Vaping in Childhood and Adolescence: Cognitive and Behavioral Consequences

儿童和青少年时期吸电子烟：认知和行为后果

• 批准号: 10522539
• 负责人: Neal Doran
• 金额: $ 27.65万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10522539
• 关键词: Abstinence; Address; Adolescence; Adolescent; Affective; Age; Animals; Behavioral; Brain; Cardiovascular Diseases; Cells; Cessation of life; Characteristics; Charge; Child; Childhood; Chronic; Cigarette; Cigarette Smoker; Clinical; Cognitive; Cognitive deficits; Communities; Conflict (Psychology); Consumption; Crime; DNA; Data Set; Dependence; Development; Devices; Disease; Electronic cigarette; Expectancy; Exposure to; Family; Formulation; Friends; Goals; Health; High Prevalence; Home; Human; Individual; Inhalation; Intervention; JUUL; Knowledge; Lead; Life; Longitudinal cohort study; Lung diseases; Metabolic Diseases; Morbidity - disease rate; Morphology; Nature; Neurocognitive; Neurocognitive Deficit; Nicotine; Nicotine Dependence; Outcome; Pattern; Physiological; Policies; Population; Predictive Factor; Predisposition; Prevalence; Prevention; Prevention program; Psychological reinforcement; Research; Risk; Risk Factors; Self Efficacy; Sodium Chloride; System; Testing; Time; Tobacco; Tobacco Dependence; Tobacco use; Work; Youth; airway inflammation; authority; base; cigarette smoking; cohort; combustible tobacco; design; e-cigarette aerosols; effective intervention; electronic cigarette use; emotion regulation; gut inflammation; high school; interest; intervention program; junior high school; knowledge base; modifiable risk; mortality; neighborhood safety; neurobehavioral; nicotine exposure; parental monitoring; peer; peer influence; programs; prospective; prospective test; psychologic; reduce tobacco use; relating to nervous system; repaired; social; social media; therapy development; tobacco products; uptake; vaping

Project Summary/Abstract The long-term goal of this research program is to identify negative consequences associated with e-cigarettes and other newer tobacco products, and reduce the health burden of tobacco use by developing interventions and identifying policies to reduce youth use. This proposal focuses on e-cigarette use, which has increased substantially and is now the most common nicotine product used by US youth. Our collective knowledge is not yet sufficient to identify factors that can be targeted in e-cigarette interventions, or to be sure that we understand the negative consequences of use. We propose to take advantage of the unique nature of the ABCD study, which includes regular assessments of a large, nationally representative cohort from ages 9 to 19. The design of the study will allow us to examine a range of both (1) modifiable risk factors for e-cigarette use and (2) behavioral, psychological, neurocognitive, and physiological consequences of use. The goals of this study are to prospectively test the following hypotheses: (1) e-cigarette initiation and progression in children is driven by modifiable social, contextual, and individual risk factors; (2) children who try e-cigarettes will be more likely to become users of combustible tobacco products; (3) youth e-cigarette use is associated with neural alterations and neurocognitive deficits; (4) e-cigarette use in adolescence is associated with negative health consequences. Our goals are twofold. First, we seek to identify modifiable factors among children that are associated with risk of chronic tobacco use and dependence, in order to inform intervention development. Second, we aim to delineate the extent to which e-cigarette use causes negative physical, behavioral and cognitive consequences, in order to inform policymakers who have regulatory authority over tobacco products. The overarching goal is to reduce tobacco use among youth and thus associated morbidity and mortality.

项目摘要/摘要 该研究计划的长期目标是确定与电子烟有关的负面后果 和其他较新的烟草产品，并通过开发干预措施来减轻烟草使用的健康负担 并确定减少青年使用的政策。该提案重点介绍了电子烟的使用，这已经增加了 基本上是美国青年使用的最常见的尼古丁产品。我们的集体知识不是 然而足以确定可以针对电子烟干预措施的因素，或者确保我们 了解使用的负面后果。我们建议利用 ABCD研究，其中包括对9至9岁的全国代表人群的定期评估 19。研究的设计将使我们能够检查一系列（1）E烟的可修改风险因素 使用和（2）使用的行为，心理，神经认知和生理后果。 这项研究的目标是前瞻性检验以下假设：（1）电子烟开始和 儿童的进展是由可修改的社会，上下文和个人风险因素驱动的。 （2）尝试的孩子 电子烟将更有可能成为可燃烟草产品的使用者； （3）青年电子烟的使用是 与神经改变和神经认知缺陷有关； （4）在青春期中使用电子烟 负面的健康后果。 我们的目标是双重的。首先，我们试图确定与风险相关的儿童的可修改因素 慢性烟草使用和依赖性，以便为干预开发提供信息。第二，我们的目标是 描述电子烟的使用导致负面的身体，行为和认知的程度 后果是为了告知对烟草产品具有监管授权的政策制定者。这 总体目标是减少青少年使用烟草的使用，从而减少发病率和死亡率。