Post-Graduate Hematology/Oncology Translational (PG-HOT) Training Program

项目摘要(摘要) 这是一项资助新的研究生血液学/肿瘤学翻译(PG-HOT)培训的建议 辛辛那提大学内科血液科/肿瘤科 医学院。这款新T32的基本原理植根于最近加快的基础研究和 辛辛那提大学过去十年的临床癌症研究。从相对谦虚的开始 一开始，我们现在有足够多的有资金支持的研究人员和他们互补的毕业生 和研究生实习生，以证明NCI资源的投资将我们的癌症工作转移到下一个 水平。在这方面，我们仔细分析了我们的优势和劣势，并仔细研究了现有的 由NCI赞助的培训计划，并构建了我们的建议，以增强我们的优势 并填补了现有方案中的一定空白。火爆的PG培训计划将包括以下内容 参赛科系：内科、肿瘤生物学、儿科、药理学与系统 生理学。我们请求为3名博士后实习生(博士或博士/医学博士)和1名临床研究员(医学博士或医学博士)提供支持 医学博士学位)。PG-HOT的主要目标是培养一支受过独特培训的癌症研究人员队伍，以迅速 将新发现转化为癌症患者护理。最重要的理论基础与《登月记》相互配合 主动权。具体目标是：(1)就知识分子的作用提供正式和综合的指导 在以市场为基础的复杂经济背景下药品开发的财产保护 受政府监管。(2)提供全面的抗癌化合物教学和实践培训 评估，主要侧重于如何概念化、设计、管理和成功地进行严格培训 完成一项涉及新药的临床试验。(三)建立协同推进机制 博士科学家和MD-MD/博士临床医生之间真正有创意和富有成效的互动。我们的努力 将重点培养初级调查人员，使其在随后的学术界职业生涯中成为有效的合作者， 行业，或临床护理。这些目标将通过招聘高素质的申请者来实现，包括 少数族裔代表性不足，国内和国际知名科学家的指导，我们的支持 研究密集型部门和几个基础科学部门，资金充足的机构项目和 中心，以及来自内部和外部咨询委员会杰出而热心的成员的意见。

Project Summary (Abstract) This is a proposal to fund a new Post Graduate Hematology/Oncology Translational (PG-HOT) training program led by Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine. The rationale for this new T32 is rooted in the recent acceleration of basic research and clinical cancer investigation at University of Cincinnati over the past decade. Starting with relatively modest beginnings, we now have a sufficient critical mass of funded investigators and their complementary graduate and postgraduate trainees to justify the investment of NCI resources into moving our cancer effort to the next level. In that context, we have carefully analyzed our strengths and weaknesses, along with a perusal of existing training programs sponsored by the NCI, and have structured our proposal to both build on our strengths and fill a certain gap in the existing programs. The PG-HOT training program will have the following participating departments: Internal Medicine, Cancer Biology, Pediatrics, and Pharmacology and Systems Physiology. We request support for 3 postdoctoral trainees (PhD or PhD/MD) and 1 clinical fellow (MD or MD/PhD). PG-HOT’s main objective is to generate a cadre of cancer researchers uniquely trained to rapidly translate new discoveries into cancer patient care. The overarching rationale synergizes with the “Moonshot” initiative. The specific goals are: (1) To provide formal and integrated instruction on the role of intellectual property protection in drug development in the context of a complex economy that is both market-based and government-regulated. (2) To provide a comprehensive didactic and practical training in anti-cancer compound evaluation, with a primary focus on rigorous training in how to conceptualize, design, manage, and successfully carry to completion a clinical trial involving a novel drug. (3) To establish a collaborative structure that promotes genuinely creative and productive interactions between PhD scientists and MD-MD/PhD clinicians. Our effort will center on training junior investigators to be effective collaborators in their subsequent careers in academia, industry, or clinical care. These goals will be achieved by recruitment of high-quality applicants including underrepresented minorities, mentorship by nationally and internationally renowned scientists, support by our research-intensive Division and several basic-science departments, well-funded institutional programs and centers, and input from distinguished and enthusiastic members of Internal and External Advisory Boards.