Does When You Exercise Matter? A Randomized Trial Comparing the Effect of Morning versus Evening Aerobic Exercise on Weight Loss and Compensatory Behaviors

运动时间重要吗？

• 批准号: 10296553
• 负责人: VICTORIA A CATENACCI
• 金额: $ 66.54万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-17 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10296553
• 关键词: Adherence; Adult; Aerobic Exercise; Affect; Attention; Attenuated; Behavior; Behavioral; Body Composition; Body Weight; Body Weight Changes; Body Weight decreased; Body mass index; Burn injury; Calories; Characteristics; Circadian Rhythms; Cues; Data; Data Analyses; Data Set; Desire for food; Development; Diet; Dose; Energy Intake; Energy Metabolism; Ensure; Equilibrium; Exercise; Exhibits; Fatty acid glycerol esters; Financial compensation; Hunger; Indirect Calorimetry; Individual; Intake; Intervention; Lead; Life Style; Literature; Measures; Methods; Nutritional; Obesity; Overweight; Participant; Pathway interactions; Patients; Pattern; Phase; Physical activity; Physiological; Public Health; Randomized; Regulation; Research; Sleep; Supervision; Time; Weight; Weight Gain; attenuation; base; circadian; design; doubly-labeled water; energy balance; exercise intervention; exercise prescription; exercise training; food craving; innovation; insight; intervention effect; novel; obese person; obesity treatment; prevent; primary endpoint; primary outcome; prospective; randomized trial; response; sedentary; success; total energy expenditure; trial comparing

PROJECT SUMMARY & ABSTRACT Does what time of day you exercise matter for weight loss? The objective of this proposal is to determine the effect of an equivalent dose of morning versus evening aerobic exercise on change in body weight, energy intake (EI), and components of energy expenditure (EE) in adults with overweight or obesity. Nearly two-thirds of US adults who attempt to lose weight engage in exercise as a strategy for weight loss. However, weight loss from exercise alone is often substantially less than predicted based on the calories burned in exercise. This is due to compensatory changes that occur in response to exercise (e.g. increases in EI and decreases in non-exercise EE) that limit the energy deficit produced by exercise. Thus, strategies that reduce the compensatory response could enhance the weight loss efficacy of exercise. Preliminary data suggests that morning exercise may limit development of compensation and thus be superior to evening exercise for weight loss. In a secondary data analysis of a 10-month supervised exercise intervention in adults with overweight or obesity, individuals who predominantly exercised in the morning exhibited three-fold greater weight loss compared to individuals who predominantly exercised in the evening, despite equivalent exercise EE and adherence. Further, 81% of morning exercisers achieved ≥5% weight loss, compared to 36% of evening exercisers. There was also evidence of differences in compensation. Despite no intervention on diet, morning exercisers decreased EI across the intervention, while evening exercisers increased EI. Morning exercisers increased total daily energy expenditure (TDEE) proportionately to the EE of exercise, while evening exercisers demonstrated attenuated increases in TDEE. However, these results were from a retrospective analysis in which participants were categorized by the time of day in which they predominantly performed exercise sessions. A rigorously designed randomized trial is needed to confirm these novel findings. In the proposed study, adults with overweight or obesity will be randomized to 7 months of supervised aerobic exercise (2000 kcal/week) performed either in the morning or the evening, and then followed for an additional 6 months. The central hypothesis is that morning exercise will result in greater weight loss as compared to evening exercise due to attenuated development of compensatory changes in EI and EE. The study will compare the effects of morning versus evening exercise on changes in body weight and body composition (Aim 1), changes in EI and appetite (Aim 2), changes in EE, non-exercise physical activity, and sedentary time (Aim 3), and changes in meal timing and sleep (Exploratory Aim 4). The approach is rigorous and innovative as exercise will be prescribed based on EE using indirect calorimetry, free- living TDEE and EI will be measured objectively (doubly-labeled water), and 24-hr patterns of physical activity, sedentary time, meal timing, and sleep will be measured to understand pathways through which exercise timing alters energetics and weight loss. The study is significant as it could identify a practicable strategy to enhance weight loss from exercise and provide insight on how timing of exercise impacts compensatory behaviors.

项目概要和摘要 你每天锻炼的时间对减肥有影响吗？本提案的目的是确定 早晚等量有氧运动对体重、能量摄入影响 (EI)以及超重或肥胖成年人的能量消耗（EE）组成。近三分之二的美国 试图减肥的成年人把锻炼作为减肥的一种策略。然而，体重减轻， 单独锻炼通常比基于锻炼中燃烧的卡路里所预测的要少得多。这是由于 运动后发生的代偿性变化（如EI增加，非运动时EI减少） EE），限制运动产生的能量不足。因此，减少补偿反应的策略 可增强运动减肥功效。初步数据显示，晨练可能会限制 发展的补偿，从而上级晚上锻炼减肥。在次要数据中， 对超重或肥胖成年人进行为期10个月的监督运动干预的分析， 主要在早上锻炼的人的体重减轻是那些在早上锻炼的人的三倍。 主要在晚上锻炼，尽管锻炼EE和坚持性相当。此外，81%的 晨练者体重减轻≥5%，而晚间锻炼者为36%。还有证据 补偿的差异。尽管没有对饮食进行干预，但晨练者在整个研究中降低了EI。 干预，而晚上锻炼增加EI。晨练增加了每日总能量消耗 （TDEE）与运动的EE成比例，而晚间锻炼者表现出减弱的增加， TDEE。然而，这些结果来自一项回顾性分析，其中参与者被分类为 他们主要进行锻炼的时间。一项严格设计的随机试验 需要证实这些新发现。在这项拟议的研究中，超重或肥胖的成年人将被 随机分为7个月的监督有氧运动（2000千卡/周），无论是在早上或 晚上，然后再随访6个月。核心假设是晨练会导致 与晚间锻炼相比，由于代偿性运动的发展减弱， 本研究将比较晨练与晚间锻炼对EI和EE变化的影响， 体重和身体成分（目标1），EI和食欲变化（目标2），EE变化，非运动 体力活动和久坐时间（目标3），以及进餐时间和睡眠的变化（探索性目标4）。的 方法是严格和创新的，因为运动将根据EE使用间接热量测定法，免费- 将客观测量活体TDEE和EI（双标记水），以及24小时体力活动模式， 久坐时间，用餐时间和睡眠将被测量，以了解运动时间的途径。 改变能量和减肥。这项研究很有意义，因为它可以找到一个切实可行的策略， 运动减肥，并提供关于运动时间如何影响代偿行为的见解。