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Functional organization of the auditory corticocollicular system

听觉皮质皮质系统的功能组织

基本信息

批准号：
9020945
负责人：
DANIEL A LLANO
金额：
$ 37.86万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9020945
关键词：
Acoustic Stimulation Aphasia Area Auditory Auditory area Auditory system Autistic Disorder Brain Cell Nucleus Cells Characteristics Clinical Communication Communication impairment Cues Data Deposition Disease Dyslexia Electric Stimulation Environment Flavoproteins Fluoro-Gold Foundations Glutamates Goals Health Hearing Hearing problem Human Image Individual Inferior Colliculus Injection of therapeutic agent Knowledge Label Language Lasers Light Maps Microinjections Mus Neurons Optics Output Pathway interactions Patients Pattern Physiological Physiology Play Preparation Process Property Role Sensory Process Shapes Signal Transduction Slice Stream Structure Synapses System Techniques Testing Tracer Whole-Cell Recordings Work brain pathway cell type in vivo mouse model neuromechanism novel optical imaging photolysis reconstruction relating to nervous system sound therapeutic development

项目摘要

DESCRIPTION (provided by applicant): The ability to extract meaning from sounds, even when degraded, is critical for normal hearing. A key strategy employed by the auditory system during acoustically-challenging situations is the use of contextual cues to disambiguate cluttered signals. Importantly, many patients with language-related disorders, such as aphasia, autism and dyslexia, have difficulties harnessing such contextual cues. The neural mechanisms by which high-level information can be used to shape lower-level sensory processing are not yet known. A potential substrate for this type of processing is the massive top-down projection system emanating from virtually every level of the auditory system. In this project, we will provide a functional characterization of one of the largest of these projections: the auditory corticocollicular system. The corticocollicular system can rapidly and profoundly change the tuning of neurons in the inferior colliculus, but key aspects about its organization are not known. We hypothesize that this system comprises at least two functionally distinct sub- systems; one from cortical layer 5 and another from cortical layer 6. Using the mouse model, the cortical distribution of layer 5 and 6 neurons that project to small regions of the inferior colliculus willbe reconstructed and compared. Our early data suggest that input from layer 6 emanates from a more widespread area than layer 5 and tends to predominate in the non-primary parts of the auditory cortex. In addition, we will combine in vivo transcranial flavoprotein autofluoresence imaging with quantitative neuronal reconstructions to compare the projection patterns of layer 5 vs. layer 6 cortical projections to the inferior colliculus. Finally, using a novel corticocolliculr brain slice preparation and laser photostimulation, we will compare the synaptic properties of layer 5 and 6 corticocollicular synapses. Successful completion of this project will provide the first circuit-level characterization of this important pathway and will lay the groundwork for a greater understanding of how top-down modulatory systems break down during disorders of communication.