Postdoctoral Training in Cardiovascular Disease

本申请申请第五次竞争性续签博士后培训计划的资金。 心血管疾病。该计划旨在为心脏病和外科专业的学生提供机会 内科医生-科学家培训成为心血管研究的独立研究员。该计划 利用哥伦比亚大学现有的许多优势，包括欧文临床中心 和翻译研究(CTSA)，梅尔曼公共卫生学院，基因组中心，生物信息学，组织 和生物医学工程以及众多的基础科学系和强大的临床项目。我们的 该计划的重点是在培训期间和培训结束后成功完成关键里程碑。钥匙 对于我们的学员来说，里程碑是出版物，特别是第一篇论文，以及金融-和指导- 支持职业发展奖，如K奖，并最终获得R01奖。实习生被曝光 给不同的教职员工，每个人都有充足的资金，有出色的培训和出版记录。实习生是 鼓励选择合作导师，加强他们的多学科培训。教师导师指导研究 四个主要领域的培训：1)血管生物学，包括动脉粥样硬化、糖尿病和新陈代谢；2) 心肌细胞生物学，包括离子通道、药理学和组织与生物医学工程，3) 免疫学和精准医学，以及4)翻译、结果和临床研究。和往常一样 该计划的期限为两年，但可以延长到三年。T32计划建立在高度 以学术为导向的普通外科、心胸外科住院医师和奖学金计划， 和心脏病学。我们的实习生是从大量优秀的临床申请者中挑选出来的 培训计划，以及通过直接申请研究培训计划。特别努力是 为加强我们对妇女和少数群体的招聘而采取的措施。培训计划和核心 科室有完善的心血管研究研讨会系列和期刊俱乐部、联合实验室 旨在促进协作和跨学科研究的会议和务虚会。此外， 培训计划本身主办研讨会和每月进行中的工作会议，以评估受训人员的进步。 培训计划有一个有效的评估和反馈系统，以确保我们的培训适当 伙计们。在整个计划期间和之后，受训人员都会被建议进行研究和职业发展， 个人和通过由培训生发展副主任领导的指导方案。 我们研究培训项目的毕业生继续在成功的学术生涯中前进， 获得顶尖学术研究机构的教员职位，并获得校外同行 审查职业发展奖和研究补助金。总而言之，拟议的计划建立在我们的 25年来成功的临床医生-科学家研究培训记录，利用我们机构的 在临床/转化性和基础心血管研究和教育方面的优势。

This application requests funding for the fifth competitive renewal of a postdoctoral training program in Cardiovascular Diseases. The program is designed to provide opportunities for Cardiology- and Surgical-based physician-scientist trainees to become independent investigators in Cardiovascular research. The program takes advantage of the many existing strengths of Columbia University, including the Irving Center for Clinical and Translational Research (CTSA), Mailman School of Public Health, Genome Center, Bioinformatics, Tissue and Biomedical Engineering and numerous basic science departments and strong clinical programs. Our program focuses on successful completion of critical milestones, during and after the training period. Key milestones for our trainees are publications, especially first-authored papers, and financial- and mentoring- support for career-development awards such as K awards, and ultimately R01 awards. Trainees are exposed to a diverse group of faculty, each well-funded, with outstanding training and publication records. Trainees are encouraged to choose co-mentors, to enhance their multi-disciplinary training. Faculty mentors direct research training in four primary areas: 1) Vascular Biology including atherosclerosis, diabetes and metabolism; 2) Cardiomyocyte biology, including ion channels, pharmacology and tissue- and biomedical-engineering, 3) Immunology and Precision Medicine, and 4) Translational, Outcomes and Clinical Research. The usual duration of the program is two years but may be extended to three years. The T32 program builds on the highly academically-oriented feeder residency and fellowship programs in General Surgery, Cardiothoracic Surgery, and Cardiology. Our trainees are selected from a very large pool of outstanding applicants to these clinical training programs, as well as through direct applications to the research training program. Special efforts are undertaken to enhance our recruitment of women and minorities. The training program and the core departments have well-established cardiovascular research seminar series and journal clubs, joint laboratory meetings and retreats that are designed to foster collaborations and interdisciplinary research. In addition, the training program itself sponsors seminars and monthly work-in-progress sessions to assess trainee progress. The training program has an efficient evaluation and feedback system to ensure appropriate training of our fellows. Throughout the program and afterwards, trainees are advised on research and career development, individually and through a mentoring program headed by an Associate Director for Trainee Development. Graduates of our research training program have continued on the trajectory of successful academic careers, obtaining faculty positions at leading academic research institutions as well as receiving extramural peer reviewed career development awards and research grants. In summary, the proposed program builds upon our 25-year track record of successful research training of clinician-scientists, capitalizing on our institution's strengths in clinical/translational and basic cardiovascular research and education.