Islet Procurement and Research Core
Islet Procurement and Research Core
批准号:
10197904
负责人:
Seung K Kim
金额:
$17.28万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-15 至 2022-06-30
关键词:
AbbreviationsAgingAmericanAreaBeta CellBiological AssayBiologyBlood VesselsCardiovascular systemCell physiologyCellsCellular biologyChild HealthClinicalClinics and HospitalsCommunitiesComplexCoupledDiabetes MellitusDigestive System DisordersEnsureEnzyme-Linked Immunosorbent AssayEpigenetic ProcessEuropeanEvolutionFunctional disorderGene Expression RegulationGeneticGenomeGenomicsGlucagonGrowthHealthcareHumanHuman ResourcesImmuneImmunologic MonitoringImmunologyInstitutesInsulinInsulin-Dependent Diabetes MellitusInvestigationIslet CellIslets of LangerhansIslets of Langerhans TransplantationLettersMaintenanceMethodsModelingModernizationMolecularMusNamesNatural regenerationNon-Insulin-Dependent Diabetes MellitusOrganPathologicPerfusionPhenotypePhysiologicalPublishingResearchResearch InstituteResearch PersonnelResourcesRodentScienceServicesSignal TransductionTrainingTransplantationUniversitiesWorkbaseendocrine pancreas developmentfallshuman tissueinsulin secretioninvestigator trainingisletmedical schoolsnovelnovel strategiesprogramssuccesstranslational study
中文摘要
项目概要/摘要(胰岛核心)
胰岛采购和研究核心(IPRC)的专业胰岛生物学知识将为SDRC提供
具有进行高质量的现代分子,细胞和功能研究的能力的研究人员
从啮齿动物和人类的胰岛和胰腺。SDRC的大型合作调查小组研究了一个
生理或病理环境中的广谱胰岛生物学,包括胰岛发育、功能
成熟,成熟细胞命运的维持,增殖,遗传学,表观遗传学,基因调控,器官间
信号传导、胰岛细胞内信号转导、胰岛免疫学和衰老,仅举几例。的一个核心方面
IPRC是我们直接关注啮齿动物和人体组织平行研究。一个重要组成部分
支持大多数属于这种范式的研究是我们能够分离出高质量的,良好的,
表征啮齿类动物胰岛,然后进行胰岛细胞、分子和生理的测定,
表型这与IPRC中可靠,强大的程序相结合,以获得高质量的人类胰岛
这增加了SDRC研究人类胰岛生物学的研究人员的数量。的支持
IPRC对人类胰岛细胞功能、生长和命运的基于移植的研究也将提高
人类胰岛对糖尿病的潜在转化研究。除了这些服务外,IPRC还致力于
培养胰岛生物学专门方法的研究人员,如胰岛分离和移植,胰岛
培养和专门的测定,包括胰岛素ELISA、胰高血糖素ELISA、灌注和静态批次胰岛素
分泌测定和免疫组织学。IPRC人员将与SDRC调查人员密切合作,
为他们的目标量身定制的有效实验策略。IPRC还为斯坦福大学社区提供服务,
通过不断开发新的实验能力来满足动态需求,
现代小岛研究的一部分这包括胰岛功能的测定,研究人类胰岛功能的新方法,
细胞遗传学,胰岛移植的新模型,并协助开发新的临床胰岛计划,
斯坦福大学医疗保健的医院和诊所。IPRC还加强了其他研究核心的使用,
斯坦福大学DRC。与糖尿病免疫监测核心(DIMC)和糖尿病基因组学和
分析核心(DGAC),IPRC将整合努力,允许细胞,遗传,分子,生理和
与糖尿病相关的人类胰腺和胰岛相关细胞的基因组研究,包括免疫、间质
和血管细胞。总之,胰岛采购和研究核心将作为一个宝贵的,新颖的,
SDRC的资源,为研究者提供胰腺和胰岛特异性专业知识和培训,
促进并扩大他们的糖尿病相关研究。
英文摘要
Project Summary / Abstract (Islet Core)
The specialized islet biology expertise of the Islet Procurement and Research Core (IPRC) will provide SDRC
investigators with the capacity to perform modern molecular, cellular and functional studies of high-quality
islets and pancreata from rodents and humans. The SDRC's large group of collaborative investigators study a
broad spectrum of islet biology in physiological or pathological settings, including islet development, functional
maturation, maintenance of mature cell fate, proliferation, genetics, epigenetics, gene regulation, inter-organ
signaling, intra-islet cell signal transduction, islet immunology, and aging, to name a few. A central aspect of
the IPRC is our direct focus on parallel studies in rodent and human tissues. An essential component
supporting the majority of studies falling under this paradigm is our ability to isolate high-quality, well-
characterized rodent pancreatic islets, and then to perform assays of islet cellular, molecular and physiological
phenotypes. This is coupled with a reliable, robust programs in the IPRC to procure high-quality human islets
that have increased the number of SDRC investigators studying human islet biology. The support of
transplantation-based studies of human islet cell function, growth and fate by the IPRC will also enhance
potential translational studies of human islets for diabetes. In addition to these services, the IPRC is committed
to training investigators in specialized methods of islet biology, like islet isolation and transplantation, islet
culture and specialized assays including insulin ELISA, glucagon ELISA, perfusion and static batch insulin
secretion assays, and immunohistology. IPRC personnel will work closely with SDRC investigators to build
efficient experimental strategies tailored to their aims. The IPRC also serves the Stanford community of
science and the SDRC by continuously developing new experimental capacity to match the dynamic demands
of modern islet investigations. This includes assays of islet function, new approaches to investigate human islet
cell genetics, new models of islet transplantation, and assistance in developing new clinical islet programs at
the hospitals and clinics of Stanford Health Care. The IPRC also enhances the use of other Research Cores in
