Core A -- Administrative Core

摘要-行政核心 行政核心的职责包括全面领导MIDUS以及监督数据 收集、管理和提供研究数据。将由校长领导 研究者（PI）和执行指导委员会（ESC），由以下人员组成： 项目和核心。他们将监督有关执行和完成所述 U19和辅助AD/ADRD U 01应用程序的目标。主要领导任务包括： 在实现研究资助目标方面取得的进展;促进有效和协同的沟通 跨项目和核心;组织和主持共同研究者、公众用户和 数据监查委员会（DMC）;确保研究执行中的质量控制;管理合同 协议、资金分配和年度报告;以及在需要时解决争端。Day-to-day 职责由威斯康星大学麦迪逊分校的行政核心联合领导人集中管理，包括协调 跨项目收集数据。四个项目包括在这个U19（调查，每日，生物标志物，基因组学） 三个项目包括在辅助AD/ADRD U 01（认知，情感神经科学，ADRD 神经科学）。将收集所有数据（6年期间），涵盖下一波复习 (MR2)和核心（M4）国家样本以及来自密尔沃基的目标非裔美国人样本。的 行政核心将监督和外地这一复杂的任务，这需要仔细排序的招聘， 项目对项目，结合项目特定调查人员之间的及时沟通。这些目标将 通过一个创新的在线行政核心数据库系统， 实时提供项目之间的分配、参与和联系信息。管理核心还将创建 并向研究界提供高质量的数据集，并提供全面、用户友好的文档。 这些目标将通过元数据惯例和使用由 研究文档标准，称为数据文档倡议（DDI）。在这些努力的基础上， Admin Core将继续加强一个独一无二的在线门户网站，帮助用户进行智能搜索 功能、协调工具和自定义数据提取，从而支持纵向和 MIDUS的生物心理社会综合目标。敏感数据（例如来自基因组学和神经科学 项目）将通过受限制的访问程序和由管理员管理的存储库提供 核心管理核心联合领导人将通过演示文稿和网络研讨会促进公众使用MIDUS数据集， 描述如何访问和使用NACDA和门户数据。最后，管理核心将监督和 管理与MIDUS外部数据资源的链接，例如定期死亡率更新，医疗保险记录， MIDUS参与者的地理编码、药物使用和职业描述符。

ABSTRACT – ADMINISTRATIVE CORE The Administrative Core’s responsibilities include overall leadership of MIDUS as well as oversight of data collection, management, and delivery of research data. Leadership will be provided by the Principal Investigator (PI) and Executive Steering Committee (ESC), consisting of the Leaders/Co-Leaders of the Projects and Cores. They will oversee major decisions regarding implementation and completion of the stated aims of the U19 and the Ancillary AD/ADRD U01 applications. Primary leadership tasks include: monitoring progress in achieving funded objectives of the research; nurturing effective and synergistic communication across Projects and Cores; organizing and hosting meetings among co-investigators, public users, and the Data Monitoring Committee (DMC); insuring quality control in execution of the research; managing contractual agreements, allocation of funds, and yearly reporting; and resolving disputes, when needed. Day-to-day responsibilities are centrally managed by Admin Core Co-Leaders at UW-Madison, including coordination of data collection across Projects. Four Projects are included in this U19 (Survey, Daily, Biomarker, Genomics) and three Projects are included in the Ancillary AD/ADRD U01 (Cognitive, Affective Neuroscience, ADRD Neuroscience). Data for all will be collected (over a 6-year period) that covers the next wave of the Refresher (MR2) and the Core (M4) national samples as well as targeted African American samples from Milwaukee. The Admin Core will oversee and field this complex task, which requires careful sequencing of recruitment from Project to Project, combined with timely communication among Project-specific investigators. Such goals will be accomplished through an innovative online Administrative Core database system that manages respondent assignment, participation, and contact information across Projects in real-time. The Admin Core will also create and deliver to the research community high quality datasets with comprehensive, user-friendly documentation. These goals will be advanced via metadata conventions and use of cutting-edge technology supported by a research documentation standard called the Data Documentation Initiative (DDI). Building off these efforts, the Admin Core will continue to enhance a one-of-a-kind online Portal that aids users with intelligent search functions, harmonization tools, and custom data extracts, thereby supporting the longitudinal and biopsychosocial integrative objectives of MIDUS. Sensitive data (such as from Genomics and Neuroscience Projects) will be made available via restricted access procedures and repositories managed by the Admin Core. Admin Core Co-Leaders will facilitate public use of MIDUS datasets via presentations and webinars that describe how to access and work with the NACDA and Portal data. Finally, the Admin Core will oversee and manage linkages to external data resources to MIDUS, such as regular mortality updates, Medicare records, geo-coding, medication usage, and occupational descriptors of MIDUS participants.