1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India

1/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-印度

• 批准号: 10643868
• 负责人: Dorairaj Prabhakaran
• 金额: $ 30.48万
• 依托单位: CENTRE FOR CHRONIC DISEASE CONTROL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643868
• 关键词: Acceleration; Address; Adolescence; Adolescent; Adult; Advisory Committees; Affect; Aging; Air Pollutants; Air Pollution; Anthropometry; Area; Birth; Blood Pressure; Carbon; Cardiovascular Diseases; Cardiovascular system; Child; Childhood; Chronic; Chronic Disease; Complex; Country; Cross-Sectional Studies; DNA Methylation; Data; Development; Diameter; Disease; Education; Elderly; Elements; Environmental Exposure; Environmental Health; Epigenetic Process; Future; Gender; Genomic Segment; Gestational Diabetes; Glucose; Grant; Growth; Health; Human Resources; Hypertension; Impaired cognition; Incidence; Income; India; Individual; Inequality; Infrastructure; Insulin; Intervention; Joints; Level of Evidence; Life; Life Cycle Stages; Link; Location; Long-Term Effects; Longevity; Low Birth Weight Infant; Measurement; Measures; Mediating; Mentors; Metabolism; Metals; Meteorology; Modeling; Modification; Monitor; Myocardial Infarction; Nerve Degeneration; Nitrogen Dioxide; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Ozone; Participant; Particulate Matter; Pattern; Physical Performance; Policies; Pollution; Population; Populations at Risk; Pre-Eclampsia; Predisposition; Pregnancy; Pregnancy Complications; Premature Birth; Public Health; Research; Research Support; Research Training; Resolution; Retrospective Studies; Risk; Role; Rural; Sampling; Scanning; Science; Scientist; Socioeconomic Status; Temperature; Testing; Time; Training; Vulnerable Populations; Work; adverse birth outcomes; age related; arterial stiffness; cognitive development; cohort; early childhood; epigenome; experience; extreme temperature; frailty; human old age (65+); improved; indexing; infancy; infrastructure development; land use; low and middle-income countries; machine learning prediction; methylation pattern; mortality; muscle strength; novel strategies; predictive modeling; programs; sex; socioeconomics; spatiotemporal; therapy design; urban setting

Project Summary Air pollution represents a major public health threat in India, affecting a quarter of the country’s population at extreme levels. The evidence on health impacts of air pollution, which mainly comes from high income countries, is not transferable to LMICs like India with complex urban environments and high pollution levels. The proposal entitled “1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India” builds on the research and infrastructure established in the ongoing (to be completed on 7/30/2021), Air pollution and Health GEOHealth Program. In the current proposal we aim to extend our exposure assessments to include a range of air pollutants: particulate matter with aerodynamic diameter <2.5m (PM2.5), nitrogen dioxide (NO2) and ozone (O3), and extremes of temperature to assess the exposomes at fine spatiotemporal resolutions across different locations in India (Delhi, Chennai, Sonipat, Vizag, Pune, Hyderabad and Bikaner). Additionally, we will evaluate the composition of PM2.5 in these locations and measure real time exposures in a subset of the participants. These exposomes will be related to a range of chronic non- communicable diseases across the life course using inter-digitating cohorts. This will be achieved by leveraging existing pregnancy, children, adult, and older adult cohorts across India. This will help us systematically assess the vulnerable populations across pregnancy, infancy, childhood, adolescence, adult and older adult groups. We will also address how environmental exposomes interact with gender, socio-economic status, rural-urban settings, and pre-existing illnesses in impacting the health outcomes. Further, we will replicate the findings from our epigenome-wide scan (from the ongoing study) in larger set of samples to validate DNA methylation profiles associated with incident myocardial infarction and explore if these epigenetic mechanisms mediate the effect of exposomes on myocardial infarction. Through this joint application, we will accelerate scientific infrastructure development, enhance research training to support research needed to characterize the relationship between environmental exposomes and health outcomes across the lifespan in India. The study will be led by Dr. Prabhakaran from CCDC and Dr. Reddy from PHFI and Dr. Schwartz and Dr. Sieber from HSPH, who will be assisted by the: 1) External Advisory Committee; 2) Administrative Oversight Committee; 3) Training Oversight Committee; 4) Program coordination personnel at HSPH and CCDC; and 5) Supervisory teams for individual trainees (Indian & HSPH mentors). The proposed study findings will identify the policy reforms needed to address the growing burden of air pollution and protect the large at-risk population. The training of the Indian scientists in the linked U2R in the area of environmental health will build capacity to undertake relevant studies and apply for future grants to address the threat from adverse environmental exposures in India.

项目概要 空气污染是印度主要的公共卫生威胁，影响了该国四分之一的人口 极端水平。关于空气污染对健康影响的证据主要来自高收入国家， 无法转移到像印度这样城市环境复杂、污染程度高的中低收入国家。提案 题为“1/2-GEOHealth 选定的环境暴露物对整个生命周期的健康影响” （治愈）-印度”建立在正在进行的研究和基础设施的基础上（将于 2021 年 7 月 30 日），空气污染与健康 GEOHealth 计划。在当前的提案中，我们的目标是扩大我们的曝光度 评估包括一系列空气污染物：空气动力学直径<2.5μm的颗粒物（PM2.5）， 二氧化氮 (NO2) 和臭氧 (O3) 以及极端温度来评估精细条件下的暴露组 印度不同地点（德里、钦奈、索尼帕特、维扎格、浦那、海得拉巴）的时空分辨率 和比卡内尔）。此外，我们还将评估这些地点的PM2.5成分并实时测量 一部分参与者的暴露。这些暴露组将与一系列慢性非 使用叉指队列来研究整个生命过程中的传染病。这将通过利用 印度各地现有的怀孕、儿童、成人和老年人群体。这将有助于我们系统地评估 怀孕、婴儿、儿童、青少年、成人和老年人群体中的弱势群体。我们 还将讨论环境暴露如何与性别、社会经济地位、城乡关系相互作用 环境和既存疾病对健康结果的影响。此外，我们将复制研究结果 我们对大量样本进行表观基因组扫描（来自正在进行的研究），以验证 DNA 甲基化谱 与心肌梗塞事件相关，并探讨这些表观遗传机制是否介导 暴露组对心肌梗塞的影响。通过这次联合应用，我们将加速科学基础设施建设 发展，加强研究培训，以支持描述之间关系所需的研究 印度整个生命周期的环境暴露和健康结果。该研究将由博士领导。 来自 CCDC 的 Prabhakaran 和来自 PHFI 的 Reddy 博士以及来自 HSPH 的 Schwartz 博士和 Sieber 博士，他们将 协助机构： 1) 外部咨询委员会； 2）行政监督委员会； 3）培训监督 委员会; 4）HSPH和CCDC的项目协调人员； 5) 个人监督小组 学员（印度和 HSPH 导师）。拟议的研究结果将确定解决这些问题所需的政策改革 日益严重的空气污染负担并保护大量高危人群。印度科学家的培训 在环境健康领域相关的 U2R 中，将建设开展相关研究和应用的能力 未来拨款以解决印度不利环境暴露的威胁。