Post-Graduate Hematology/Oncology Translational (PG-HOT) Training Program

项目摘要（摘要） 这是一项资助新的研究生血液学/肿瘤学转化（PG-HOT）培训的提案 由辛辛那提大学内科血液学/肿瘤学部门领导的项目 医学院。这种新型T32的基本原理植根于最近基础研究的加速， 辛辛那提大学的临床癌症研究。从相对温和的 开始，我们现在有足够的资助调查人员和他们的互补毕业生的临界质量 和研究生学员，以证明NCI资源的投资，将我们的癌症工作推向下一个 水平在这方面，我们仔细分析了我们的长处和短处，沿着研究了现有的 培训计划由NCI赞助，并已构建我们的建议，以建立我们的优势， 填补现有项目的一定空白。PG-HOT培训计划将包括以下内容 参与部门：内科、癌症生物学、儿科、药理学和系统 Physiology.我们请求支持3名博士后培训生（博士或博士/医学博士）和1名临床研究员（医学博士或 MD/PhD）。PG-HOT的主要目标是培养一批经过独特培训的癌症研究人员， 将新发现转化为癌症患者护理。总体原理与“登月计划”协同作用 倡议具体目标是：（1）提供关于知识分子作用的正式和综合指导 在以市场为基础， 政府监管。(2)提供抗癌化合物的综合教学和实践培训 评估，主要侧重于如何概念化，设计，管理和成功的严格培训 完成一种新药的临床试验。(3)建立一个合作结构，促进 博士科学家和MD-MD/PhD临床医生之间的真正创造性和富有成效的互动。我们的努力 将集中训练初级调查人员在他们随后的学术生涯中成为有效的合作者， 工业或临床护理。这些目标将通过招聘高素质的申请人来实现， 代表性不足的少数民族，国内和国际知名科学家的指导，我们的支持， 研究密集型部门和几个基础科学部门，资金充足的机构计划， 中心，并从内部和外部咨询委员会的杰出和热情的成员投入。

Project Summary (Abstract) This is a proposal to fund a new Post Graduate Hematology/Oncology Translational (PG-HOT) training program led by Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine. The rationale for this new T32 is rooted in the recent acceleration of basic research and clinical cancer investigation at University of Cincinnati over the past decade. Starting with relatively modest beginnings, we now have a sufficient critical mass of funded investigators and their complementary graduate and postgraduate trainees to justify the investment of NCI resources into moving our cancer effort to the next level. In that context, we have carefully analyzed our strengths and weaknesses, along with a perusal of existing training programs sponsored by the NCI, and have structured our proposal to both build on our strengths and fill a certain gap in the existing programs. The PG-HOT training program will have the following participating departments: Internal Medicine, Cancer Biology, Pediatrics, and Pharmacology and Systems Physiology. We request support for 3 postdoctoral trainees (PhD or PhD/MD) and 1 clinical fellow (MD or MD/PhD). PG-HOT’s main objective is to generate a cadre of cancer researchers uniquely trained to rapidly translate new discoveries into cancer patient care. The overarching rationale synergizes with the “Moonshot” initiative. The specific goals are: (1) To provide formal and integrated instruction on the role of intellectual property protection in drug development in the context of a complex economy that is both market-based and government-regulated. (2) To provide a comprehensive didactic and practical training in anti-cancer compound evaluation, with a primary focus on rigorous training in how to conceptualize, design, manage, and successfully carry to completion a clinical trial involving a novel drug. (3) To establish a collaborative structure that promotes genuinely creative and productive interactions between PhD scientists and MD-MD/PhD clinicians. Our effort will center on training junior investigators to be effective collaborators in their subsequent careers in academia, industry, or clinical care. These goals will be achieved by recruitment of high-quality applicants including underrepresented minorities, mentorship by nationally and internationally renowned scientists, support by our research-intensive Division and several basic-science departments, well-funded institutional programs and centers, and input from distinguished and enthusiastic members of Internal and External Advisory Boards.