Integrated Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10647896
• 负责人: ELAINE SYMANSKI
• 金额: $ 15.7万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647896
• 关键词: Agriculture; Area; Automobile Driving; Basic Science; Bioinformatics; Biological Markers; Biological Specimen Banks; Biometry; Chemicals; Clinic; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Computer Analysis; Consultations; Core Facility; Country; Data Analyses; Disasters; Disease; Education; Educational workshop; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Extramural Activities; Fees; Fishes; Fostering; Funding; Gases; Genetic; Goals; Grant; Health; Health Promotion; Health Sciences; Health Services; Home; Human; Hurricane; Individual; Industry; Institution; Intervention; Laboratories; Laboratory Research; Life; Medical; Medical center; Medicine; Modeling; National Institute of Environmental Health Sciences; Oils; Outcome; Parents; Participant; Pilot Projects; Plants; Population Heterogeneity; Population Sciences; Population Study; Predisposition; Public Health Schools; Publications; Research; Research Personnel; Resources; Sampling; Services; Structure; Surveys; Technology; Texas; Translating; Translational Research; Translations; Universities; Vision; Work; base; biobank; catalyst; college; community based research; community engagement; community partnership; design; ethnic diversity; experience; gulf coast; health science research; human population study; improved; innovation; instrumentation; inter-institutional; interest; man; member; population based; practical application; programs; protocol development; public health research; response; superfund site; symposium

ABSTRACT: INTEGRATED HEALTH SCIENCES FACILITY CORE The Houston-Galveston area is home to over a dozen Superfund sites, and a hub for the petrochemical industry with 500 chemical plants, 10 refineries and >6000 miles of oil, gas and chemical pipelines in what has become the country’s largest energy corridor. The area is also home to the largest medical center in the world, the Texas Medical Center. Thus, both the need and size of the opportunity, for an NIEHS Environmental Health Sciences (EHS) Core Center (EHS-CC) in this region is great. As the EHS-CC for the Texas Medical Center, the Gulf Coast Center for Precision Environmental Health (GC-CPEH) will be the focal point and catalyst for impactful EHS research, bi-directional communication with local communities and stakeholders, and the engine driving translation of precision environmental health research advances to improve human health. The Integrated Health Sciences Facility Core (IHSFC) was developed to provide Center members with support to conduct impactful translational environmental health sciences (EHS) research by leveraging unique resources and community partnerships across the three GC-CPEH parent institutions: Baylor College of Medicine (BCM), UTHealth School of Public Health (UTH-SPH), and University of Texas Medical Branch (UTMB). The guiding Vision for the IHSFC is to facilitate forward and reverse translation of members’ research to promote health and reduce susceptibility to environmentally-related adverse health outcomes. The primary Goal is to provide seamless access to expertise and capabilities for translation of GC-CPEH members’ research in the basic sciences into human population studies, and facilitate “reverse translation” of findings from human-population based and clinical studies into new hypothesis-driven laboratory research. To achieve this Goal, the IHSFC will use “Translational Navigators” to connect GC-CPEH Members to IHSFC expertise and services and promote translational environmental health research of the Thematic Focus Areas of the Center: Early Life Genetic and Epigenetic Environment (GE2) Interactions; Disaster Research Response (DR2); and Identification of Mechanisms of, and Interventions for, Human Environmental Disease (MIHED). IHSFC components include: 1) Population Sciences; 2) Clinical Sciences: 3) Exposure Assessment; 4) Biomarkers and 5) Community Engagement. These components are supported by diverse and unique resources across the GC-CPEH, including a Mobile Clinical Research Unit, Environmental Health Service Clinics, Biorepositories, a Biomedical Geospatial Modeling Analytics Facility and Analytical Laboratories for environmental and biomarker assessment.

摘要：综合健康科学设施核心 休斯顿-加尔维斯顿地区拥有十多个超级基金站点，也是石化行业的中心 拥有 500 家化工厂、10 家炼油厂和超过 6000 英里的石油、天然气和化学品管道 该国最大的能源走廊。该地区也是世界上最大的医疗中心德克萨斯州医疗中心的所在地 医疗中心。因此，NIEHS 环境健康科学的需求和机会的大小 （EHS）核心中心（EHS-CC）在这个地区很棒。作为德克萨斯医疗中心的 EHS-CC，Gulf 海岸精准环境健康中心 (GC-CPEH) 将成为有影响力的焦点和催化剂 EHS研究、与当地社区和利益相关者的双向沟通​​以及发动机驱动 将精准的环境健康研究进展转化为改善人类健康。综合 健康科学设施核心 (IHSFC) 的开发是为了向中心成员提供支持，以开展 通过利用独特的资源和影响力的转化环境健康科学（EHS）研究 三个 GC-CPEH 母机构之间的社区合作伙伴关系：贝勒医学院 (BCM)、 UTHealth 公共卫生学院 (UTH-SPH) 和德克萨斯大学医学分院 (UTMB)。指导性的 IHSFC 的愿景是促进会员研究的正向和反向转化，以促进健康和 降低对与环境相关的不良健康结果的敏感性。主要目标是提供 无缝获取专业知识和能力，以翻译 GC-CPEH 成员的基础研究 将科学融入人类研究，并促进人类研究结果的“反向翻译” 基于和临床研究的新假设驱动的实验室研究。为了实现这一目标，IHSFC 将 使用“翻译导航器”将 GC-CPEH 会员与 IHSFC 专业知识和服务联系起来， 促进中心主题重点领域的转化环境健康研究：早期生活 遗传和表观遗传环境（GE2）相互作用；灾害研究响应（DR2）；和鉴定 人类环境疾病（MIHED）的机制和干预措施。 IHSFC 组件包括： 1）人口科学； 2) 临床科学： 3) 暴露评估； 4) 生物标志物和 5) 社区 订婚。这些组件得到 GC-CPEH 多样化且独特的资源的支持， 包括移动临床研究中心、环境健康服务诊所、生物样本库、生物医学中心 用于环境和生物标志物评估的地理空间建​​模分析设施和分析实验室。