Stanford Diabetes Research Center

中心概述：项目摘要/摘要 斯坦福糖尿病研究中心(SDRC)体现了斯坦福大学的一项战略计划的高潮 大学医学院创建一流的项目建立在一流、合作的基础上 研究糖尿病研究中的基础、临床和翻译问题的研究人员。发改委的使命是 促进糖尿病相关研究的创新、新知识和培训，从而改善诊断， 治疗，并最终预防和治愈糖尿病及其并发症。续期本第30页 应用程序将利用斯坦福大学的糖尿病研究，提供致力于 支持以糖尿病为重点的调查和充实活动。斯坦福大学有着深厚的传统 学术卓越、创新和临床护理，在一所真正的大学里结合在一起，促进 来自不同学科的科学家和临床医生之间的互动。斯坦福大学位于硅谷的心脏地带 山谷，一个创新和计算风险承担的中心，其公司与国家发改委的教职员工在 促进糖尿病研究和护理的独特和不断增长的合作。斯坦福大学毗邻两所大学 加州大学伯克利分校和戴维斯分校，这两个精英研究中心的糖尿病研究基础都在不断扩大 未连接至NIDDK DRC。国家发改委由124名成员组成，分别来自斯坦福大学的3所学校和 加州大学伯克利分校和加州大学戴维斯分校的多所学校。斯坦福大学国家发改委成员目前拥有65,044,250美元 糖尿病相关研究的年度直接成本。国家发改委成员由亲和力小组组织，重点是 (I)胰岛与胰腺生物学；(Ii)代谢与信号传递；(Iii)免疫学、移植与干细胞生物学； 以及(Iv)生物工程与行为科学。国家发改委由以下组成：(1)行政部门， 协调科学、组织、充实、培训和外联活动，(2)生物医学研究 招募和挑选成员的组成部分，并监督促进和加强的4个研究核心 他们的研究，以及(3)成功的国家发改委试点和可行性(P&F)奖励计划，以促进 糖尿病研究的早期研究人员，以及对糖尿病研究新手的知名科学家。我们 建议扩展此计划，将支持加州大学戴维斯分校研究的地区P&F计划包括在内 伯克利。国家卫生研究院对国家发改委的支持得到了以下方面的放大：(1)斯坦福大学持续致力于提供空间和 大量财政资源，(2)一系列全面的机构研究核心，使NIDDK 支持国家发改委致力于糖尿病研究的专业研究中心的资金，(3)与 其他斯坦福大学研究中心，以及(4)国家发改委成员领导备受瞩目的国家糖尿病研究 努力。自2017年开始提供P30资金以来，发改委发生了变化，包括其调查人员基础的增长， 更加注重翻译研究，并修改核心服务，以提供不可或缺的支持 用于糖尿病研究。从多方面来看，发改委是创新的力量倍增器，其成员创造了 与基础和转化性糖尿病、肥胖和代谢研究相关的开创性科学贡献。

CENTER OVERVIEW: PROJECT SUMMARY/ABSTRACT The Stanford Diabetes Research Center (SDRC) embodies the culmination of a strategic plan by the Stanford University School of Medicine to create a premier program founded on a base of superb, collaborative investigators studying basic, clinical and translational problems in diabetes research. The SDRC mission is to foster innovation, new knowledge, and training in diabetes-related research, leading to improved diagnosis, treatment, and ultimately, prevention and cure of diabetes and its complications. Renewal of this P30 application will leverage diabetes research at Stanford University by providing crucial resources dedicated to supporting investigations and enrichment activities focused on diabetes. Stanford has a strong tradition of academic excellence, innovation, and clinical care, united in a true University on a single campus that fosters interactions between scientists and clinicians from different disciplines. Stanford is in the heart of Silicon Valley, an epicenter of innovation and calculated risk-taking, whose companies partner with SDRC faculty in unique and growing collaborations to advance diabetes research and care. Stanford neighbors two Universities of California (UC) at Berkeley, and at Davis, both elite research centers with a growing diabetes research base unconnected to a NIDDK DRC. The SDRC is comprised of 124 members from 3 Schools at Stanford, and from multiple Schools at UC Berkeley and UC Davis. SDRC members at Stanford currently have $65,044,250 in annual direct costs for diabetes-related research. SDRC members are organized by affinity groups focused on (i) Islet & Pancreas Biology, (ii) Metabolism & Signaling, (iii) Immunology, Transplantation & Stem Cell Biology, and (iv) Bioengineering & Behavioral Sciences. The SDRC consists of: (1) Administrative Component that coordinates scientific, organizational, enrichment, training and outreach activities, (2) Biomedical Research Component that recruits and selects members, and supervises 4 Research Cores that facilitate and enhance their research, and (3) a successful SDRC Pilot and Feasibility (P&F) Award Program that promotes the diabetes research of early stage investigators, and established scientists new to diabetes research. We propose to expand this Program to include a Regional P&F Program that supports research at UC Davis and Berkeley. NIH support for the SDRC is amplified by (1) Stanford’s sustained commitment to provide space and significant financial resources, (2) a comprehensive array of institutional research cores, which allow NIDDK funds to support specialized SDRC research cores devoted to diabetes research, (3) collaborative efforts with other Stanford research centers, and (4) SDRC member leadership of high-profile national diabetes research efforts. Since P30 funding began in 2017, the SDRC has evolved, including growth of its investigator base, intensified focus on translational research, and modification of core services to provide indispensable support for diabetes research. By multiple metrics, the SDRC is a force multiplier of innovation, whose members make seminal scientific contributions related to basic and translational diabetes, obesity, and metabolism research.