Diversity-focused Montefiore Einstein Clinical Oncology Training Program in the Bronx

布朗克斯区注重多样性的蒙特菲奥里·爱因斯坦临床肿瘤学培训项目

• 批准号: 10646803
• 负责人: Yvonne Margaret Saenger
• 金额: $ 2.57万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646803
• 关键词: Albert Einstein Cancer Center; Basic Science; Biometry; Cancer Center; Catchment Area; Clinical Investigator; Clinical Oncology; Clinical Research; Clinical Trials; Community Outreach; Development; Discipline; Doctor of Medicine; Doctor of Philosophy; Ecosystem; Educational Curriculum; Educational workshop; Enrollment; Equity; Evaluation; Funding; Goals; Grant; Immunotherapy; Institution; Investigational Therapies; K-Series Research Career Programs; Leadership; Liquid substance; Malignant Neoplasms; Medicine; Mentored Clinical Scientist Development Program; Mentors; Minority; Minority Groups; Modeling; Oncology; Outcome; Participant; Population; Population Heterogeneity; Positioning Attribute; Principal Investigator; Publications; Qualifying; Research; Research Methodology; Research Personnel; Research Project Grants; Solid Neoplasm; Therapeutic; Therapeutic Research; Training; Training Programs; Translational Research; Wages; Writing; cancer care; cancer research center director; care delivery; career; community engagement; comparative effectiveness; design; medical schools; next generation; novel; patient oriented; programs; recruit; senior faculty; translational scientist; underserved minority

Project Abstract The goal of Einstein/Montefiore Paul Calabresi Career Development Award for Clinical Oncology and Equity Research is to train the next generation of oncology scholars, with a special emphasis on conducting clinical and translational research in the underserved and diverse Bronx catchment area. This will be achieved through a coordinated program of mentoring, a comprehensive formal curriculum, and research projects with an interdisciplinary, collaborative design with focus on community outreach and engagement. The program, its leadership and participants are integrated within the established research programs of the NCI-designated Montefiore Einstein Cancer Center (AECC). The Calabresi Program will select highly qualified clinical and translational investigators from all oncology disciplines, from a diverse group of primarily MDs, but also PhDs, who are committed to careers in patient-oriented clinical and translational research with a focus on diverse populations. The duration of the training is 2 to 3 years and funding for 4 scholars is requested. The research focus is being expanded beyond cancer therapeutics to include cancer care delivery relevant to the Bronx population, which is 70% URM’s. A formal curriculum has been developed in conjunction with Einstein’s Institute for Clinical and Translational Research (ICTR) featuring an MS degree in Clinical Research Methods and includes two mandatory Calabresi-centered courses, one on “Clinical Trial Development in the Era of Personalized Cancer Medicine and Immunotherapy”, and another on “Comparative Effectiveness Therapeutic Research”. Additional courses and workshops are offered in Biostatistics and Grant writing. The Principal Investigators are Dr. Amit Verma, M.D., Director of the Division of Hemato-Oncology, and Dr. Yvonne Saenger, MD, Director of the Immunotherapy program and Coleader of Experimental Therapeutics. Both PIs bring complementary expertise in both liquid and solid tumors and also a track-recordin basic/translational and clinical research, as well as in mentoring junior clinical investigators. An Executive Committee of senior faculty leaders provide oversight in the selection and ongoing evaluation of the progress of the Scholars and the impact of the program. An Internal Advisory Board (IAB) chaired by cancer center director, Dr. Edward Chu, and an External Advisory Board with K12 PIs will provide guidance and direction to the Calabresi program. Novel initiatives are planned to increase the recruitment of URM candidates. Strong institutional support from the Medical College, Cancer Center and Montefiorehas resultedin salary support of numerous scholars. Since inception, the Program has enrolled 24 Scholars (3 URMs): with 22 remaining committed to academic careers in leadership positions in oncology. A successful track record of high impact publications, especially in fields of minority outcomes in diverse populations of the Bronx is evidence of uniqueness of the proposed training program. Our proposed K12 training grant will train the next generation of oncology clinical researchers on unique challenges of conducting successful clinical trials in underserved minority populations, using the Bronx as a model ecosystem.

项目摘要 Einstein/Montefiore Paul Calabresi临床肿瘤学和公平职业发展奖的目标 研究是为了培养下一代肿瘤学学者，特别强调进行临床和 在服务不足和多样化的布朗克斯集水区进行转化研究。这将通过一个 协调的指导计划，全面的正式课程和研究项目， 跨学科的协作设计，重点是社区外展和参与。该计划，其 领导层和参与者被整合到NCI指定的既定研究计划中， Montefiore Einstein癌症中心（AECC）。Calabresi计划将选择高素质的临床和 来自所有肿瘤学学科的翻译研究者，来自不同的群体，主要是医学博士，也有博士， 谁致力于以患者为导向的临床和转化研究的职业生涯，重点是多样化的 人口。培训时间为2至3年，并要求为4名学者提供资金。研究 重点正在扩大到癌症治疗以外，包括与布朗克斯相关的癌症护理服务 人口，其中70%是URM的。与爱因斯坦研究所合作， 临床和转化研究（ICTR），具有临床研究方法硕士学位， 包括两个强制性的卡拉布里亚为中心的课程，一个是“临床试验的发展， 个性化癌症医学和免疫治疗”，另一个是“比较有效的治疗 研究”。在生物统计学和赠款写作提供额外的课程和讲习班。校长 研究人员是Amit Verma博士，医学博士，血液肿瘤科主任和Yvonne Saenger博士， 医学博士，免疫治疗项目主任和实验治疗学共同领导者。两个PI带来 在液体和实体肿瘤方面的互补专业知识，以及基础/翻译和临床跟踪记录 研究，以及指导初级临床研究人员。高级教师领导的执行委员会 提供监督的选择和正在进行的评估的进展学者和影响的 程序.由癌症中心主任Edward Chu博士担任主席的内部顾问委员会（IAB）和外部顾问委员会（IAB）。 K12 PI咨询委员会将为卡拉布雷西项目提供指导和方向。新举措是 计划增加对统一资源管理候选人的征聘。来自医学院的强大机构支持， 癌症中心和蒙蒂菲奥里已经导致了许多学者的工资支持。自成立以来，该方案 招收了24名学者（3个URM）：其中22名致力于在学术生涯中担任领导职务， 肿瘤学在高影响力出版物方面的成功记录，特别是在少数群体成果领域， 布朗克斯不同的人口是所提出的训练计划的独特性的证据。我们的建议K12 培训补助金将培训下一代肿瘤学临床研究人员进行独特的挑战， 以布朗克斯为生态系统模型，在服务不足的少数民族人群中进行成功的临床试验。