Super-resolution imaging of brain microvascular changes in a model of Alzheimer Disease
阿尔茨海默病模型脑微血管变化的超分辨率成像
基本信息
- 批准号:10430929
- 负责人:
- 金额:$ 42.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:Aerobic ExerciseAgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease brainAlzheimer&aposs disease modelAlzheimer&aposs disease pathologyAlzheimer&aposs disease riskAnatomyAnimal Disease ModelsAnimalsAreaAutomobile DrivingAutopsyBehaviorBiologicalBloodBlood VesselsBlood VolumeBlood capillariesBlood flowBrainBrain DiseasesBrain imagingBrain regionCerebrovascular CirculationCerebrovascular systemChronicCognitionCognitiveCommunitiesCoupledDataDevelopmentDiabetes MellitusDiseaseExerciseFunctional ImagingGoalsHippocampus (Brain)HumanHypertensionIllness impactImageImaging DeviceImaging TechniquesImpaired cognitionIndividualInterventionLifeLongevityMeasuresMicroscopyMusNerve DegenerationObesityPathogenesisPenetrationPhysical ExercisePhysiologyPopulationPublic HealthResearchResolutionRestRisk FactorsScienceSocietiesSpeedStructureTechniquesTherapeutic InterventionTimeTissue imagingTissuesWorkabeta depositionage groupage relatedaging populationangiogenesisbasecardiovascular risk factorcerebral microvasculaturecognitive changecognitive functioneffective therapyhigh riskhistological studiesimaging approachimaging studymicrovascular pathologymiddle agemillimetermouse modelnovelnovel imaging techniquepreservationultrasoundvascular risk factor
项目摘要
Project Summary
Although biomedical science has made remarkable progress in extending the human lifespan,
this lengthening of life has not necessarily been matched by longevity in cognition. Older
individuals are at significantly higher risk for developing Alzheimer Disease (AD). Thus, the rising
numbers of older individuals, coupled with aging-related risk for AD, is rapidly becoming a public
health crisis. It is therefore important that we understand the mechanisms underlying declining
cognitive function in AD. Although many mechanisms underlying cognitive decline in AD have
been proposed, two universal findings motivate the current work: 1) vascular risk factors are a
strong predictor of AD and 2) histopathological studies have shown profound alterations in the
microvasculature of the AD brain. Although these studies point to vascular compromise as a
potential contributory agent of AD-associated cognitive decline, there are currently no techniques
available that permit a detailed assessment of the cerebral microvasculature of deep and
superficial blood vessels in a living animal. Thus, it has not been possible to track vascular
changes over time or to determine the impact of therapeutic interventions on the
cerebral microvasculature. To this end, our team has been developing a novel form of super-
resolution vascular imaging known as ultrasound localization microscopy (ULM). ULM can image
micron-size blood vessels many millimeters deep into the brain, and can capture dynamics of
blood flow (speed, flow uniformity and direction) which are not available using histological studies.
Here, we propose to use ULM to investigate AD-related changes in blood flow dynamics and will
relate them to AD-related changes in behavior in a mouse model of AD. In addition, we will
determine if an intervention known to mitigate AD-related cognitive changes – aerobic exercise
– restores regional cerebral microvasculature dynamics in AD model animals. Successful
completion of this work will not only unveil previously poorly understood changes in microvascular
dynamics with AD, but will also advance a novel imaging technique with broad potential
applications to understand many other disorders of the brain.
项目总结
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('DANIEL A LLANO', 18)}}的其他基金
Examination of the bidirectional relationship between hearing loss and Alzheimer Disease pathology
听力损失与阿尔茨海默病病理学之间双向关系的检查
- 批准号:
10196576 - 财政年份:2021
- 资助金额:
$ 42.15万 - 项目类别:
Examination of the bidirectional relationship between hearing loss and Alzheimer Disease pathology
听力损失与阿尔茨海默病病理学之间双向关系的检查
- 批准号:
10356939 - 财政年份:2021
- 资助金额:
$ 42.15万 - 项目类别:
Synaptic mechanisms of auditory thalamic cross-modal communication
听觉丘脑跨模式通讯的突触机制
- 批准号:
10320450 - 财政年份:2021
- 资助金额:
$ 42.15万 - 项目类别:
Synaptic mechanisms of auditory thalamic cross-modal communication
听觉丘脑跨模式通讯的突触机制
- 批准号:
10540232 - 财政年份:2021
- 资助金额:
$ 42.15万 - 项目类别:
An upright multiphoton microscope for biomedical research applications
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- 批准号:
9274589 - 财政年份:2017
- 资助金额:
$ 42.15万 - 项目类别:
Thalamic reticular nucleus modulation of auditory thalamocortical function
丘脑网状核对听觉丘脑皮质功能的调节
- 批准号:
9096739 - 财政年份:2015
- 资助金额:
$ 42.15万 - 项目类别:
Functional organization of the auditory corticocollicular system
听觉皮质皮质系统的功能组织
- 批准号:
9020945 - 财政年份:2015
- 资助金额:
$ 42.15万 - 项目类别:
Thalamic reticular nucleus modulation of auditory thalamocortical function
丘脑网状核对听觉丘脑皮质功能的调节
- 批准号:
8951649 - 财政年份:2015
- 资助金额:
$ 42.15万 - 项目类别:
Functional organization of the auditory corticocollicular system
听觉皮质皮质系统的功能组织
- 批准号:
10584167 - 财政年份:2015
- 资助金额:
$ 42.15万 - 项目类别:
Functional organization of the auditory corticocollicular system
听觉皮质皮质系统的功能组织
- 批准号:
8888751 - 财政年份:2015
- 资助金额:
$ 42.15万 - 项目类别:
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