Longitudinal study of sleep deficiency mechanisms among Filipino migrants

菲律宾移民睡眠不足机制的纵向研究

• 批准号: 10418716
• 负责人: Gilbert Gee
• 金额: $ 27.1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-23 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10418716
• 关键词: Accidental Injury; Acculturation; Adult; Affect; African American population; Alaska; American; Area; Asian Americans; Asian population; Belief; Biological Markers; Blood; Buffers; Cardiometabolic Disease; Centers for Disease Control and Prevention (U.S.); Circadian Rhythms; Cities; Custom; Data; Data Collection; Diabetes Mellitus; Diet; Discrimination; Economics; Emigrant; Environment; Filipino; Filipino American; Health; Healthy People 2020; Heart Diseases; Heterogeneity; High Prevalence; Immigrant; Insulin Resistance; Intervention Studies; Interview; Lead; Learning; Light; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; Migrant; Minority Groups; National Health Interview Survey; Noise; Obesity; Occupational; Participant; Patient Self-Report; Personal Satisfaction; Persons; Philippines; Physical activity; Play; Population; Public Health; Qualitative Research; Reporting; Research; Resources; Risk; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Social support; Spottings; Stimulus; Stress; Subgroup; Sunlight; Texas; Time; Translational Research; Travel; United States National Institutes of Health; Variant; actigraphy; biopsychosocial; disparity reduction; environmental stressor; health goals; high risk; improved; informant; insight; longitudinal design; mortality; novel; occupational stressor; poor sleep; psychosocial; psychosocial stressors; residence; rumination; shift work; sleep onset; sleep pattern; sleep quality; social capital; stressor

ABSTRACT Sleep deficiency is a major public health concern. The Centers for Disease Control and Prevention shows that about 20% of American adults have insufficient sleep. Short sleep duration and irregular sleep timing is related to increased risk for health problems ranging from obesity to diabetes to earlier mortality, as well as other problems such increased unintentional injuries and decreased ability to concentrate. Per Healthy People 2020, understanding the burden sleep deficiencies among minority populations is an important public health goal. Filipino Americans are a significant population from which to study sleep because they have relatively high rates of diabetes, obesity, and heart disease, and preliminary studies have suggested that they also have shorter sleep duration compared with African Americans and Whites. A major unanswered question relates to the mechanisms that may drive shorter sleep duration and irregular sleep timing. We hypothesize that stress plays a key role, and that several important mechanisms mediate the association between stressors and sleep disparities. These mechanisms include rumination, diet, physical activity, disrupted routines, and environmental stimuli, such as noise and light. The present study builds on an ongoing 3-year longitudinal study of Filipino American immigrants titled, Health of Philippine Emigrants Study (HoPES; R01HD083574). HoPES is currently in its first year and collects detailed information regarding stressors, diet, physical activity, anthropometrics and biomarkers obtained from dried blood spots. This application seeks to add objective measures of sleep activity via actigraphy, and comprehensive sleep quality questions. We will also study the effects of sunlight variability as another mechanism that may disrupt circadian rhythms. Our study will integrate a biopsychosocial framework from which to longitudinally study sleep patterns of Filipinos (n=832) across the U.S. over 4 years of new data collection. We will also conduct key-informant interviews and re-interviews with 60 participants in 6 cities across the nation to understand the cultural mechanisms that may affect sleep disturbances.

摘要 睡眠不足是一个主要的公共卫生问题。疾病控制和预防中心显示， 大约20%的美国成年人睡眠不足。睡眠时间短与睡眠时间不规律有关 增加健康问题的风险，包括肥胖、糖尿病、早期死亡以及其他 这样的问题增加了意外伤害，降低了注意力。每个健康人2020年， 了解少数民族人群中睡眠不足的负担是一个重要的公共卫生目标。 菲律宾裔美国人是研究睡眠的一个重要群体，因为他们的睡眠比例相对较高 糖尿病、肥胖症和心脏病的发病率，初步研究表明，他们还 与非裔美国人和白人相比，他们的睡眠时间更短。 一个主要的悬而未决的问题与可能导致睡眠时间缩短和睡眠不规律的机制有关 睡眠时间。我们假设压力发挥了关键作用，并且有几种重要的机制调节了 压力源和睡眠差距之间的关系。这些机制包括沉思、饮食、身体活动。 活动，被打乱的日常生活，以及环境刺激，如噪音和光线。 这项研究建立在对菲律宾裔美国移民正在进行的一项为期3年的纵向研究的基础上，该研究的标题是，健康 菲律宾移民研究(HOPE；R01HD083574)。Hope目前处于第一年，并收集了 有关应激源、饮食、体力活动、人体测量学和生物标志物的详细信息，可从 干涸的血迹。这个应用程序寻求通过动作图添加睡眠活动的客观测量，并且 全面的睡眠质量问题。我们还将研究日照变化的影响，作为另一种 可能扰乱昼夜节律的机制。我们的研究将整合生物心理社会框架 在四年的新数据中，纵向研究美国各地菲律宾人(n=832)的睡眠模式 收集。我们还将对6个城市的60名参与者进行关键线人访谈和重新访谈 了解可能影响睡眠障碍的文化机制。