1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India

1/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-印度

基本信息

项目摘要

Project Summary Air pollution represents a major public health threat in India, affecting a quarter of the country’s population at extreme levels. The evidence on health impacts of air pollution, which mainly comes from high income countries, is not transferable to LMICs like India with complex urban environments and high pollution levels. The proposal entitled “1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India” builds on the research and infrastructure established in the ongoing (to be completed on 7/30/2021), Air pollution and Health GEOHealth Program. In the current proposal we aim to extend our exposure assessments to include a range of air pollutants: particulate matter with aerodynamic diameter <2.5m (PM2.5), nitrogen dioxide (NO2) and ozone (O3), and extremes of temperature to assess the exposomes at fine spatiotemporal resolutions across different locations in India (Delhi, Chennai, Sonipat, Vizag, Pune, Hyderabad and Bikaner). Additionally, we will evaluate the composition of PM2.5 in these locations and measure real time exposures in a subset of the participants. These exposomes will be related to a range of chronic non- communicable diseases across the life course using inter-digitating cohorts. This will be achieved by leveraging existing pregnancy, children, adult, and older adult cohorts across India. This will help us systematically assess the vulnerable populations across pregnancy, infancy, childhood, adolescence, adult and older adult groups. We will also address how environmental exposomes interact with gender, socio-economic status, rural-urban settings, and pre-existing illnesses in impacting the health outcomes. Further, we will replicate the findings from our epigenome-wide scan (from the ongoing study) in larger set of samples to validate DNA methylation profiles associated with incident myocardial infarction and explore if these epigenetic mechanisms mediate the effect of exposomes on myocardial infarction. Through this joint application, we will accelerate scientific infrastructure development, enhance research training to support research needed to characterize the relationship between environmental exposomes and health outcomes across the lifespan in India. The study will be led by Dr. Prabhakaran from CCDC and Dr. Reddy from PHFI and Dr. Schwartz and Dr. Sieber from HSPH, who will be assisted by the: 1) External Advisory Committee; 2) Administrative Oversight Committee; 3) Training Oversight Committee; 4) Program coordination personnel at HSPH and CCDC; and 5) Supervisory teams for individual trainees (Indian & HSPH mentors). The proposed study findings will identify the policy reforms needed to address the growing burden of air pollution and protect the large at-risk population. The training of the Indian scientists in the linked U2R in the area of environmental health will build capacity to undertake relevant studies and apply for future grants to address the threat from adverse environmental exposures in India.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Dorairaj Prabhakaran其他文献

Dorairaj Prabhakaran的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Dorairaj Prabhakaran', 18)}}的其他基金

Cardiovascular Disease (CVD) Phenotyping Core
心血管疾病 (CVD) 表型核心
  • 批准号:
    10622452
  • 财政年份:
    2022
  • 资助金额:
    $ 32.57万
  • 项目类别:
1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India
1/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-印度
  • 批准号:
    10685795
  • 财政年份:
    2015
  • 资助金额:
    $ 32.57万
  • 项目类别:
2/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-US
2/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-美国
  • 批准号:
    10448038
  • 财政年份:
    2015
  • 资助金额:
    $ 32.57万
  • 项目类别:
2/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-US
2/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-美国
  • 批准号:
    10643953
  • 财政年份:
    2015
  • 资助金额:
    $ 32.57万
  • 项目类别:
1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India
1/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-印度
  • 批准号:
    10643868
  • 财政年份:
    2015
  • 资助金额:
    $ 32.57万
  • 项目类别:
Air Pollution and HealthGeoHealth Hub Research and Capacity Building
空气污染与健康地球健康中心研究和能力建设
  • 批准号:
    9762998
  • 财政年份:
    2015
  • 资助金额:
    $ 32.57万
  • 项目类别:
Plan for Cardiovascular Research Training in Advanced Biostatistics, Aging, and H
高级生物统计学、衰老和健康方面的心血管研究培训计划
  • 批准号:
    8336985
  • 财政年份:
    2012
  • 资助金额:
    $ 32.57万
  • 项目类别:
Plan for Cardiovascular Research Training in Advanced Biostatistics, Aging, and H
高级生物统计学、衰老和健康方面的心血管研究培训计划
  • 批准号:
    8515404
  • 财政年份:
    2012
  • 资助金额:
    $ 32.57万
  • 项目类别:
PHFI-Emory Partnership for Seamless, Thorough and Efficient Human Subjects Resear
PHFI-埃默里大学合作开展无缝、彻底和高效的人体受试者研究
  • 批准号:
    8051372
  • 财政年份:
    2010
  • 资助金额:
    $ 32.57万
  • 项目类别:
Global Health Activities in Developing Countries to Combat Non-Communicable Chron
发展中国家抗击非传染性慢性病的全球卫生活动
  • 批准号:
    7963172
  • 财政年份:
    2009
  • 资助金额:
    $ 32.57万
  • 项目类别:

相似海外基金

Identification of Prospective Predictors of Alcohol Initiation During Early Adolescence
青春期早期饮酒的前瞻性预测因素的鉴定
  • 批准号:
    10823917
  • 财政年份:
    2024
  • 资助金额:
    $ 32.57万
  • 项目类别:
Socio-Emotional Characteristics in Early Childhood and Offending Behaviour in Adolescence
幼儿期的社会情感特征和青春期的犯罪行为
  • 批准号:
    ES/Z502601/1
  • 财政年份:
    2024
  • 资助金额:
    $ 32.57万
  • 项目类别:
    Fellowship
Cognitive and non-cognitive abilities and career development during adolescence and adult development: from the perspective of genetic and environmental structure
青春期和成人发展期间的认知和非认知能力与职业发展:从遗传和环境结构的角度
  • 批准号:
    23K02900
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Reasoning about Spatial Relations and Distributions: Supporting STEM Learning in Early Adolescence
空间关系和分布的推理:支持青春期早期的 STEM 学习
  • 批准号:
    2300937
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
    Continuing Grant
Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors
青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响
  • 批准号:
    10785373
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan
绘制青春期和整个生命周期饮酒的神经生物学风险和后果
  • 批准号:
    10733406
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence
睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用
  • 批准号:
    10676403
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
Thalamo-prefrontal circuit maturation during adolescence
丘脑-前额叶回路在青春期成熟
  • 批准号:
    10585031
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
Interdisciplinary Perspectives on the Politics of Adolescence and Democracy
青少年政治与民主的跨学科视角
  • 批准号:
    EP/X026825/1
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
    Research Grant
An Empirical Study on the Influence of Socioeconomic Status in Adolescence on Exercise Habits in Adulthood
青春期社会经济地位对成年期运动习惯影响的实证研究
  • 批准号:
    23K16734
  • 财政年份:
    2023
  • 资助金额:
    $ 32.57万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了