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Varieties of Impulsivity in Opiate and Stimulant Users

阿片类药物和兴奋剂使用者的各种冲动

基本信息

批准号：
10630305
负责人：
JASMIN L VASSILEVA
金额：
$ 50.26万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10630305
关键词：
Abstinence Address Amphetamine Users Amphetamines Amygdaloid structure Back Balkans Behavioral Biological Models Brain Bulgaria Classification Clinical Clinical assessments Cognitive Collaborations Computing Methodologies Corpus striatum structure Country Data Development Dimensions Emotional Emotions Enrollment Etiology European Executive Dysfunction Face Functional Magnetic Resonance Imaging Genetic Genotype Geography Heroin Heroin Users Heterogeneity Impulsivity Individual Joints Laboratories Learning Length Link Machine Learning Maintenance Mental disorders Modeling Neurobiology Neurocognitive Neurosciences Opiate Addiction Parents Participant Pattern Personality Pharmaceutical Preparations Phase Phenotype Population Positioning Attribute Production Psychometrics Public Health Research Research Domain Criteria Rest Risk Risk Behaviors Risk Factors Route Siblings Stimulant Substance Use Disorder Taxonomy Testing addiction alcohol use disorder biotypes brain based clinical phenotype cohort computer framework emotion dysregulation executive function financial incentive heuristics incentive salience indexing instrument multidisciplinary multimodal data neural circuit neurobehavioral neuroimaging neuropsychiatric disorder opioid use opioid use disorder opioid user personalized intervention pharmacologic polygenic risk score programs reward anticipation segregation stimulant dependence stimulant use stimulant use disorder stimulant user substance user theories therapy development trafficking

项目摘要

Project Summary Impulsivity has gained prominence as one of the cardinal etiological risk factors for the development and maintenance of addictive disorders. However, both impulsivity and addiction are highly heterogeneous, which has hampered progress in understanding the link between the two. To address this heterogeneity, we have developed a program of addiction research in Bulgaria, a major European center for production of synthetic amphetamine-type stimulants and a key transit country for heroin trafficking, due to its strategic geographical position on the Balkan Drug Route. Through our 17-yearlong collaboration with Bulgarian colleagues, we have accessed rare populations of predominantly monosubstance-dependent (‘pure’) heroin and amphetamine users, many in protracted abstinence. In the parent DA021421 study, we have tested >800 participants with a comprehensive assessment battery of clinical, personality, and neurocognitive tasks of impulsivity and related externalizing and internalizing phenotypes. We genotyped participants with the Smokescreen array and enrolled siblings discordant for opiate and stimulant addictions. We combined theory-driven (e.g. cognitive modeling, joint modeling) with data-driven (e.g. machine learning (ML)) computational approaches, which proved particularly informative and revealed distinct multivariate risk profiles characterizing opiate and stimulant addictions with high degree of accuracy. Findings from the parent study significantly informed our integrative multidisciplinary framework (Vassileva & Conrod, 2019), which highlights the potential for distinct dimensions of impulsivity to inform clinical assessment and intervention development for different types of addictions. Impulsivity also figures prominently in the neuroscience-based heuristic framework for the neuroclinical assessment of addictions (ANA; Kwako et al., 2016), which proposes that successful addiction treatment must accommodate the heterogeneity and different etiological mechanisms implicated in addictions, by performing multidimensional assessments focusing on three neurofunctional domains of impulsivity and compulsivity: executive function (EF), incentive salience (IS), and negative emotionality (NE). However, because the ANA framework is based primarily on findings in alcohol use disorder, it is not well understood how these domains might generalize to other SUD, such as opiate and stimulant use disorders. The current competing renewal application aims to address this critical gap with the following specific aims: Aim 1: Identify key personality, neurobehavioral, polygenic, and computational markers of opiate and stimulant addiction following the ANA framework, using the comprehensive assessment battery and computational methods developed in the parent DA021421 with 250 participants (100 with opiate use disorder, 100 with stimulant use disorder, and 50 healthy controls); Aim 2: Identify the brain signatures of the 3 ANA domains (EF, IS, NE) in opiate and stimulant addictions; Exploratory Aim 3: Combine data from Aims 1 and 2 to identify addiction biotypes based on neurocircuitry implicated in the ANA domains.

