Longitudinal study of sleep deficiency mechanisms among Filipino migrants

摘要 睡眠不足是一个主要的公共健康问题。疾病控制和预防中心的数据显示， 大约20%的美国成年人睡眠不足。睡眠时间短与睡眠时间不规律有关 增加健康问题的风险，从肥胖到糖尿病，再到过早死亡，以及其他 诸如意外伤害增加和注意力集中能力下降等问题。每健康人2020年， 了解少数民族睡眠不足的负担是一个重要的公共卫生目标。 菲律宾裔美国人是研究睡眠的重要人群，因为他们的睡眠质量相对较高， 糖尿病、肥胖和心脏病的发病率，初步研究表明， 与非洲裔美国人和白人相比，睡眠时间更短。 一个主要的未回答的问题涉及可能导致睡眠时间缩短和不规律的机制。 睡眠时间我们假设压力起着关键作用，并且有几种重要的机制介导了这种变化。 压力源和睡眠差异之间的关系。这些机制包括反刍，饮食，身体 活动，中断的日常生活和环境刺激，如噪音和光线。 本研究建立在一个正在进行的3年纵向研究菲律宾裔美国移民题为，健康 菲律宾移民研究（HoPES; R 01 HD 083574）。HoPES目前处于第一年，收集 关于压力源、饮食、体力活动、人体测量学和生物标志物的详细信息， 干涸的血迹该申请试图通过体动记录仪增加睡眠活动的客观测量， 全面的睡眠质量问题我们还将研究阳光变化的影响， 可能会扰乱昼夜节律的机制。我们的研究将整合一个生物心理社会框架， 该研究纵向研究了美国各地菲律宾人（n=832）的睡眠模式，超过4年的新数据 收藏.我们还将对6个城市的60名参与者进行关键线人访谈和重新访谈 了解可能影响睡眠障碍的文化机制。

ABSTRACT Sleep deficiency is a major public health concern. The Centers for Disease Control and Prevention shows that about 20% of American adults have insufficient sleep. Short sleep duration and irregular sleep timing is related to increased risk for health problems ranging from obesity to diabetes to earlier mortality, as well as other problems such increased unintentional injuries and decreased ability to concentrate. Per Healthy People 2020, understanding the burden sleep deficiencies among minority populations is an important public health goal. Filipino Americans are a significant population from which to study sleep because they have relatively high rates of diabetes, obesity, and heart disease, and preliminary studies have suggested that they also have shorter sleep duration compared with African Americans and Whites. A major unanswered question relates to the mechanisms that may drive shorter sleep duration and irregular sleep timing. We hypothesize that stress plays a key role, and that several important mechanisms mediate the association between stressors and sleep disparities. These mechanisms include rumination, diet, physical activity, disrupted routines, and environmental stimuli, such as noise and light. The present study builds on an ongoing 3-year longitudinal study of Filipino American immigrants titled, Health of Philippine Emigrants Study (HoPES; R01HD083574). HoPES is currently in its first year and collects detailed information regarding stressors, diet, physical activity, anthropometrics and biomarkers obtained from dried blood spots. This application seeks to add objective measures of sleep activity via actigraphy, and comprehensive sleep quality questions. We will also study the effects of sunlight variability as another mechanism that may disrupt circadian rhythms. Our study will integrate a biopsychosocial framework from which to longitudinally study sleep patterns of Filipinos (n=832) across the U.S. over 4 years of new data collection. We will also conduct key-informant interviews and re-interviews with 60 participants in 6 cities across the nation to understand the cultural mechanisms that may affect sleep disturbances.