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Remapping the Visual Field to Aid Reading with Central Scotomas

使用中央盲点重新映射视野以帮助阅读

基本信息

批准号：
10661846
负责人：
STEPHEN A. ENGEL
金额：
$ 37.24万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-06-30
项目状态：
未结题

项目摘要

Project Summary Age-related macular degeneration (AMD) typically produces extensive central vision loss, leading to difficulty in reading, navigating, and other critical tasks. Current assistive devices for vision with central scotomas, while promising, are limited in effectiveness. This proposal aims to fill this gap by advancing understanding of remapping, a method that improves the effectiveness of patients’ residual vision by shifting information from inside the central blind spot (scotoma) to intact locations in the visual field. Only a handful of past studies have examined remapping, including just a single study of patients. Our group recently demonstrated the method’s promise, showing that it can improve reading substantially in observers with simulated field loss. Critically, patients differ widely in the shape of their scotomas, and the quality of their vision across the visual field. This variability imposes severe limitations on the “one size fits all” remapping approaches used in prior work, that simply shift the image away from the scotoma center. If, for example, a patient’s preferred retinal location (used for high acuity tasks) is near the lower left edge of their scotoma, shifting text upward or rightward may not aid reading as much as shifting it downward, as the latter will place the text in regions of best visual acuity. This proposal will test the value of personalized remappings, which shift the image in a way that is optimized for each patient’s residual vision. The remappings are constructed using a novel letter recognition perimetry task, which measures performance across the visual field: The personalized remappings are constructed to shift text to maximize observers’ total letter recognition ability. Proposed work will first test the hypothesis that personalized remapping can improve single word recognition. Single word reading will be measured with a variety of scotoma sizes, shapes, and PRL locations. Performance with personalized remapping will be compared to that with traditional remapping and no remapping in both control observers with simulated scotomas and people with macular degeneration. Proposed work will also test the hypothesis that personalized remappings can improve free reading. Reading speed, error rates, and eye movement patterns will be measured in a sentence reading task, and in free reading of natural images containing text. Preliminary data support the value of remapping generally, and the potential of the letter recognition perimetry task for building personalized remappings. Results of this proposal will provide the first thorough testing of remapping, and will also inform models of peripheral reading in patients and controls. The proposed studies will develop and evaluate a novel method for assisting people with low-visions, tailored to their individual residual performance. Personlaized remapping may also be incorporated into practical visual aids to improve daily visual function and quality of life.

项目摘要视网膜相关性黄斑变性（AMD）通常产生广泛的中心视力丧失，导致难以治疗。阅读、导航和其他关键任务。目前针对中央暗点的视觉辅助设备，而有前途，但效果有限。该提案旨在通过增进对以下问题的理解来填补这一空白：重新映射，一种通过将信息从从中心盲点（暗点）到视野中的完整位置。只有少数过去的研究检查了重新映射，包括对患者的单一研究。我们的团队最近展示了该方法的承诺，表明它可以改善阅读与模拟场损失的观察员大幅。重要的是，患者的暗点形状和视野中的视觉质量差异很大。这可变性对先前工作中使用的“一刀切”重映射方法施加了严重的限制，简单地将图像从暗点中心移开。例如，如果患者的首选视网膜位置 (used对于高敏锐度任务）靠近他们的暗点的左下边缘，向上或向下移动文本可以向下移动并不能帮助阅读，因为后者会将文本置于最佳视觉敏锐度的区域。这个提议将测试个性化重新映射的价值，它以一种优化的方式移动图像每个病人的残余视力使用一种新的字母识别视野重建任务，它测量整个视野的表现：个性化的重新映射被构建为移动文本以最大化观察者的总字母识别能力。拟议的工作将首先测试假设，个性化重映射可以提高单个单词识别。单个单词阅读将使用暗点大小、形状和PRL位置的多样性。个性化重新映射的性能将与传统重映射和无重映射的控制观测器相比，暗点和黄斑变性患者。拟议的工作还将测试个性化的假设，重映射可以改善自由阅读。阅读速度、错误率和眼球运动模式将被在句子阅读任务中以及在自由阅读包含文本的自然图像中测量。初步数据一般支持重新映射的价值，以及字母识别视野检查任务用于构建个性化的重新映射。该提案的结果将提供重新映射的第一次彻底测试，并将还告知患者和对照组的外周阅读模型。拟议的研究将发展和评估一种新的方法，以帮助低视力的人，适合他们的个人剩余性能。个性化的重新映射也可以被结合到实际的视觉辅助中，以改善日常视觉功能，生活质量