项目摘要冲动已经成为发展的主要病因风险因素之一，维持成瘾性障碍。然而，冲动和成瘾都是高度异质性的，阻碍了对两者之间联系的理解。为了解决这种异质性，我们在保加利亚开发了一个成瘾研究项目，保加利亚是欧洲主要的合成药物生产中心。由于其战略地理位置，在巴尔干半岛的贩毒路线上的位置通过与保加利亚同事长达17年的合作，我们接触了主要依赖单一物质（“纯”）海洛因和安非他明的少数人群，许多人长期禁欲。在母研究DA 021421中，我们测试了>800名参与者，冲动性和相关的临床、人格和神经认知任务的综合评估组合外化和内化表型。我们用Smokescreen阵列对参与者进行基因分型，因鸦片和兴奋剂成瘾而不和谐的兄弟姐妹。我们结合了理论驱动（例如认知建模，联合建模）与数据驱动（例如机器学习（ML））的计算方法，这证明特别信息丰富，揭示了不同的多变量风险特征，其特征是阿片类药物和兴奋剂成瘾，准确度。来自母研究的发现为我们的综合多学科研究提供了重要信息。框架（Vassileva & Conrod，2019），它强调了冲动的不同维度的潜力，为不同类型的成瘾提供信息的临床评估和干预发展。冲动也是突出地在基于神经科学的启发式框架中用于成瘾的神经临床评估（ANA; Kwako等人，2016），其中提出，成功的成瘾治疗必须适应异质性和不同的病因机制牵连成瘾，通过执行多维评估，专注于冲动和强迫的三个神经功能领域：执行功能（EF），激励显著性（IS）和消极情绪性（NE）。然而，由于ANA框架主要基于在酒精使用障碍中的发现，尚不清楚这些领域如何推广到其他SUD，例如鸦片剂和兴奋剂使用障碍。目前的竞争性续期申请旨在解决这一问题关键的差距，以下具体目标：目标1：确定关键的个性，神经行为，多基因，和阿片类药物和兴奋剂成瘾的计算标记物遵循ANA框架，使用综合在母公司DA 021421中开发的评估组合和计算方法，有250名参与者（100 阿片类药物使用障碍，100例兴奋剂使用障碍，50例健康对照）;目的2：识别大脑阿片类和兴奋剂成瘾中ANA 3个结构域（EF、IS、NE）的特征;探索性目标3：联合收割机来自目的1和2的数据，以基于ANA结构域中涉及的神经回路来鉴定成瘾生物型。

项目成果

期刊论文数量（33）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Outcome-Representation Learning Model: A Novel Reinforcement Learning Model of the Iowa Gambling Task.

DOI：
10.1111/cogs.12688
发表时间：
2018-11
期刊：
Cognitive science
影响因子：
2.5
作者：
Haines N;Vassileva J;Ahn WY
通讯作者：
Ahn WY

Psychopathic heroin addicts are not uniformly impaired across neurocognitive domains of impulsivity.

DOI：
10.1016/j.drugalcdep.2010.09.021
发表时间：
2011-04-01
期刊：
DRUG AND ALCOHOL DEPENDENCE
影响因子：
4.2
作者：
Vassileva, Jasmin;Georgiev, Stefan;Martin, Eileen;Gonzalez, Raul;Segala, Laura
通讯作者：
Segala, Laura

Divergent changes: abstinence and higher-frequency substance use increase among racial/ethnic minority young adults during the COVID-19 global pandemic.

DOI：
10.1080/00952990.2021.1995401
发表时间：
2022-01-02
期刊：
The American journal of drug and alcohol abuse
影响因子：
0
作者：
Hicks TA;Chartier KG;Buckley TD;Reese D;Working Group TSFS;Vassileva J;Dick DM;Amstadter AB;Peterson RE;Moreno O
通讯作者：
Moreno O

Effects of Psychopathy on Neurocognitive Domains of Impulsivity in Abstinent Opiate and Stimulant Users.