Clinical and Translational Science Award

临床和转化科学奖

• 批准号: 10665627
• 负责人: Robin J. Mermelstein
• 金额: $ 371.04万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665627
• 关键词: Acceleration; Address; Automobile Driving; Basic Science; Chicago; Clinical; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Collaborations; Communities; Community Health; Complex; Data; Data Sources; Development; Discipline; Dissemination and Implementation; Education; Ethnic Origin; Evaluation; Foundations; Funding; Goals; Health; Health Personnel; Health Sciences; Illinois; Individual; Industry; Informatics; Institution; Longevity; Methods; Minority Groups; Mission; Modeling; Movement; Outcome; Patients; Persons; Policies; Policy Maker; Population; Population Heterogeneity; Positioning Attribute; Postdoctoral Fellow; Process; Reproducibility; Research; Resources; Science; Scientist; Site; Special Population; System; Training; Training Programs; Translational Research; Translations; Underserved Population; United States National Institutes of Health; Universities; Vulnerable Populations; Workforce Development; catalyst; clinical center; clinical translation; college; community engaged research; community engagement; graduate student; implementation science; improved; informatics infrastructure; innovation; member; method development; multi-site trial; multidisciplinary; multimodal data; population health; programs; recruit; social health determinants; success; translational barrier; translational pipeline

The University of Illinois at Chicago (UIC) Center for Clinical and Translational Science (CCTS) seeks to catalyze translational research, locally and nationally, as part of a national network to improve individual and population health. Since our initial funding by the NIH in 2009, the CCTS has been a catalyst for mobilizing institutional support and resources to enhance clinical translational research and expand multidisciplinary training programs to increase workforce diversity and promote team science. The overarching goal—and driving focus—of the CCTS is to improve population health, particularly among minorities and underserved populations. Our high- quality multidisciplinary clinical and translational research, spanning T1-T4 and paired with strengths in community engagement and implementation science and appreciation for the social determinants of health, help to accelerate discoveries into practice and policy. Building on our organizational foundation and record of success, the UIC CCTS is well-positioned to make substantial contributions by collaborating with other hubs, supporting national CTSA activities, and making unique contributions to community-engaged research with vulnerable and underserved populations. As we move forward, we will continue to develop streamlined processes and resources to facilitate research processes and aid collaboration; to develop and prepare a translational science workforce that is multidisciplinary and comfortable in team science; to use innovative informatics solutions to advance translational research; and to have ready-to-deploy systems to respond rapidly to innovative, collaborative projects. We will achieve our objectives through the following global specific aims: 1) Develop a skillful and diverse translational workforce to conduct multidisciplinary team science and advance translation of discoveries; 2) Engage a broad range of stakeholders in clinical translational research, including patients, community leaders, health care providers and clinicians, industry and policy makers; and further support collaboration among the CTSA hubs; 3) Integrate, support, and accelerate clinical translational research across the full translational spectrum with multiple disciplines and with diverse populations across the lifespan; 4) Promote advances in study and development of methods and processes of conducting translational science that will enable advances in translation; and 5) Support the use and advance of innovative informatics solutions to advance translational research and to help train the CTSA workforce. These aims will direct our course over the next five years, as we further evolve the clinical and translational enterprise, contribute to the CTSA network, and advance the health of the people of Illinois and the nation.

伊利诺伊大学芝加哥分校 (UIC) 临床和转化科学中心 (CCTS) 致力于促进 地方和国家的转化研究，作为改善个人和人口的国家网络的一部分 健康。自 2009 年 NIH 首次资助以来，CCTS 一直是动员机构的催化剂 支持和资源，以加强临床转化研究并扩大多学科培训计划 增加劳动力多样性并促进团队科学。的总体目标和驱动重点 CCTS 旨在改善人口健康，特别是少数族裔和服务不足人群的健康。我们的高 高质量的多学科临床和转化研究，跨越 T1-T4，并与以下方面的优势相结合 社区参与和实施科学以及对健康的社会决定因素的认识，帮助 加速将发现转化为实践和政策。以我们的组织基础和记录为基础 UIC CCTS 的成功，使其能够通过与其他中心的合作做出重大贡献， 支持国家 CTSA 活动，并为社区参与的研究做出独特贡献 弱势和服务不足的人群。在我们前进的过程中，我们将继续开发精简的 促进研究进程和援助协作的流程和资源；制定并准备一个 多学科且擅长团队科学的转化科学劳动力；使用创新的 推进转化研究的信息学解决方案；并拥有可立即部署的系统以快速响应 创新的协作项目。我们将通过以下全球具体目标来实现我们的目标： 1) 培养一支熟练且多元化的翻译队伍，以进行多学科团队科学和进步 翻译发现； 2) 让广泛的利益相关者参与临床转化研究，包括 患者、社区领袖、医疗保健提供者和临床医生、行业和政策制定者；以及进一步的支持 CTSA 中心之间的协作； 3) 整合、支持和加速跨领域的临床转化研究 跨学科、跨生命周期的不同人群的完整翻译范围； 4） 促进转化科学方法和过程的研究和开发进步， 将促进翻译的进步； 5) 支持创新信息学解决方案的使用和推进 推进转化研究并帮助培训 CTSA 员工队伍。这些目标将指导我们的前进方向 未来五年，随着我们进一步发展临床和转化企业，为 CTSA 网络做出贡献， 促进伊利诺伊州人民和国家的健康。

项目成果

Heterogeneous phenotypes of Pten-null hepatocellular carcinoma in hepatitis B virus transgenic mice parallels liver lobule zonal gene expression patterns.

• DOI: 10.1016/j.virol.2021.11.007
• 发表时间: 2022-01
• 期刊: Virology
• 影响因子: 3.7
• 作者: Oropeza CE;Ondracek CR;Tarnow G;Maienschein-Cline M;Green SJ;McLachlan A
• 通讯作者: McLachlan A

Texture analysis of placental MRI: can it aid in the prenatal diagnosis of placenta accreta spectrum?

• DOI: 10.1007/s00261-019-02104-1
• 发表时间: 2019-09-01
• 期刊: ABDOMINAL RADIOLOGY
• 影响因子: 2.4
• 作者: Chen, Eric;Mar, Winnie A.;Cai, Kejia
• 通讯作者: Cai, Kejia

Implementing an Electronic Patient-Reported Outcome and Decision Support Tool in Early Intervention.

• DOI: 10.1055/s-0042-1760631
• 发表时间: 2023-01
• 期刊: APPLIED CLINICAL INFORMATICS
• 影响因子: 2.9
• 作者: Rizk, Sabrin;Kaelin, Vera C.;Sim, Julia Gabrielle C.;Murphy, Natalie J.;McManus, Beth M.;Leland, Natalie E.;Stoffel, Ashley;James, Lesly;Barnekow, Kris;Papautsky, Elizabeth Lerner;Khetani, Mary A.
• 通讯作者: Khetani, Mary A.

The interplay of stress and electrocortical reactivity to reward in the prospective prediction of depression symptoms during COVID-19.

• DOI: 10.1016/j.jpsychires.2021.05.034
• 发表时间: 2021-08
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Feurer C;Granros M;Calentino AE;Suor JH;Patel K;Burkhouse KL
• 通讯作者: Burkhouse KL

Diabetes multimorbidity combinations and disability in the Mexican Health and Aging Study, 2012-2015.

• DOI: 10.1016/j.archger.2020.104292
• 发表时间: 2021-03
• 期刊: Archives of gerontology and geriatrics
• 影响因子: 4
• 作者: McClellan SP;Haque K;García-Peña C
• 通讯作者: García-Peña C