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FAIR DOs: Findable, Accessible, Interoperable, Reusable Development of Open Simulation

FAIR DOs: Findable, Accessible, Interoperable, Reusable Development of Open Simulation
FAIR DO:可查找、可访问、可互操作、可重用的开放模拟开发
批准号:
10523857
负责人:
Walter F Boron
金额:
$13.04万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-09-20 至 2027-06-30

项目摘要

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中文摘要
翻译
项目摘要 FAIR DO(Findable,Interoperable,Interoperable,Reusable:Development Of Simulations)是一个为期5年的研究项目。 消化和肾神经生物学建模和仿真的教育计划。它是由一个团队 获奖教师的教育工作者和研究人员谁,除其他外,是背后的公平地图 和知识管理基础设施。FAIR DOs的主旨是教育 下一代研究人员和临床医生在消化和肾上皮细胞的神经调节, 教学模块和有监督的建模项目,利用可重构数据集,地图和模型。的 FAIR DO的教师将利用凯斯西储大学的教学结构来招收学生。 整体而言,公平教育发展主任的目的是在拟议的五年内为超过75名学生提供约35/45小时的培训 项目,每个学生的研究项目在生理学杂志上发表一篇文章-由 国际生理科学联合会。该门户网站将为这些学生提供可查找性- 通过其搜索和平面地图功能生成开放获取模型和相关数据, 通过O2 S2 PARC仿真平台进行交互。总的来说,FAIR DOs的努力将提供一个独特的 具有教育意义和指导性的经验,还将产生一个由互操作模型组成的可扩展生态系统, 连贯地研究消化和肾上皮运输的神经生物学。从一个说教的“系统” 从这个角度来看,这个模型的生态系统将按照英国医学教育的教学叙述进行组织。 协会获奖“医学生理学第三版”。教科书,补充了最近的文献,设置 这是今后进一步利用可持续发展资源促进教育的阶段。
英文摘要
PROJECT SUMMARY FAIR DOs (Findable, Accessible, Interoperable, Reusable: Development Of Simulations) is a 5-year research education program in the modeling and simulation of digestive and renal neurobiology. It is developed by a team of award-winning faculty of educators and researchers who, among other things, is behind the FAIR mapping and knowledge management infrastructure for the SPARC effort. The main thrust of FAIR DOs is to educate the next generation of researchers and clinicians in the neural regulation of digestive and renal epithelia through taught modules and supervised modeling projects that make use of SPARC datasets, maps, and models. The FAIR DOs faculty will leverage teaching structures at Case Western Reserve University to recruit students. Overall, FAIR DOs aims to provide about 35/45 hours of training to over 75 students over the proposed five-year project, with each student research project producing one publication in the Physiome journal--launched by the International Union of Physiological Sciences. The SPARC Portal will provide findability to these student- generated open-access models and associated data via its Search and Flatmaps functions, as well as accessible interactivity via the O2S2PARC simulation platform. Overall, the FAIR DOs effort will provide a unique educational, mentored experience that will also generate a SPARC ecosystem of interoperating models that coherently study the neurobiology of digestive and renal epithelial transport. From a didactic “Systems” perspective, this ecosystem of models will be organized to follow the teaching narrative of the British Medical Association Award-winning “Medical Physiology 3rd Ed.” textbook, supplemented with recent literature, setting the stage to further leverage SPARC resources for education in the future.
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会议论文
Mechanisms of oxygen off-loading from red blood cells in murine models of human disease
  • 批准号:
    10343967
  • 项目类别:
  • 资助金额:
    $66.46万
  • 财政年份:
    2022
  • 负责人:
    Walter F Boron
  • 依托单位:
FAIR DOs: Findable, Accessible, Interoperable, Reusable Development of Open Simulation
Mechanisms of oxygen off-loading from red blood cells in murine models of human disease
  • 批准号:
    10548180
  • 项目类别:
  • 资助金额:
    $65.85万
  • 财政年份:
    2022
  • 负责人:
    Walter F Boron
  • 依托单位:
Molecular mechanism of Na+ -coupled HCO3- transporters: transport of CO3= and CO2
  • 批准号:
    10187218
  • 项目类别:
  • 资助金额:
    $69.76万
  • 财政年份:
    2021
  • 负责人:
    Walter F Boron
  • 依托单位:
海外基金