Vaping in Childhood and Adolescence: Cognitive and Behavioral Consequences

项目摘要/摘要 这项研究计划的长期目标是确定与电子烟相关的负面后果 和其他较新的烟草产品，并通过制定干预措施减少烟草使用的健康负担 以及确定减少青年使用的政策。这项提案的重点是电子烟的使用，电子烟的使用增加了 基本上，现在是美国年轻人使用的最常见的尼古丁产品。我们的集体知识不是 但仍足以确定电子烟干预措施中可以针对的因素，或确保我们 理解使用的负面后果。我们建议利用 JOU研究，包括对从9岁到9岁的具有全国代表性的大型队列的定期评估 19.这项研究的设计将使我们能够检查一系列(1)电子烟的可修改风险因素 使用和(2)使用的行为、心理、神经认知和生理后果。 这项研究的目标是前瞻性地检验以下假设：(1)电子烟的启动和 儿童的进展是由可改变的社会、背景和个人风险因素驱动的；(2)尝试 电子烟将更有可能成为可燃烟草产品的使用者；(3)青少年使用电子烟的情况 与神经改变和神经认知缺陷有关；(4)青春期使用电子烟与 会对健康造成负面影响。 我们的目标是双重的。首先，我们试图确定儿童中与风险相关的可改变因素。 关于长期烟草使用和依赖的信息，以便为干预发展提供信息。第二，我们的目标是 描述使用电子烟对身体、行为和认知造成负面影响的程度 为了让对烟草产品有监管权的政策制定者了解烟草产品的后果。这个 总体目标是减少青年中的烟草使用，从而减少相关的发病率和死亡率。

Project Summary/Abstract The long-term goal of this research program is to identify negative consequences associated with e-cigarettes and other newer tobacco products, and reduce the health burden of tobacco use by developing interventions and identifying policies to reduce youth use. This proposal focuses on e-cigarette use, which has increased substantially and is now the most common nicotine product used by US youth. Our collective knowledge is not yet sufficient to identify factors that can be targeted in e-cigarette interventions, or to be sure that we understand the negative consequences of use. We propose to take advantage of the unique nature of the ABCD study, which includes regular assessments of a large, nationally representative cohort from ages 9 to 19. The design of the study will allow us to examine a range of both (1) modifiable risk factors for e-cigarette use and (2) behavioral, psychological, neurocognitive, and physiological consequences of use. The goals of this study are to prospectively test the following hypotheses: (1) e-cigarette initiation and progression in children is driven by modifiable social, contextual, and individual risk factors; (2) children who try e-cigarettes will be more likely to become users of combustible tobacco products; (3) youth e-cigarette use is associated with neural alterations and neurocognitive deficits; (4) e-cigarette use in adolescence is associated with negative health consequences. Our goals are twofold. First, we seek to identify modifiable factors among children that are associated with risk of chronic tobacco use and dependence, in order to inform intervention development. Second, we aim to delineate the extent to which e-cigarette use causes negative physical, behavioral and cognitive consequences, in order to inform policymakers who have regulatory authority over tobacco products. The overarching goal is to reduce tobacco use among youth and thus associated morbidity and mortality.