 在：1）外部咨询委员会的协助下； 2）行政监督委员会； 3）培训监督 委员会; 4）HSPH和CCDC的计划协调人； 5）个人监督团队 学员（印度和HSPH导师）。拟议的研究结果将确定解决问题的政策改革 空气污染的燃烧日益严重并保护大量的高危人群。印度科学家的培训 在环境健康领域的链接U2R中，将建立进行相关研究的能力并应用 为了使未来的赠款解决印度不利环境暴露的威胁。