the Stanford DRC. Together with the Diabetes Immune Monitoring Core (DIMC) and the Diabetes Genomics &
Analysis Core (DGAC), the IPRC will integrate efforts permitting cellular, genetic, molecular, physiological and
genome studies of human pancreas- and islet-associated cells relevant to diabetes, including immune, stromal
and vascular cells. In summary, the Islet Procurement and Research Core will serve as an invaluable, novel
resource for the SDRC, providing investigators with the pancreas- and islet-specific expertise and training to
enable and expand their diabetes-related research.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Administrative and Biostatistics Core
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批准号:10187128
-
项目类别:
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资助金额:$19.1万
-
财政年份:2021
-
负责人:Seung K Kim
-
依托单位:
Administrative and Biostatistics Core
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批准号:10704093
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项目类别:
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资助金额:$18.17万
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财政年份:2021
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负责人:Seung K Kim
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依托单位:
Core C: CODEX Core
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批准号:10704098
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项目类别:
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资助金额:$33.36万
-
财政年份:2021
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负责人:Seung K Kim
-
依托单位:
Core C: CODEX Core
-
批准号:10456775
-
项目类别:
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资助金额:$33.36万
-
财政年份:2021
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负责人:Seung K Kim
-
依托单位:
Administrative and Biostatistics Core
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批准号:10456772
-
项目类别:
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资助金额:$18.17万
-
财政年份:2021
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负责人:Seung K Kim
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依托单位:
In vivo systems to discover mechanisms regulating human islet alpha cell function
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批准号:10623306
-
项目类别:
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资助金额:$53.89万
-
财政年份:2020
-
负责人:Seung K Kim
-
依托单位:
In vivo systems to discover mechanisms regulating human islet alpha cell function
-
批准号:10228762
-
项目类别:
-
资助金额:$53.9万
-
财政年份:2020
-
负责人:Seung K Kim
-
依托单位:
In vivo systems to discover mechanisms regulating human islet alpha cell function
-
批准号:10441477
-
项目类别:
-
资助金额:$53.89万
-
财政年份:2020
-
负责人:Seung K Kim
-
依托单位:
Therapeutic targeting of human islets with recombinant regulatory T cells
-
批准号:10018894
-
项目类别:
-
资助金额:$73.56万
-
财政年份:2019
-
负责人:Seung K Kim
-
依托单位:
Therapeutic targeting of human islets with recombinant regulatory T cells
-
批准号:10450831
-
项目类别:
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资助金额:$70.99万
-
财政年份:2019
-
负责人:Seung K Kim
-
依托单位:
Therapeutic targeting of human islets with recombinant regulatory T cells
-
批准号:9891726
-
项目类别:
-
资助金额:$76.3万
-
财政年份:2019
-
负责人:Seung K Kim
-
依托单位:
Therapeutic targeting of human islets with recombinant regulatory T cells
-
批准号:10238842
-
项目类别:
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资助金额:$72.29万
-
财政年份:2019
-
负责人:Seung K Kim
-
依托单位:
Discovering genetic and hormonal mechanisms underlying diabetes risk from flies to humans
-
批准号:10376197
-
项目类别:
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资助金额:$39.5万
-
财政年份:2018
-
负责人:Seung K Kim
-
依托单位:
Discovering genetic and hormonal mechanisms underlying diabetes risk from flies to humans
-
批准号:9883793
-
项目类别:
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资助金额:$39.51万
-
财政年份:2018
-
负责人:Seung K Kim
-
依托单位:
Administrative Core
-
批准号:10407862
-
项目类别:
-
资助金额:$37.07万
-
财政年份:2017
-
负责人:Seung K Kim
-
依托单位:
Reconstituting human pancreatic cancer development for translational research
-
批准号:9217005
-
项目类别:
-
资助金额:$51.56万
-
财政年份:2017
-
负责人:Seung K Kim
-
依托单位:
Stanford Diabetes Research Center
-
批准号:10668992
-
项目类别:
-
资助金额:$196.74万
-
财政年份:2017
-
负责人:Seung K Kim
-
依托单位:
Administrative Core
-
批准号:10197903
-
项目类别:
-
资助金额:$18.07万
-
财政年份:2017
-
负责人:Seung K Kim
-
依托单位:
Administrative Core
-
批准号:10668993
-
项目类别:
-
资助金额:$37.07万
-
财政年份:2017
-
负责人:Seung K Kim
-
依托单位:
Stanford Islet Research Core
-
批准号:10407863
-
项目类别:
-
资助金额:$21.5万
-
财政年份:2017
-
负责人:Seung K Kim
-
依托单位:
海外基金