Administrative Core

行政核心

• 批准号: 10668162
• 负责人: Krishanu Saha
• 金额: $ 11.78万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-16 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668162
• 关键词: Administrator; Adopted; Animal Model; Area; Biology; Brain; Cell model; Cells; Clinic; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communication; Computer software; Data; Data Reporting; Data Set; Engineering; Ensure; Extramural Activities; Foundations; Genes; Goals; Grant; Human Resources; Infrastructure; Inherited; Institution; Lead; Leadership; Logistics; Occupational activity of managing finances; Patients; Personnel Management; Phase; Policies; Process; Protocols documentation; Publications; Reporting; Research; Research Personnel; Resources; Retina; Retinal Diseases; Science; Software Tools; Staff Work Load; Technology; Translations; United States Food and Drug Administration; United States National Institutes of Health; Universities; Validation; Vision; Wisconsin; Work; cost effective; data sharing; experience; genome editing; industry partner; innovation; manufacturing facility; manufacturing technology; meetings; member; nanoparticle delivery; pre-clinical; programs; somatic cell gene editing; synergism; therapeutic candidate; therapeutic genome editing; timeline

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE The CRISPR Vision Program is a truly team science unique effort to advance gene editing therapeutic candidates for several retinal channelopathies towards the clinic. This proposal leverages synergy between discoveries in engineering and biology and requires close collaborations and contacts between academic labs, industry partners, regulatory professionals, manufacturing facilities, the National Institutes of Health (NIH), and the U.S. Food and Drug Administration (FDA). This large effort therefore requires strong administrative support from the Administrative (Admin) Core, whose overarching goal is to ensure efficiency, teamwork, and synergy among the Projects and Cores by providing infrastructure spanning software, meetings, finances, staffing, logistics, communications, and publications. All these activities are critical to an innovative team science approach taken by the CRISPR Vision Program. The Admin Core builds on organizational principles that have proven successful during Phase I of the SCGE and several extramural projects since 2018. These principles include several supporting functions including communication, record keeping, process reports, publications, infrastructure, working relationships with university admin, software tools, and many more. In practice, four primary tasks will be executed. First, the Admin Core will assign and manage personnel to ensure all Projects and Cores are appropriately staffed and form committees to oversee all duties. The Admin Core will perform project management tasks based on the information they collect from regular meetings, comparison of progress to the phase timelines, and other factors. Second, the Admin Core will support communication and synergy among team members through organizing regular meetings, adopting standard practices for data and protocol sharing, and providing software tools to assist with project management and team communication. Third, the Admin Core will coordinate external communications of research, datasets, protocols, and processes including information sharing with the NIH, the SCGE Consortium Translational Coordination and Dissemination Center, and across other Centers, and dissemination and publication of results and resources. Finally, the Admin Core will provide financial management, interface with institutional administration, and ensure the cost-effective use of resources across the Projects and Cores. Overall, the Admin Core will help integrate the Projects so that true Team Science can be achieved within each Project and also between Projects. The points of synergy are expected to provide a rapid translation of promising genome editing technology into the clinic. The Admin Core will be led by Dr. Krishanu Saha, who brings leadership experience with many large team science initiatives including the Phase I of the SCGE. The Core will benefit from a Program Manager who will execute the tasks above with Dr. Saha and an experienced set of grants administrators at the University of Wisconsin-Madison.

项目摘要/摘要 - 行政核心 CRISPR Vision计划是一项真正的团队科学，旨在推进基因编辑疗法 对诊所的几种永久性通道病的候选人。该提议利用了协同作用 工程和生物学的发现，需要学术之间的密切合作和联系 实验室，行业合作伙伴，监管专业人员，制造设施，国立卫生研究院 （NIH）和美国食品和药物管理局（FDA）。因此，这种巨大的努力需要强大 行政（admin）核心的行政支持，其总体目标是确保效率， 团队合作，以及通过提供跨越基础架构软件的项目和核心之间的协同作用， 会议，财务，人员配备，物流，沟通和出版物。所有这些活动对 CRISPR Vision计划采取的创新团队科学方法。管理员核心建立 在SCGE的第一阶段和几个外壁外的组织原则 自2018年以来的项目。这些原则包括几个支持功能，包括沟通，记录 保存，处理报告，出版物，基础架构，与大学管理员的工作关系，软件 工具等等。实际上，将执行四个主要任务。首先，管理员核心将分配和 管理人员以确保所有项目和核心都适当人员，并成立了海外的委员会 所有职责。管理员核心将根据他们从中收集的信息执行项目管理任务 定期会议，比较相位时间表的比较以及其他因素。其次，管理员核心 通过组织定期会议，将支持团队成员之间的沟通和协同作用， 为数据和协议共享采用标准实践，并提供软件工具来协助项目 管理和团队沟通。第三，管理员核心将协调 研究，数据集，协议和流程，包括与NIH的信息共享，SCGE 财团翻译协调和传播中心，跨其他中心，以及 结果和资源的传播和发布。最后，管理员核心将提供财务 管理，与机构管理的互动，并确保在跨机构管理 项目和核心。总体而言，管理员核心将有助于整合项目，以便真正的团队科学 可以在每个项目中以及项目之间实现。预计协同点将提供 将承诺的基因组编辑技术的快速翻译成诊所。管理员核心将由博士领导。 克里沙努·萨哈（Krishanu Saha），他通过许多大型团队科学倡议，包括 SCGE的第一阶段。核心将受益于计划经理，该计划经理将执行上述任务 Saha博士和威斯康星大学麦迪逊分校的经验丰富的赠款管理员。