Postdoctoral Training in Cardiovascular Disease

心血管疾病博士后培训

• 批准号: 10669045
• 负责人: Marwah Abdalla
• 金额: $ 86.41万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669045
• 关键词: Cardiovascular Diseases; post-doctoral training

This application requests funding for the fifth competitive renewal of a postdoctoral training program in Cardiovascular Diseases. The program is designed to provide opportunities for Cardiology- and Surgical-based physician-scientist trainees to become independent investigators in Cardiovascular research. The program takes advantage of the many existing strengths of Columbia University, including the Irving Center for Clinical and Translational Research (CTSA), Mailman School of Public Health, Genome Center, Bioinformatics, Tissue and Biomedical Engineering and numerous basic science departments and strong clinical programs. Our program focuses on successful completion of critical milestones, during and after the training period. Key milestones for our trainees are publications, especially first-authored papers, and financial- and mentoring- support for career-development awards such as K awards, and ultimately R01 awards. Trainees are exposed to a diverse group of faculty, each well-funded, with outstanding training and publication records. Trainees are encouraged to choose co-mentors, to enhance their multi-disciplinary training. Faculty mentors direct research training in four primary areas: 1) Vascular Biology including atherosclerosis, diabetes and metabolism; 2) Cardiomyocyte biology, including ion channels, pharmacology and tissue- and biomedical-engineering, 3) Immunology and Precision Medicine, and 4) Translational, Outcomes and Clinical Research. The usual duration of the program is two years but may be extended to three years. The T32 program builds on the highly academically-oriented feeder residency and fellowship programs in General Surgery, Cardiothoracic Surgery, and Cardiology. Our trainees are selected from a very large pool of outstanding applicants to these clinical training programs, as well as through direct applications to the research training program. Special efforts are undertaken to enhance our recruitment of women and minorities. The training program and the core departments have well-established cardiovascular research seminar series and journal clubs, joint laboratory meetings and retreats that are designed to foster collaborations and interdisciplinary research. In addition, the training program itself sponsors seminars and monthly work-in-progress sessions to assess trainee progress. The training program has an efficient evaluation and feedback system to ensure appropriate training of our fellows. Throughout the program and afterwards, trainees are advised on research and career development, individually and through a mentoring program headed by an Associate Director for Trainee Development. Graduates of our research training program have continued on the trajectory of successful academic careers, obtaining faculty positions at leading academic research institutions as well as receiving extramural peer reviewed career development awards and research grants. In summary, the proposed program builds upon our 25-year track record of successful research training of clinician-scientists, capitalizing on our institution's strengths in clinical/translational and basic cardiovascular research and education.

本申请要求资助博士后培训计划的第五次竞争性更新， 心血管疾病该计划旨在为心脏病学和外科为基础的 医生-科学家实习生成为心血管研究的独立研究者。程序 充分利用了哥伦比亚大学现有的许多优势，包括欧文临床研究中心， 和转化研究（CTSA）、梅尔曼公共卫生学院、基因组中心、生物信息学、组织 和生物医学工程和众多的基础科学部门和强大的临床计划。我们 该计划的重点是在培训期间和之后成功完成关键里程碑。关键 我们的学员的里程碑是出版物，特别是第一作者的论文，以及财务和指导， 支持职业发展奖，如K奖，并最终R 01奖。学员暴露在 一个多元化的教师群体，每个资金充足，具有出色的培训和出版记录。学员 鼓励选择共同导师，以加强他们的多学科培训。教师指导研究 四个主要领域的培训：1）血管生物学，包括动脉粥样硬化，糖尿病和代谢; 2） 心肌细胞生物学，包括离子通道、药理学和组织及生物医学工程，3） 免疫学和精准医学，以及4）转化，结果和临床研究。通常的 该方案为期两年，但可能延长至三年。T32计划建立在高度 以学术为导向的饲养员住院医师和奖学金计划，在普通外科，心胸外科， 心脏病学我们的学员是从这些临床的优秀申请人中挑选出来的 培训计划，以及通过直接应用到研究培训计划。特别努力 这是为了加强我们对妇女和少数民族的招聘。培训计划和核心 各系拥有完善的心血管研究系列研讨会和期刊俱乐部，联合实验室 旨在促进合作和跨学科研究的会议和务虚会。此外该 培训方案本身赞助研讨会和每月的工作进展会议，以评估受训者的进展。 培训计划有一个有效的评估和反馈系统，以确保我们的员工得到适当的培训。 伙计们在整个项目期间和之后，学员将获得研究和职业发展方面的建议， 个人和通过由实习生发展副总监领导的辅导计划。 我们的研究培训计划的毕业生继续在成功的学术生涯的轨迹， 在领先的学术研究机构获得教职，并接受校外同行 审查了职业发展奖和研究赠款。总而言之，拟议的方案建立在我们的 25-临床医生-科学家的成功研究培训的一年跟踪记录，利用我们机构的 临床/转化和基础心血管研究和教育的优势。

项目成果

Likely damaging de novo variants in congenital diaphragmatic hernia patients are associated with worse clinical outcomes.

先天性diaphragmatragmatic疝患者中可能损害从头变异的变体与临床结果较差有关。

• DOI: 10.1038/s41436-020-0908-0
• 发表时间: 2020-12
• 期刊: Genetics in medicine : official journal of the American College of Medical Genetics
• 作者: Qiao L;Wynn J;Yu L;Hernan R;Zhou X;Duron V;Aspelund G;Farkouh-Karoleski C;Zygumunt A;Krishnan US;Nees S;Khlevner J;Lim FY;Crombleholme T;Cusick R;Azarow K;Danko ME;Chung D;Warner BW;Mychaliska GB;Potoka D;Wagner AJ;Soffer S;Schindel D;McCulley DJ;Shen Y;Chung WK
• 通讯作者: Chung WK

In Vitro Proof of Concept of a First-Generation Growth-Accommodating Heart Valved Conduit for Pediatric Use.

• DOI: 10.1002/mabi.202300011
• 发表时间: 2023-07
• 期刊: Macromolecular bioscience
• 影响因子: 4.6

New developments for the detection and treatment of cardiac vasculopathy.

• DOI: 10.1097/hco.0000000000000388
• 发表时间: 2017-05
• 期刊: Current opinion in cardiology
• 影响因子: 2.3
• 作者: Clerkin KJ;Ali ZA;Mancini DM
• 通讯作者: Mancini DM

Hepatic dysfunction in ambulatory patients with heart failure: application of the MELD scoring system for outcome prediction.

• DOI: 10.1016/j.jacc.2012.12.056
• 发表时间: 2013-06-04
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: Kim, Margaret S.;Kato, Tomoko S.;Farr, Maryjane;Wu, Christina;Givens, Raymond C.;Collado, Ellias;Mancini, Donna M.;Schulze, P. Christian
• 通讯作者: Schulze, P. Christian

Human immunology studies using organ donors: Impact of clinical variations on immune parameters in tissues and circulation.

• DOI: 10.1111/ajt.14434
• 发表时间: 2018-01
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• 作者: Carpenter DJ;Granot T;Matsuoka N;Senda T;Kumar BV;Thome JJC;Gordon CL;Miron M;Weiner J;Connors T;Lerner H;Friedman A;Kato T;Griesemer AD;Farber DL
• 通讯作者: Farber DL