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Thalamic reticular nucleus modulation of auditory thalamocortical function

丘脑网状核对听觉丘脑皮质功能的调节

基本信息

批准号：
9096739
负责人：
DANIEL A LLANO
金额：
$ 19.83万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-06-23 至 2018-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9096739
关键词：
Acoustics Action Potentials Address Amygdaloid structure Attention Auditory Auditory area Brain Calcium Calcium Channel Blockers Cell Nucleus Cells Cognitive Development Disease Dyslexia Electrophysiology (science)Emotional Flavoproteins Future Health Hearing Image Individual Inferior Colliculus Investigation Lasers Lead Light Literature Location Measurement Measures Medial geniculate body Mus Neurons Normal Range Optics Output Pathway interactions Physiology Play Population Prefrontal Cortex Preparation Process Research Personnel Role Schizophrenia Sensory Process Series Signal Transduction Slice Structure Synapses System T-Type Calcium Channels Techniques Testing Thalamic structure Time Tinnitus Work basal forebrain base capsule cognitive function design fluorescence imaging frontal lobe gamma-Aminobutyric Acid insight meetings neurophysiology neurotransmission novel patch clamp relating to nervous system response selective attention sound synaptic depression targeted treatment tool transmission process

项目摘要

DESCRIPTION (provided by applicant): The thalamic reticular nucleus (TRN) is a capsule of GABAergic neurons that partially envelops the thalamus and has been speculated to play a role in normal cognitive functions, such as selective attention, and in pathological states, such as tinnitus and schizophrenia. Therefore, understanding the function of the auditory portion of the TRN will unlock secrets not only about normal hearing, but also provide insights about how thalamocortical systems become dysfunctional in disease. Unfortunately, the impact of the TRN on sensory processing has been particularly inscrutable because of its small size and deep location. Until now, there has not been an experimental preparation that permitted measurement of thalamic and cortical activity at the cellular level while allowing simultaneous manipulation of the TRN and afferent input to the thalamus. We have recently overcome this hurdle by developing a brain slice preparation in the mouse that contains robust connectivity between the inferior colliculus, auditory thalamus, auditory TRN and the auditory cortex (Llano et al. J Neurophysiology 2014, 111(1):197). Herein, we combine the use of this new preparation with a range of optical, electrophysiological and pharmacological tools to test a novel hypothesis: that the TRN produces paradoxical rate- dependent enhancement of the transmission of neural signals as they pass through the colliculo-thalamocortical pathway. This hypothesis is based upon recent findings that the auditory TRN receives non-reciprocal input from wide-ranging neural structures, such as the frontal cortex and amygdala, and that GABAergic input from the TRN produces short windows of hyperexcitability in thalamic neurons by de-inactivating T-type calcium currents. Successful completion of this work will open the doors to future studies that examine the impact of the frontal cortex and amygdala on auditory thalamocortical systems through the TRN, and therefore will shed light on how cognitive and emotional states influence acoustic processing.