Translational Science Initiative

项目总结/摘要： 该应用程序的主要目标是改善和维护加勒比灵长类动物研究中心（CPRC）的 独特的研究资源，通过支持业务，管理，兽医护理和研究。的 CPRC由四个综合设施组成：（1）Cayo圣地亚哥野外站，CPRC中最有价值的 拥有一群自由放养的恒河猴的研究资源，这些恒河猴是1938年从印度带到圣地亚哥岛的。 (2)萨瓦纳塞卡野外站，CPRC的总部位于圣胡安外10英里处， 恒河猴来自Cayo圣地亚哥殖民地，在各种户外配置，用于生物医学和 在自由放养的动物上不可行的行为研究;（3）病毒学和遗传学实验室 (LVG)位于圣胡安的医学科学校园（MSC），支持多项研究计划 以恒河猴为模型;以及（4）灵长类动物形态学实验室，该实验室也位于 在MSC，并容纳CPRC骨骼收藏，非人类灵长类动物骨骼的独特组合， 遗传、发育、病理和解剖学研究。如本提案所述，CPRC的组织结构如下： 分为四个互补和综合部门：灵长类动物资源，病毒学和遗传学，行为和 神经科学和灵长类动物形态学。本申请要求提供资金， 灵长类动物资源的基础设施，用于支持当地，国家和 化国际大这笔赠款还将使CPRC继续支持转化科学倡议（TSI） 应用研究部分。该TSI的一个主要优势是进行多学科 合作研究，为临床前转化项目建立和验证NHP模型， 不同的人类疾病在NIH的持续支持下，CPRC仍将是一项重要的国家研究。 资源，并将能够提供健康的印度原产恒河猴的定义的遗传和病毒学 NIH赞助的研究项目的背景。

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Santiago Field Station, the most valuable of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago (CS) in 1938.; (2) the Sabana Seca Field Station, the CPRC's head quarters located 10 miles outside of San Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology. Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects locally, national and internationally. This grant will also allow CPRC to continue supporting the Translational Science Initiative (TSI) under the Applied Research Component. A major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP models for preclinical translational projects related to different human diseases. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.