Longitudinal study of sleep deficiency mechanisms among Filipino migrants

菲律宾移民睡眠不足机制的纵向研究

• 批准号: 10667376
• 负责人: Gilbert Gee
• 金额: $ 72.8万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-23 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10667376
• 关键词: Accidental Injury; Acculturation; Adult; Affect; African American population; Alaska; American; Area; Asian Americans; Asian population; Belief; Biological Markers; Blood; Buffers; Cardiometabolic Disease; Centers for Disease Control and Prevention (U.S.); Circadian Dysregulation; Circadian Rhythms; Cities; Custom; Data; Data Collection; Diabetes Mellitus; Diet; Discrimination; Disparity; Disparity population; Dryness; Economics; Emigrant; Environment; Ethnic Origin; Filipino; Filipino American; Health; Healthy People 2020; Heart Diseases; Heterogeneity; High Prevalence; Immigrant; Insulin Resistance; Intervention Studies; Interview; Learning; Light; Longitudinal Studies; Measures; Mediating; Mediator; Migrant; Minority Groups; National Health Interview Survey; Noise; Obesity; Occupational; Participant; Patient Self-Report; Personal Satisfaction; Persons; Philippines; Physical activity; Play; Population; Public Health; Qualitative Research; Reporting; Research; Resources; Risk; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Social support; Spottings; Stimulus; Stress; Subgroup; Sunlight; Texas; Time; Translational Research; Travel; United States National Institutes of Health; Variant; actigraphy; biopsychosocial; disparity reduction; environmental stressor; health goals; high risk; improved; informant; insight; longitudinal design; mortality; novel; occupational stressor; poor sleep; psychosocial; psychosocial stressors; residence; rumination; shift work; sleep onset; sleep pattern; sleep quality; social capital; stressor

ABSTRACT Sleep deficiency is a major public health concern. The Centers for Disease Control and Prevention shows that about 20% of American adults have insufficient sleep. Short sleep duration and irregular sleep timing is related to increased risk for health problems ranging from obesity to diabetes to earlier mortality, as well as other problems such increased unintentional injuries and decreased ability to concentrate. Per Healthy People 2020, understanding the burden sleep deficiencies among minority populations is an important public health goal. Filipino Americans are a significant population from which to study sleep because they have relatively high rates of diabetes, obesity, and heart disease, and preliminary studies have suggested that they also have shorter sleep duration compared with African Americans and Whites. A major unanswered question relates to the mechanisms that may drive shorter sleep duration and irregular sleep timing. We hypothesize that stress plays a key role, and that several important mechanisms mediate the association between stressors and sleep disparities. These mechanisms include rumination, diet, physical activity, disrupted routines, and environmental stimuli, such as noise and light. The present study builds on an ongoing 3-year longitudinal study of Filipino American immigrants titled, Health of Philippine Emigrants Study (HoPES; R01HD083574). HoPES is currently in its first year and collects detailed information regarding stressors, diet, physical activity, anthropometrics and biomarkers obtained from dried blood spots. This application seeks to add objective measures of sleep activity via actigraphy, and comprehensive sleep quality questions. We will also study the effects of sunlight variability as another mechanism that may disrupt circadian rhythms. Our study will integrate a biopsychosocial framework from which to longitudinally study sleep patterns of Filipinos (n=832) across the U.S. over 4 years of new data collection. We will also conduct key-informant interviews and re-interviews with 60 participants in 6 cities across the nation to understand the cultural mechanisms that may affect sleep disturbances.

抽象的 睡眠不足是一个主要的公共卫生问题。美国疾病控制与预防中心显示， 大约20%的美国成年人睡眠不足。睡眠时间短与睡眠时间不规律有关 增加健康问题的风险，从肥胖到糖尿病，再到过早死亡，以及其他 诸如意外伤害增加和注意力集中能力下降等问题。根据《健康人 2020》， 了解少数群体睡眠不足的负担是一项重要的公共卫生目标。 菲律宾裔美国人是研究睡眠的重要人群，因为他们的睡眠质量相对较高 糖尿病、肥胖症和心脏病的发病率，初步研究表明，他们也有 与非裔美国人和白人相比，睡眠时间较短。 一个尚未解答的主要问题涉及可能导致睡眠时间缩短和不规律的机制。 睡眠时间。我们假设压力起着关键作用，并且有几个重要机制介导 压力源与睡眠差异之间的关联。这些机制包括反刍、饮食、身体 活动、扰乱的日常生活以及环境刺激，例如噪音和光线。 本研究建立在一项针对菲律宾裔美国移民的为期 3 年的纵向研究的基础上，该研究题为“健康” 菲律宾移民研究（HoPES；R01HD083574）。 HoPES 目前处于第一年并收集 有关压力源、饮食、体力活动、人体测量学和生物标志物的详细信息 干血斑。该应用程序旨在通过体动记录仪添加睡眠活动的客观测量，以及 全面的睡眠质量问题。我们还将研究阳光变化的影响作为另一个 可能扰乱昼夜节律的机制。我们的研究将整合生物心理社会框架 纵向研究美国菲律宾人 (n=832) 超过 4 年的新数据的睡眠模式 收藏。我们还将对6个城市的60名参与者进行关键信息访谈和重新访谈 全国范围内了解可能影响睡眠障碍的文化机制。