Local Neuronal Drive and Neuromodulatory Control of Activity in the Pial Neurovascular Circuit

软脑膜神经血管回路活动的局部神经元驱动和神经调节控制

• 批准号: 10649627
• 负责人: Anna Devor
• 金额: $ 278.44万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-16 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649627
• 关键词: Adopted; Affect; Analog Computers; Area; Behavioral; Blood; Blood capillaries; Blood flow; Brain; Brain region; Cell Nucleus; Collaborations; Computing Methodologies; Coupled; Coupling; Data; Data Analyses; Data Collection; Dedications; Detection; Diameter; Education; Electroencephalography; Electrophysiology (science); Elements; Endothelium; Esthesia; Frequencies; Functional Magnetic Resonance Imaging; Generations; Homeostasis; Human; Image; Individual; Joints; Knowledge; Lead; Location; Locomotion; Logic; Magnetic Resonance Imaging; Mathematics; Measurement; Measures; Mechanics; Mediating; Microscopy; Modality; Modeling; Mus; Nature; Neuromodulator; Neurons; Neurosciences; Optics; Output; Oxygen; Pattern; Periodicity; Phase; Physiology; Process; Publications; Recording of previous events; Regulation; Resolution; Rest; Science; Signal Transduction; Smooth Muscle; Spinal; Structure; Technology; Testing; Theoretical Studies; Training; Vascular Endothelium; Vascular blood supply; Vasomotor; Vertebral column; analytical method; arteriole; awake; central pattern generator; constriction; data acquisition; experimental study; fascinate; graduate school; hemodynamics; human subject; in vivo; interest; network models; neural; neuroregulation; neurovascular; neurovascular coupling; optical imaging; oxygen transport; spatiotemporal; theories; two-dimensional; vasomotion

PROJECT SUMMARY/ABSTRACT – OVERALL We seek to understand the nature of the pial neurovascular circuit, whose dynamics is characterized by ultralow frequency oscillations near 0.1 Hz that parcellate into separate coherent regions across cortex. We will use this knowledge to form a mathematical relation between the hemodynamic patterns observed in optical and functional magnetic resonance imaging experiments and the underlying brain state. Our proposed studies propose to leverage our experimental expertise in in vivo optical microscopy in mouse and fMRI in mouse and human. These primary modalities for data acquisition are combined with behavioral training, electrophysiology, and data analysis. Our experimental effort is parallel by two theoretical efforts. One mixed analytical/computational effort is on coupled oscillator dynamics to formulate models, at varying levels of complexity, of the pial neurovascular circuit. A second solely computational effort concerns the modulation of the transport of oxygen, by regional oscillations of the pial neurovascular circuit. The pial neurovascular circuit is composed of a two-dimensional network of pial arterioles that undergo rhythmic oscillations in the ~ 0.1 Hz vasomotor band. Each element in this circuit - a segment of arteriole whose diameter is modulated by the constriction/dilation of smooth muscle, contains an intrinsic rhythm generator, much like intrinsic bursting neurons in central pattern generators. The pial arterioles integrate neuronal activity from neighboring arterioles, underlying neurons, subcortical neurons, and neuromodulatory centers to produce dynamic patterns of coherent oscillations in arteriolar diameter across the cortical mantle. These patterns contain regions that oscillate at slightly different frequencies, i.e., they parcellate into separate regions. The fascinating issue is that the parcellation only partially reflects input from the directly underlying neuronal input. We seek to understand, model, and exploit this parcellation. The PIs have collaborated on issues in neuroscience and neurovascular science for many years. This proposal is a result of their discoveries and converging interest in a structured collaborative effort. Project 1 will formulate an understanding of fundamental physiology of the pial neurovascular circuit. This includes determining if brain arterioles truly act as interacting non-linear oscillators, i.e., that they entrain and phase-lock rather than passively filter. Projects 1, 2, and 4 will explore experimentally and theoretically how four competitive interactions, viz, input from neighboring arterioles, (ii) input from underlying neurons, (iii) input from subcortical areas involved in homeostasis; and (iv) input from brain neuromodulatory centers, lead to the observed patterns of pial neurovascular activity. Projects 2 and 4 will explore and model the regulation of oxygen in subsurface vessels, while Project 3 will expand the resolution of MR imaging in humans to observe single vessels CBV changes and thus measure pial neurovascular dynamics with unparalleled resolution. A particular interest is to transform spatiotemporal patterns of vasomotion into predictions of internal brain state.

项目摘要/摘要-总体

项目成果

High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex.

高分辨率定量和功能性MRI表明人类次级视觉皮层中薄和厚条纹的髓鞘降低。

• DOI: 10.7554/elife.78756
• 发表时间: 2023-03-08
• 期刊: eLife
• 影响因子: 7.7
• 作者: Haenelt D;Trampel R;Nasr S;Polimeni JR;Tootell RBH;Sereno MI;Pine KJ;Edwards LJ;Helbling S;Weiskopf N
• 通讯作者: Weiskopf N

A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI.

• DOI: 10.1177/0271678x211037266
• 发表时间: 2021-11
• 期刊: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
• 作者: Raimondo L;Knapen T;Oliveira ĹAF;Yu X;Dumoulin SO;van der Zwaag W;Siero JCW
• 通讯作者: Siero JCW

MESH-FREE HIGH-RESOLUTION SIMULATION OF CEREBROCORTICAL OXYGEN SUPPLY WITH FAST FOURIER PRECONDITIONING.

通过快速傅立叶预处理对脑皮质供氧进行无网格高分辨率模拟。

• DOI: 10.1101/2023.01.09.523320
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Ventimiglia,Thomas;Linninger,AndreasA
• 通讯作者: Linninger,AndreasA

Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice

局灶性皮质下白质病变破坏小鼠静息状态皮质半球间功能连接

• DOI: 10.1093/cercor/bhab134
• 发表时间: 2021
• 期刊: Cerebral Cortex
• 影响因子: 3.7
• 作者: Aykan Sanem A;Xie Hongyu;Lai James Han;Zheng Yi;Chung David Y;Kura Sreekanth;Anzabi Maryam;Sugimoto Kazutaka;McAllister Lauren M;Yaseen M Abbas;Boas David A;Whalen Michael J;Sakadzic Sava;Ayata Cenk
• 通讯作者: Ayata Cenk

Impact of stalling events on microcirculatory hemodynamics in the aged brain.

失速事件对老年大脑微循环血流动力学的影响。

• DOI: 10.1111/micc.12845
• 发表时间: 2024
• 期刊: Microcirculation (New York, N.Y. : 1994)
• 作者: Jamshidi,Mohammad;Ventimiglia,Thomas;Sudres,Patrice;Zhang,Cong;Lesage,Frédéric;Rooney,William;Schwartz,Daniel;Linninger,AndreasA
• 通讯作者: Linninger,AndreasA