Integrative Pathways to Health and Illness

抽象-MIDUS总体规划 美国中年(MIDUS)国家纵向研究自1995年以来一直在进行。MIDUS是唯一 全国性的研究集中在基线年龄范围较大的中年人群。MIDUS还拥有不同寻常的深度 心理社会、生物标记物、基因组和神经科学评估，从而允许重点关注神经生物学 社会人口学和心理社会因素影响发病率和死亡率的机制和途径 死亡率。此应用程序旨在对MIDUS刷新样本进行第二波数据收集 (MR2)以及关于核心样本的第四波数据收集(M4)，包括这两个项目的所有项目。四 项目(调查、每日日记、生物标记、基因组学)是U19竞争延续应用程序的一部分， 这与治疗阿尔茨海默病(AD)和相关痴呆(ADRD)的辅助U01应用程序有关 这将研究认知衰退、情绪调节、大脑老化及其相互作用的中年前驱症状。 以前的大部分工作也是纵向的，尽管现在包括了新的ADRD神经科学和生物标记物。 总体而言，拟议的活动涉及5200多名美国成年人，将得到行政核心的支持 负责协调跨项目的数据收集，并提供高质量、有良好记录的数据；a BioCore，确保生物标志物数据收集的质量控制，并就生物标志物的使用提供指导； 以及提供多个主题研讨会的统计核心(使用基因组对纵向变化进行建模 数据，将MIDUS链接到其他数据集)。在拟议的科学中反复出现的科学主题是健康 利用MIDUS提供的丰富的生物、心理和社会数据审查了不平等和种族差异，包括 对多波压力暴露的广泛评估，从而提供了 累积的逆境。MIDUS还以其对心理和社会问题的全面评估而闻名 行为保护性因素，从而推进了对面对挑战的韧性的研究。随着年龄的增长而老化 不断变化的历史阶段是MIDUS的另一个关键主题，过去对 大衰退，以及未来，新的平行关注新冠肺炎大流行的困难。在以下方面 在科学参与方面，MIDUS是美国国家档案馆下载次数最多的研究 计算机化的老龄化数据(NACDA)。科学界的广泛使用(26,000+公众 已经出版了1,617份出版物，涉及38个实质性领域。强调这一势头 在MIDUS背后，这些产品中有一半以上是在当前资金周期内发表的期刊论文 (2016-至今)。

ABSTRACT – MIDUS OVERALL PLAN The Midlife in the U.S. (MIDUS) national longitudinal study has been ongoing since 1995. MIDUS is the only national study focused on midlife with a wide age expanse at baseline. MIDUS also has unusual depth in its psychosocial, biomarker, genomic, and neuroscience assessments, thus permitting a focus on neurobiological mechanisms and pathways through which sociodemographic and psychosocial factors influence morbidity and mortality. This application aims to conduct a 2nd wave of data collection on the MIDUS Refresher sample (MR2) as well as a 4th wave of data collection on the Core sample (M4), including all projects in both. Four projects (Survey, Daily Diary, Biomarkers, Genomics) are part of this U19 competing continuation application, which is linked with an Ancillary U01 application on Alzheimer’s Disease (AD) and Related Dementias (ADRD) that will examine midlife precursurs to cognitive decline, emotion regulation, brain aging, and their interplay. Much of that prior work is also longitudinal, although it now includes new ADRD neuroscience and biomarkers. Overall, the proposed activities involve over 5,200 U.S. adults that will be supported by an Administrative Core responsible for orchestrating cross-project data collection and delivering high-quality, well-documented data; a BioCore that ensures quality control in biomarker data collection and offers guidance on use of biomarkers; and a Statistics Core that provides workshops on multiple topics (modeling longitudinal change, using genomic data, linking MIDUS to other datasets). Recurring scientific themes in the proposed science are health inequalities and racial disparities examined with the rich biopsychosocial data available in MIDUS, including wide-ranging assessments of stress exposures across multiple waves, thereby providing indicators of cumulative adversity. MIDUS is also known for its comprehensive assessments of psychosocial and behavioral protective factors, thereby advancing research on resilience in the face of challenge. Aging on a changing historical stage is another key theme in MIDUS exemplified by a past focus on hardships of the Great Recession, and going forward, a new parallel focus on hardships of the COVID-19 pandemic. In terms of scientific engagement, MIDUS is the most frequently downloaded study at the National Archive of Computerized Data on Aging (NACDA). Widespread usage from the scientific community (26,000+ public users) has culminated in 1,617 publications covering 38 substantive domains. Underscoring the momentum behind MIDUS, more than half of these products are journal articles published during the current funding cycle (2016-present).