Project 3 -- MIDUS Biomarker Project
项目3——MIDUS生物标志物项目
基本信息
- 批准号:10559178
- 负责人:
- 金额:$ 260.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-07-25 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:Activities of Daily LivingAdultAffectAgeAgingAlzheimer&aposs disease related dementiaAmyloid beta-42Amyloid beta-ProteinBehaviorBehavioralBiologicalBiological FactorsBiological MarkersBiologyCOVID-19 pandemicCardiovascular systemChronicChronic stressClinic VisitsCognitiveCollectionCommunitiesConflict (Psychology)DataData CollectionDisadvantagedDiseaseElderlyExposure toGenomicsGoalsHealthHealth StatusHearing TestsIncomeIndividualInflammationInflammatoryLightLinkMeasuresMediatingMediator of activation proteinMental HealthMusculoskeletalNeurosciencesNeurosecretory SystemsOutcomeParticipantPathway interactionsPatternPersonal SatisfactionPersonsPhysiologicalPlayProcessPsychosocial FactorPublicationsRaceRegulationResearch DesignRiskRoleSamplingScientific Advances and AccomplishmentsSocial supportSocioeconomic FactorsSocioeconomic StatusStressSurveysSystemTestingTimeTreatment/Psychosocial EffectsTwin Multiple BirthVisitWorkaffective neuroscienceage groupage relatedbiopsychosocialclinically significantcognitive testingcohortcomparativedesignexperiencefollow-upfunctional declinefunctional disabilityglucose metabolismhealth disparityhuman old age (65+)innovationmiddle ageneurofilamentpopulation basedprospectivepsychosocialpsychosocial resourcesracial disparitysexsocialsocial integrationsociodemographic factorssocioeconomic disadvantagesocioeconomic disparitysocioeconomicstau-1
项目摘要
ABSTRACT – BIOMARKER PROJECT
The Biomarker Project plays a central role in the MIDUS efforts to understand aging as an integrated
biopsychosocial process. Our prior biomarker data have received widespread engagement from the scientific
community: 403 publications have been generated, 162 of which appeared since 2019. The goal going forward
is to build on this momentum by collecting a 2nd wave of longitudinal data on the Refresher subsample (n=647),
and a 4th wave of longitudinal data on the Core subsamples (n=630), for a total projected N=1,277. We will
repeat our comprehensive battery of biomarkers (neuroendocrine, inflammatory, glucose metabolism,
cardiovascular, musculoskeletal) plus add new measures related to Alzheimer’s Disease and Related
Dementias (ADRD), including amyloid beta (Aβ40, Aβ42), neurofilament light (NFL), and P-tau, along with a
new measure of chronic inflammation (suPAR). We will also add the Montreal Cognitive Assessment (MoCA)
and a hearing test. We will investigate hypotheses about the effects of socioeconomic and psychosocial
disadvantage on subsequent change in biology, predicting that those exposed to greater cumulative adversity
will show heightened biological risk over time and greater functional impairment. We will also investigate the
role of psychosocial resources in moderating (mitigating) against the adverse health consequences of
socioeconomic and racial disparities. We will exploit the MIDUS design involving two national samples (Core,
Refresher) unfolding in time to examine widening socioeconomic status differential in health outcomes in
same-aged groups across different historical periods. Included in these analyses will be stress exposures
related to the Great Recession (previously assessed) and newly assessed hardships of the COVID-19
pandemic. Viewed comparatively, three key features distinguish the MIDUS Biomarker Project from other U.S.
studies. First, it will provide 3 waves of biological data over 20 years in the Core national sample and 2 waves
of biological data over 10 years in the Refresher national sample, all obtained on mid-life adults at baseline.
Second, the biomarkers collected in MIDUS are far richer than any other U.S. population-based sample. Third,
the extensive survey data of MIDUS – encompassing decades of prospective information on socioeconomic,
psychosocial, and behavioral aspects of participants’ lives -- provide unique opportunities for testing how these
factors combine to account for who has maintained healthy biological regulation and functional health across
time, while others have shifted toward clinically significant biological risk, or moved from pre-disease to disease
states. The MIDUS biomarker measures are also prominently featured in other projects (Survey, Daily,
Genomics) of this U19 application as well as the components (Cognitive, Affective Neuroscience, ADRD
Neuroscience) of the Ancillary U01 application.
摘要-生物标志物项目
生物标志物项目在MIDUS努力将衰老理解为一个综合的
生物心理社会过程我们之前的生物标志物数据已经得到了科学界的广泛参与。
社区:已生成403篇出版物,其中162篇自2019年以来出现。前进的目标
是通过收集复习者子样本(n=647)的第二波纵向数据来建立这种势头,
以及关于岩芯子样本的纵向数据的第四波(n=630),总的预计N= 1,277。我们将
重复我们全面的生物标志物电池(神经内分泌,炎症,葡萄糖代谢,
心血管、肌肉骨骼),并增加与阿尔茨海默病和相关疾病相关的新措施
痴呆症(ADRD),包括淀粉样蛋白β(Aβ40、Aβ42)、神经丝轻蛋白(NFL)和P-tau,沿着
慢性炎症的新指标(suPAR)。我们还将增加蒙特利尔认知评估(莫卡)
还有听力测试我们将调查关于社会经济和心理社会影响的假设
不利的后续变化的生物学,预测那些暴露于更大的累积逆境,
随着时间的推移,会显示出更高的生物风险和更大的功能障碍。我们还将调查
社会心理资源在减轻(减轻)
社会经济和种族差异。我们将利用涉及两个国家样本(核心,
复习)及时展开,以审查在健康结果方面不断扩大的社会经济地位差异,
不同历史时期的同龄人。这些分析将包括压力暴露
与大衰退(以前评估)和新评估的COVID-19困难有关
流行病相比之下,MIDUS生物标志物项目与美国其他生物标志物项目有三个主要特点。
问题研究首先,它将提供Core国家样本中20年的3波生物数据,
更新国家样本中10年以上的生物数据,所有数据都是在基线时从中年人身上获得的。
其次,MIDUS收集的生物标志物比任何其他美国人口样本都要丰富得多。第三、
MIDUS的广泛调查数据----包括几十年的社会经济前瞻性信息,
参与者生活的心理社会和行为方面-提供了独特的机会来测试这些
这些因素联合收割机共同决定了谁在整个生命周期中保持了健康的生物调节和功能健康。
时间,而其他人已经转向临床显著的生物风险,或从疾病前转移到疾病
states. MIDUS生物标志物测量在其他项目中也很突出(调查,每日,
基因组学)以及组件(认知、情感神经科学、ADRD
神经科学)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CAROL D. RYFF其他文献
CAROL D. RYFF的其他文献
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{{ truncateString('CAROL D. RYFF', 18)}}的其他基金
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