Clinical and Translational Science Award

临床和转化科学奖

• 批准号: 10665627
• 负责人: Robin J. Mermelstein
• 金额: $ 371.04万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665627
• 关键词: Acceleration; Address; Automobile Driving; Basic Science; Chicago; Clinical; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Collaborations; Communities; Community Health; Complex; Data; Data Sources; Development; Discipline; Dissemination and Implementation; Education; Ethnic Origin; Evaluation; Foundations; Funding; Goals; Health; Health Personnel; Health Sciences; Illinois; Individual; Industry; Informatics; Institution; Longevity; Methods; Minority Groups; Mission; Modeling; Movement; Outcome; Patients; Persons; Policies; Policy Maker; Population; Population Heterogeneity; Positioning Attribute; Postdoctoral Fellow; Process; Reproducibility; Research; Resources; Science; Scientist; Site; Special Population; System; Training; Training Programs; Translational Research; Translations; Underserved Population; United States National Institutes of Health; Universities; Vulnerable Populations; Workforce Development; catalyst; clinical center; clinical translation; college; community engaged research; community engagement; graduate student; implementation science; improved; informatics infrastructure; innovation; member; method development; multi-site trial; multidisciplinary; multimodal data; population health; programs; recruit; social health determinants; success; translational barrier; translational pipeline

The University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS) seeks to catalyze translational research, locally and nationally, as part of a national network to improve individual and population health. Since our initial funding by the NIH in 2009, the CCTS has been a catalyst for mobilizing institutional support and resources to enhance clinical translational research and expand multidisciplinary training programs to increase workforce diversity and promote team science. The overarching goal—and driving focus—of the CCTS is to improve population health, particularly among minorities and underserved populations. Our high- quality multidisciplinary clinical and translational research, spanning T1-T4 and paired with strengths in community engagement and implementation science and appreciation for the social determinants of health, help to accelerate discoveries into practice and policy. Building on our organizational foundation and record of success, the UIC CCTS is well-positioned to make substantial contributions by collaborating with other hubs, supporting national CTSA activities, and making unique contributions to community-engaged research with vulnerable and underserved populations. As we move forward, we will continue to develop streamlined processes and resources to facilitate research processes and aid collaboration; to develop and prepare a translational science workforce that is multidisciplinary and comfortable in team science; to use innovative informatics solutions to advance translational research; and to have ready-to-deploy systems to respond rapidly to innovative, collaborative projects. We will achieve our objectives through the following global specific aims: 1) Develop a skillful and diverse translational workforce to conduct multidisciplinary team science and advance translation of discoveries; 2) Engage a broad range of stakeholders in clinical translational research, including patients, community leaders, health care providers and clinicians, industry and policy makers; and further support collaboration among the CTSA hubs; 3) Integrate, support, and accelerate clinical translational research across the full translational spectrum with multiple disciplines and with diverse populations across the lifespan; 4) Promote advances in study and development of methods and processes of conducting translational science that will enable advances in translation; and 5) Support the use and advance of innovative informatics solutions to advance translational research and to help train the CTSA workforce. These aims will direct our course over the next five years, as we further evolve the clinical and translational enterprise, contribute to the CTSA network, and advance the health of the people of Illinois and the nation.

伊利诺伊大学芝加哥分校（UIC）临床和转化科学中心（CCTS）旨在催化 转化研究，地方和国家，作为国家网络的一部分，以改善个人和人口 健康自2009年NIH为我们提供初始资金以来，CCTS一直是动员机构 支持和资源，以加强临床转化研究和扩大多学科培训计划 增加员工多样性，促进团队科学。的总体目标和驱动重点， CCTS旨在改善人口健康，特别是少数民族和服务不足人口的健康。我们的高- 高质量的多学科临床和转化研究，跨越T1-T4，并与以下方面的优势相结合： 社区参与和实施科学以及对健康社会决定因素的认识，帮助 加速将发现转化为实践和政策。在我们的组织基础和 成功，UIC CCTS处于有利地位，通过与其他中心合作， 支持国家CTSA活动，并为社区参与的研究做出独特的贡献， 弱势群体和得不到充分服务的群体。在我们前进的过程中，我们将继续开发精简的 过程和资源，以促进研究过程和援助合作;制定和准备一个 翻译科学的劳动力是多学科的，在团队科学舒适;使用创新 信息学解决方案，以推进转化研究;并拥有随时可部署的系统，以快速响应 创新的、合作的项目。我们将通过以下全球具体目标实现我们的目标： 1)培养一支熟练和多样化的翻译队伍，以进行多学科团队科学和推进 发现的翻译; 2）使广泛的利益相关者参与临床转化研究，包括 患者、社区领导人、卫生保健提供者和临床医生、行业和政策制定者;以及进一步支持 CTSA中心之间的协作; 3）整合，支持和加速跨学科的临床转化研究 多学科的完整翻译谱和整个生命周期的不同人群; 4） 促进研究和发展进行转化科学的方法和过程， 将促进翻译的进步; 5）支持使用和推进创新的信息学解决方案， 推进转化研究，并帮助培训CTSA员工。这些目标将指导我们的课程， 未来五年，随着我们进一步发展临床和转化企业，为CTSA网络做出贡献， 促进伊利诺伊州人民和国家的健康。

项目成果

Heterogeneous phenotypes of Pten-null hepatocellular carcinoma in hepatitis B virus transgenic mice parallels liver lobule zonal gene expression patterns.

• DOI: 10.1016/j.virol.2021.11.007
• 发表时间: 2022-01
• 期刊: Virology
• 影响因子: 3.7
• 作者: Oropeza CE;Ondracek CR;Tarnow G;Maienschein-Cline M;Green SJ;McLachlan A
• 通讯作者: McLachlan A

Texture analysis of placental MRI: can it aid in the prenatal diagnosis of placenta accreta spectrum?

• DOI: 10.1007/s00261-019-02104-1
• 发表时间: 2019-09-01
• 期刊: ABDOMINAL RADIOLOGY
• 影响因子: 2.4
• 作者: Chen, Eric;Mar, Winnie A.;Cai, Kejia
• 通讯作者: Cai, Kejia

Implementing an Electronic Patient-Reported Outcome and Decision Support Tool in Early Intervention.

• DOI: 10.1055/s-0042-1760631
• 发表时间: 2023-01
• 期刊: APPLIED CLINICAL INFORMATICS
• 影响因子: 2.9
• 作者: Rizk, Sabrin;Kaelin, Vera C.;Sim, Julia Gabrielle C.;Murphy, Natalie J.;McManus, Beth M.;Leland, Natalie E.;Stoffel, Ashley;James, Lesly;Barnekow, Kris;Papautsky, Elizabeth Lerner;Khetani, Mary A.
• 通讯作者: Khetani, Mary A.

The interplay of stress and electrocortical reactivity to reward in the prospective prediction of depression symptoms during COVID-19.

• DOI: 10.1016/j.jpsychires.2021.05.034
• 发表时间: 2021-08
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Feurer C;Granros M;Calentino AE;Suor JH;Patel K;Burkhouse KL
• 通讯作者: Burkhouse KL

Diabetes multimorbidity combinations and disability in the Mexican Health and Aging Study, 2012-2015.

• DOI: 10.1016/j.archger.2020.104292
• 发表时间: 2021-03
• 期刊: Archives of gerontology and geriatrics
• 影响因子: 4
• 作者: McClellan SP;Haque K;García-Peña C
• 通讯作者: García-Peña C