Early Life Adversity, Cumulative Life Stress, Race, and Cellular Aging in Midlife Women and Offspring
中年女性和后代的早年逆境、累积生活压力、种族和细胞衰老
基本信息
- 批准号:10017117
- 负责人:
- 金额:$ 57.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-15 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:10 year old20 year oldAddressAdherenceAdolescenceAdultAfrican AmericanAgeAgingAnimalsArchivesBiological AgingBiological MarkersBiology of AgingBloodBuffersC-reactive proteinCardiovascular DiseasesCategoriesCell AgingCellsChildChildhoodChronicChronic DiseaseComplementComplexDataDevelopmentDietDiscriminationDiseaseEnrollmentEnsureEpigenetic ProcessEventExposure toGenerationsGeneticGenetic LoadGenomeGrowthHealthHumanIndividualInflammationLengthLeukocytesLifeLife Cycle StagesLife StressLinkLongevityLongitudinal cohortMeasuresMethylationMinorityModelingNational Heart, Lung, and Blood InstituteNeighborhoodsObesityOnset of illnessParticipantPathway interactionsPerceptionPoliciesPregnancyPremature aging syndromeProcessProspective StudiesPsychological StressPsychosocial StressRaceRegulationRiskRoleSalivaSample SizeSamplingSerumSocial supportSourceStressTestingTimeViolenceVisitWomanage relatedbiracialblack/white disparitycohortcritical perioddeprivationdesigndisorder riskearly life adversityearly life stressearly onsetenvironmental stressorepigenomeepigenomicsfollow-upgirlshealth differencehealth disparityindexingintergenerationalmiddle agenoveloffspringperceived stressprematureprogramsprospectiveprotective effectpsychologicpsychosocialracial differenceracial disparityrecruitresilienceresponsesecondary analysisself esteemsocialsocioeconomic disadvantagesocioeconomic disparitysocioeconomicsstressortelomeretransmission processtraumatic event
项目摘要
Early Life Adversity, Cumulative Stress, Race, & Cell Aging in Midlife Women & Offspring
BACKGROUND: There is an increasingly recognized role of stress in elevating disease risk, especially among
women, minorities and socioeconomically disadvantaged groups. Few prospective studies follow individuals
from childhood to adulthood, leaving critical unanswered questions such as which types of adversity, and life
periods (childhood, adolescence, adulthood, or cumulative) have the greatest impact on biological aging and
can help explain racial differences in health. We have a remarkable opportunity to examine types of lifespan
stress in a longitudinal cohort of black and white women who have been followed from 10 years old. We have
collected multiple sources of stress, including individual stressors (severe life events, chronic stressors, global
perceived stress) and environmental stressors (neighborhood deprivation and violence). Our broad aim is to
conduct a novel examination of adversity and links to current epigenomic markers (telomere length,
epigenetic aging) in women and their children, and to systemic inflammation in the women. In this re-
submission, we have identified archived serum samples from the womens’ childhood baseline visit and are
thus able to examine change in inflammation as well. These indices of biological aging each serve as a reliable
predictor of early disease.
METHOD: We are conducting a 30 year follow up of the prospective NHLBI Growth and Health Study (NGHS),
a biracial cohort of children to examine intergenerational transmission of obesity (R01 HD073568). Black and
white girls were initially followed prospectively from 10 to 20 years old and are now being enrolled at roughly
39 years old. Here we propose to assess indices of cellular aging in 590 NGHS women and their most recent
(index) child. Retention of sample and adherence to blood and saliva sampling are excellent and an R56
helped us ensure our target sample size. We will assess whether lifespan stress is associated with indices
of accelerated cellular aging at age 39, and for inflammation, change from childhood (Aim 1) and secondarily
whether types of stress (severe events, chronic stressors, global perceptions, neighborhood deprivation) or
time-periods (childhood, adolescence, adulthood) have differential or cumulative effects. We will assess
whether pregnancy stress or lifespan stress is associated with offspring epigenomic markers (Aim 2), and
whether race modifies these effects (Aim 3). Lastly, we will explore whether high resilience (support and self-
esteem) buffers the effects of adversity.
SIGNIFICANCE & INNOVATION: This will be the first prospective study to test lifespan stress predictors of
three distinct indices of biological aging, each representing different pathways of aging, in a biracial cohort and
to assess stress effects on offspring epigenome. This should advance our understanding of lifespan stress on
aging biology. A more granular understanding of the types and timing of stress that impact aging processes is
necessary for designing policies and programs that reduce socioeconomic disparities in health and aging.
