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Synaptic mechanisms of auditory thalamic cross-modal communication

听觉丘脑跨模式通讯的突触机制

基本信息

批准号：
10540232
负责人：
DANIEL A LLANO
金额：
$ 32.78万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10540232
关键词：
Acoustics Anatomy Area Attention Auditory Auditory area Auditory system Binding Brain Cell Nucleus Cells Characteristics Chemical Synapse Communication Communication impairment Data Disease Dorsal Dyslexia Electrical Synapse Electrophysiology (science)Environment Failure Genetic Goals Hearing Heart Image In Vitro Lasers Link Maps Measures Medial Medial geniculate body Mediating Modality Modeling Modernization Mus Neurons Optics Pathway interactions Physiological Population Preparation Process Property Rabies Resources Role Scanning Sensory Signal Transduction Slice Stimulus Stream Structure Synapses System Testing Thalamic Nuclei Thalamic structure Thinness Travel Virus Visual Work auditory thalamus autism spectrum disorder awake calcium indicator cognitive change computer studies genetic manipulation imaging approach in vivo inducible Cre lens cortex multimodality multisensory network architecture novel optical imaging pharmacologic response segregation sensory processing disorder sensory stimulus sensory system somatosensory

项目摘要

ABSTRACT Healthy subjects rapidly shift their attention in response to a dynamic sensory environment and changing cognitive demands. Failure to quickly shift perceptual resources between auditory and other modalities has been hypothesized to be a core deficit in both dyslexia and autism. Precisely how the brain shuttles information between sensory systems is not known, but recent work suggests that the thalamus contains circuits that have the capacity to rapidly transition between different sensory modalities. Specifically, the thalamic reticular nucleus (TRN), a thin shell of GABAergic neurons surrounding the thalamus, may serve as a link to allow communication between different areas of the sensory thalamus, a phenomenon we refer to as thalamic “cross- talk.” Based on recent data and our preliminary findings, we hypothesize that thalamo-TRN- thalamic circuits provide critical connections between thalamic nuclei and therefore permit rapid switching between auditory and other thalamocortical pathways. We propose to test this hypothesis using a novel combination of anatomical, chemogenetic, optical stimulation and optical imaging approaches in the mouse, using both slice and in vivo approaches. Specifically, we will determine which of multiple potential circuit pathways is/are used to permit auditory, visual and auditory thalamic nuclei to communicate with each other. Next, we will determine whether and how such thalamic cross-talk influences synaptic responses at the level of the auditory cortex. Finally, the impact of the TRN on cross-modal processing will be directly examined by optically modulating the TRN while imaging cortical responses to combined sensory stimulation in awake mice. Successful completion of this project will provide the first circuit-level characterization of the role of the TRN in communication between the auditory thalamus and other thalamic regions. In addition, this work will lay the groundwork for a greater understanding of how thalamoreticular systems break down in disorders of communication.

摘要