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Functional organization of the auditory corticocollicular system

听觉皮质皮质系统的功能组织

基本信息

批准号：
10584167
负责人：
DANIEL A LLANO
金额：
$ 37.62万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10584167
关键词：
Acoustics Address Anatomy Area Auditory Auditory Perception Auditory area Auditory system Axon Behavioral Brain Brain region Cells Chemicals Classification Cognition Disorders Collection Corpus striatum structure Data Dendrites Disease Distal Dyslexia Electrophysiology (science)Environment Funding Geometry Goals Hearing Heterogeneity Image Inferior Colliculus Language Lateral Location Machine Learning Maps Measures Mediating Mental Depression Metabolic Modernization Molecular Morphology Mus Neurons Optics Organizational Productivity Output Pathway interactions Pattern Perception Periodicals Physiological Play Population Process Property Role Sampling Secure Sensory Signal Transduction Slice Source Spatial Distribution Speech Stimulus Stream Structure Support System Synapses System Techniques Thalamic structure Work auditory pathway autism spectrum disorder awake cell type experience experimental study hearing impairment imaging approach machine learning algorithm molecular marker mosaic mouse model multisensory neurochemistry novel postsynaptic response sensory integration sensory stimulus sensory system sound striosome tool two-photon virtual

项目摘要

PROJECT SUMMARY The ability to decipher meaning from degraded sounds is critical for everyday hearing. A key strategy to extract buried signals is to integrate stored acoustic representations with the incoming sound stream. Such top- down/bottom-up interaction appears to be a fundamental feature in sensory systems. Indeed, disruptions of such processes may be involved in disorders such as autism and dyslexia. Unfortunately, little is known about the mechanisms by which top-down information modulates sensory function. Here, we propose a circuit-level analysis of a massive descending pathway from the auditory cortex to the inferior colliculus (IC) which is thought to be important for top-down modulation. Although this pathway has been shown to be critical for many processes important for auditory perception, how it supports such diversity of function is not known. During the last funding period, we uncovered an unexpected degree of heterogeneity in this pathway. For example, we observed that neurons in the two cortical layers from which this pathway is derived, layer 5 (L5) and layer 6 (L6), have distinct physiological, morphological and connectivity patterns. L5 neurons receive direct thalamic input, burst when stimulated and send projections containing giant terminals to the lateral cortex (LC) of the IC. L6 neurons receive sparse local input, but sample from a broad area of the cortex and end in small terminals on the distal rim of the LC. These data suggest that L5 neurons send a rapid and secure signal to the LC, while L6 neurons modulate LC function based on broad multisensory integration. We also found that the corticocollicular projections interdigitate with periodic neurochemical clusters (“patches” and “matrix”) in the LC and that the presence of this patch/matrix system governs virtually all input and output to and from this structure. These findings raise several questions that will be addressed in the current proposal. First, how does the L5/L6 system interface with the neurochemical and connectional mosaic comprising the LC? To address this question, we will use machine learning tools to parse the neurochemical cell classes in the LC, and then use a novel form of Cre-dependent trans-synaptic tracing to map parallel pathways originating in L5 or L6 and ending at one of the many targets of the LC. Second, we will examine the impact of L5 and L6 terminals on LC neurons using optical and electrophysiological approaches to determine the relative impacts and geometry of these inputs. Third, we will determine what messages are sent by L5 and L6 to the LC by imaging their axons in response to auditory and non-auditory stimulation using a novel microprism-based two-photon imaging approach in awake mice. We can thus determine if L5 and L6 send distinct messages to the LC, and whether the messages vary across the patch/matrix topography. Therefore, by leveraging the patch/matrix organization to parse the dense thicket of inputs and outputs to and from the LC, this work will shed light on mechanisms of top-down modulation in the auditory system. In doing so, it will provide a paradigm for understanding diseases involving disruptions in top-down/bottom-up integration, such as dyslexia and autism.

项目总结

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex.

DOI：
10.1007/s00424-017-2037-4
发表时间：
2017-12
期刊：
Pflugers Archiv : European journal of physiology
影响因子：
0
作者：
Ibrahim BA;Wang H;Lesicko AMH;Bucci B;Paul K;Llano DA
通讯作者：
Llano DA

Two-photon microscope using a fiber-based approach for supercontinuum generation and light delivery to a small-footprint optical head.

双光子显微镜使用基于光纤的方法来生成超连续谱并将光传输到小型光学头。

DOI：
10.1364/ol.381571
发表时间：
2020
期刊：
Optics letters
影响因子：
3.6
作者：
Zhao,Youbo;Maguluri,Gopi;DanielFerguson,R;Tu,Haohua;Paul,Kush;Boppart,StephenA;Llano,DanielA;Iftimia,Nicusor
通讯作者：
Iftimia,Nicusor

Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity.

TC-2153对富含纹状体的蛋白酪氨酸磷酸酶的药理抑制作用降低了海马兴奋性和癫痫发作倾向。

DOI：
10.1111/epi.17192
发表时间：
2022-05
期刊：
EPILEPSIA
影响因子：
5.6
作者：
Walters, Jennifer M.;Kim, Eung Chang;Zhang, Jiaren;Jeong, Han Gil;Bajaj, Archit;Baculis, Brian C.;Tracy, Gregory C.;Ibrahim, Baher;Christian-Hinman, Catherine A.;Llano, Daniel A.;Huesmann, Graham R.;Chung, Hee Jung
通讯作者：
Chung, Hee Jung

Auditory system dysfunction in Alzheimer disease and its prodromal states: A review.