中年妇女及其后代的早期逆境、累积压力、种族与细胞老化
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elissa S. Epel其他文献
Examining the association of vaccine-related mindsets and post-vaccination antibody response, side effects, and affective outcomes
- DOI:
10.1016/j.bbih.2024.100818 - 发表时间:
2024-10-01 - 期刊:
- 影响因子:
- 作者:
Darwin A. Guevarra;Ethan G. Dutcher;Alia J. Crum;Aric A. Prather;Elissa S. Epel - 通讯作者:
Elissa S. Epel
The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress
- DOI:
10.1038/s41598-024-77279-9 - 发表时间:
2024-12-30 - 期刊:
- 影响因子:3.900
- 作者:
Mauricio Guillen-Parra;Jue Lin;Aric A. Prather;Owen M. Wolkowitz;Martin Picard;Elissa S. Epel - 通讯作者:
Elissa S. Epel
A randomized controlled clinical trial of a Wim Hof Method intervention in women with high depressive symptoms
- DOI:
10.1016/j.cpnec.2024.100272 - 发表时间:
2024-11-01 - 期刊:
- 影响因子:
- 作者:
Robin Blades;Wendy Berry Mendes;Brian P. Don;Stefanie E. Mayer;Rebecca Dileo;Julia O'Bryan;Elena Fromer;Joanna Y. Guan;Sylvia S. Cheng;Ashley E. Mason;Aric A. Prather;Elissa S. Epel - 通讯作者:
Elissa S. Epel
Correction to: Asymmetrical Effects of Sleep and Emotions in Daily Life
- DOI:
10.1007/s42761-022-00120-x - 发表时间:
2022-05-04 - 期刊:
- 影响因子:2.600
- 作者:
David B. Newman;Elissa S. Epel;Michael Coccia;Eli Puterman;Aric A. Prather - 通讯作者:
Aric A. Prather
Psychological and metabolic stress: A recipe for accelerated cellular aging?
- DOI:
10.14310/horm.2002.1217 - 发表时间:
2009-01-01 - 期刊:
- 影响因子:2.500
- 作者:
Elissa S. Epel - 通讯作者:
Elissa S. Epel
Elissa S. Epel的其他文献
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{{ truncateString('Elissa S. Epel', 18)}}的其他基金
Multi-Level Trial of a Workplace Sales Ban of Sugary Beverages and Brief Motivational Counseling Intervention on Adiposity
工作场所销售含糖饮料禁令的多层次试验和肥胖的简短动机咨询干预
- 批准号:
10467924 - 财政年份:2022
- 资助金额:
$ 57.53万 - 项目类别:
A workplace multilevel intervention to reduce sugary beverage intake: Can the Compulsive Eating Phenotype guide better treatment matching, and does it work through predicted mechanisms of action?
减少含糖饮料摄入量的工作场所多层次干预:强迫性饮食表型能否指导更好的治疗匹配,是否通过预测的作用机制发挥作用?
- 批准号:
10666314 - 财政年份:2022
- 资助金额:
$ 57.53万 - 项目类别:
Multi-Level Trial of a Workplace Sales Ban of Sugary Beverages and Brief Motivational Counseling Intervention on Adiposity
工作场所销售含糖饮料禁令的多层次试验和肥胖的简短动机咨询干预
- 批准号:
10609047 - 财政年份:2022
- 资助金额:
$ 57.53万 - 项目类别:
Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-Being
促进社会心理
- 批准号:
10772764 - 财政年份:2021
- 资助金额:
$ 57.53万 - 项目类别:
Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-Being
促进社会心理
- 批准号:
10170641 - 财政年份:2021
- 资助金额:
$ 57.53万 - 项目类别:
Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-Being
促进社会心理
- 批准号:
10581690 - 财政年份:2021
- 资助金额:
$ 57.53万 - 项目类别:
Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-Being
促进社会心理
- 批准号:
10652196 - 财政年份:2021
- 资助金额:
$ 57.53万 - 项目类别:
Early Life Adversity, Cumulative Life Stress, Race, and Cellular Aging in Midlife Women and Offspring
中年女性和后代的早年逆境、累积生活压力、种族和细胞衰老
- 批准号:
10180837 - 财政年份:2019
- 资助金额:
$ 57.53万 - 项目类别:
Early Life Adversity, Cumulative Life Stress, Race, and Cellular Aging in Midlife Women and Offspring
中年女性和后代的早年逆境、累积生活压力、种族和细胞衰老
- 批准号:
10390237 - 财政年份:2019
- 资助金额:
$ 57.53万 - 项目类别:
Optimizing lifestyle interventions with mindfulness-based strategies in type 2 diabetes
利用基于正念的策略优化 2 型糖尿病的生活方式干预
- 批准号:
9206912 - 财政年份:2016
- 资助金额:
$ 57.53万 - 项目类别:
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