Vaping in Childhood and Adolescence: Cognitive and Behavioral Consequences

项目总结/摘要 这项研究计划的长期目标是确定与电子烟相关的负面后果 和其他新型烟草产品，并通过制定干预措施减少烟草使用的健康负担 并确定减少青少年使用的政策。这项提案的重点是电子烟的使用， 尼古丁是美国年轻人最常用的尼古丁产品。我们的集体知识 但足以确定电子烟干预措施中可以针对的因素，或者可以肯定， 了解使用的负面后果。我们建议利用 ABCD研究，包括对一个大型的、具有全国代表性的9岁至10岁的队列进行定期评估。 19.这项研究的设计将使我们能够检查一系列（1）电子烟的可改变风险因素 使用和（2）使用的行为、心理、神经认知和生理后果。 本研究的目的是前瞻性地检验以下假设：（1）电子烟的开始和 儿童的进展是由可改变的社会，背景和个人风险因素驱动的;（2）尝试 电子烟将更有可能成为可燃烟草产品的使用者;（3）青少年使用电子烟是 与神经改变和神经认知缺陷相关;（4）青少年使用电子烟与 对健康有负面影响。 我们的目标是双重的。首先，我们寻求确定与风险相关的儿童中的可改变因素 慢性烟草使用和依赖的研究，以便为干预措施的制定提供信息。第二，我们的目标是 描述电子烟使用对身体、行为和认知造成负面影响的程度 烟草制品的影响，以便向对烟草制品拥有监管权的决策者提供信息。的 总体目标是减少青年人吸烟，从而减少相关的发病率和死亡率。

Project Summary/Abstract The long-term goal of this research program is to identify negative consequences associated with e-cigarettes and other newer tobacco products, and reduce the health burden of tobacco use by developing interventions and identifying policies to reduce youth use. This proposal focuses on e-cigarette use, which has increased substantially and is now the most common nicotine product used by US youth. Our collective knowledge is not yet sufficient to identify factors that can be targeted in e-cigarette interventions, or to be sure that we understand the negative consequences of use. We propose to take advantage of the unique nature of the ABCD study, which includes regular assessments of a large, nationally representative cohort from ages 9 to 19. The design of the study will allow us to examine a range of both (1) modifiable risk factors for e-cigarette use and (2) behavioral, psychological, neurocognitive, and physiological consequences of use. The goals of this study are to prospectively test the following hypotheses: (1) e-cigarette initiation and progression in children is driven by modifiable social, contextual, and individual risk factors; (2) children who try e-cigarettes will be more likely to become users of combustible tobacco products; (3) youth e-cigarette use is associated with neural alterations and neurocognitive deficits; (4) e-cigarette use in adolescence is associated with negative health consequences. Our goals are twofold. First, we seek to identify modifiable factors among children that are associated with risk of chronic tobacco use and dependence, in order to inform intervention development. Second, we aim to delineate the extent to which e-cigarette use causes negative physical, behavioral and cognitive consequences, in order to inform policymakers who have regulatory authority over tobacco products. The overarching goal is to reduce tobacco use among youth and thus associated morbidity and mortality.