Synaptic mechanisms of auditory thalamic cross-modal communication
听觉丘脑跨模式通讯的突触机制
基本信息
- 批准号:10540232
- 负责人:
- 金额:$ 32.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAnatomyAreaAttentionAuditoryAuditory areaAuditory systemBindingBrainCell NucleusCellsCharacteristicsChemical SynapseCommunicationCommunication impairmentDataDiseaseDorsalDyslexiaElectrical SynapseElectrophysiology (science)EnvironmentFailureGeneticGoalsHearingHeartImageIn VitroLasersLinkMapsMeasuresMedialMedial geniculate bodyMediatingModalityModelingModernizationMusNeuronsOpticsPathway interactionsPhysiologicalPopulationPreparationProcessPropertyRabiesResourcesRoleScanningSensorySignal TransductionSliceStimulusStreamStructureSynapsesSystemTestingThalamic NucleiThalamic structureThinnessTravelVirusVisualWorkauditory thalamusautism spectrum disorderawakecalcium indicatorcognitive changecomputer studiesgenetic manipulationimaging approachin vivoinducible Crelens cortexmultimodalitymultisensorynetwork architecturenoveloptical imagingpharmacologicresponsesegregationsensory processing disordersensory stimulussensory systemsomatosensory
项目摘要
ABSTRACT
Healthy subjects rapidly shift their attention in response to a dynamic sensory environment and
changing cognitive demands. Failure to quickly shift perceptual resources between auditory and
other modalities has been hypothesized to be a core deficit in both dyslexia and autism. Precisely
how the brain shuttles information between sensory systems is not known, but recent work
suggests that the thalamus contains circuits that have the capacity to rapidly transition between
different sensory modalities. Specifically, the thalamic reticular nucleus (TRN), a thin shell of
GABAergic neurons surrounding the thalamus, may serve as a link to allow communication
between different areas of the sensory thalamus, a phenomenon we refer to as thalamic “cross-
talk.” Based on recent data and our preliminary findings, we hypothesize that thalamo-TRN-
thalamic circuits provide critical connections between thalamic nuclei and therefore permit rapid
switching between auditory and other thalamocortical pathways. We propose to test this
hypothesis using a novel combination of anatomical, chemogenetic, optical stimulation and optical
imaging approaches in the mouse, using both slice and in vivo approaches. Specifically, we will
determine which of multiple potential circuit pathways is/are used to permit auditory, visual and
auditory thalamic nuclei to communicate with each other. Next, we will determine whether and
how such thalamic cross-talk influences synaptic responses at the level of the auditory cortex.
Finally, the impact of the TRN on cross-modal processing will be directly examined by optically
modulating the TRN while imaging cortical responses to combined sensory stimulation in awake
mice. Successful completion of this project will provide the first circuit-level characterization of the
role of the TRN in communication between the auditory thalamus and other thalamic regions. In
addition, this work will lay the groundwork for a greater understanding of how thalamoreticular
systems break down in disorders of communication.
摘要
健康受试者迅速转移他们的注意力,以响应动态的感觉环境,
改变认知需求。无法快速在听觉和听觉之间转换感知资源,
其他形式被假设为是诵读困难和自闭症的核心缺陷。精确
大脑如何在感觉系统之间穿梭信息尚不清楚,但最近的工作
表明丘脑含有能够快速转换的回路,
不同的感官形态具体来说,丘脑网状核(TRN),一个薄壳,
丘脑周围的GABA能神经元,可能作为一个链接,使通信
在感觉丘脑的不同区域之间,我们称之为丘脑“交叉-
说吧。”根据最近的数据和我们的初步研究结果,我们假设丘脑-TRN-
丘脑回路提供丘脑核团之间的关键连接,因此允许快速
在听觉和其他丘脑皮层通路之间切换。我们打算测试一下
使用解剖学、化学发生学、光学刺激和光学
成像方法在小鼠中,使用切片和体内方法。具体来说,我们将
确定使用多个潜在电路通路中的哪一个来允许听觉、视觉和
听觉丘脑核团相互沟通。接下来,我们将确定是否和
这种丘脑串扰如何影响听觉皮层水平的突触反应。
最后,TRN对交叉模态处理的影响将直接通过光学检查。
调节TRN,同时成像皮层对清醒时组合感觉刺激的反应,
小鼠该项目的成功完成将提供
TRN在听觉丘脑和其他丘脑区域之间的通信中的作用。在
此外,这项工作将奠定基础,更好地了解如何丘脑网状
系统在交流的混乱中崩溃。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DANIEL A LLANO其他文献
DANIEL A LLANO的其他文献
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Super-resolution imaging of brain microvascular changes in a model of Alzheimer Disease
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Examination of the bidirectional relationship between hearing loss and Alzheimer Disease pathology
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- 批准号:
10356939 - 财政年份:2021
- 资助金额:
$ 32.78万 - 项目类别:
Synaptic mechanisms of auditory thalamic cross-modal communication
听觉丘脑跨模式通讯的突触机制
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10320450 - 财政年份:2021
- 资助金额:
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Thalamic reticular nucleus modulation of auditory thalamocortical function
丘脑网状核对听觉丘脑皮质功能的调节
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- 资助金额:
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9020945 - 财政年份:2015
- 资助金额:
$ 32.78万 - 项目类别:
Thalamic reticular nucleus modulation of auditory thalamocortical function
丘脑网状核对听觉丘脑皮质功能的调节
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8951649 - 财政年份:2015
- 资助金额:
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Functional organization of the auditory corticocollicular system
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Functional organization of the auditory corticocollicular system
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8888751 - 财政年份:2015
- 资助金额:
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