Administrative Core
行政核心
基本信息
- 批准号:10668162
- 负责人:
- 金额:$ 11.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-16 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdministratorAdoptedAnimal ModelAreaBiologyBrainCell modelCellsClinicClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCommunicationComputer softwareDataData ReportingData SetEngineeringEnsureExtramural ActivitiesFoundationsGenesGoalsGrantHuman ResourcesInfrastructureInheritedInstitutionLeadLeadershipLogisticsOccupational activity of managing financesPatientsPersonnel ManagementPhasePoliciesProcessProtocols documentationPublicationsReportingResearchResearch PersonnelResourcesRetinaRetinal DiseasesScienceSoftware ToolsStaff Work LoadTechnologyTranslationsUnited States Food and Drug AdministrationUnited States National Institutes of HealthUniversitiesValidationVisionWisconsinWorkcost effectivedata sharingexperiencegenome editingindustry partnerinnovationmanufacturing facilitymanufacturing technologymeetingsmembernanoparticle deliverypre-clinicalprogramssomatic cell gene editingsynergismtherapeutic candidatetherapeutic genome editingtimeline
项目摘要
PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE
The CRISPR Vision Program is a truly team science unique effort to advance gene editing therapeutic
candidates for several retinal channelopathies towards the clinic. This proposal leverages synergy between
discoveries in engineering and biology and requires close collaborations and contacts between academic
labs, industry partners, regulatory professionals, manufacturing facilities, the National Institutes of Health
(NIH), and the U.S. Food and Drug Administration (FDA). This large effort therefore requires strong
administrative support from the Administrative (Admin) Core, whose overarching goal is to ensure efficiency,
teamwork, and synergy among the Projects and Cores by providing infrastructure spanning software,
meetings, finances, staffing, logistics, communications, and publications. All these activities are critical to an
innovative team science approach taken by the CRISPR Vision Program. The Admin Core builds on
organizational principles that have proven successful during Phase I of the SCGE and several extramural
projects since 2018. These principles include several supporting functions including communication, record
keeping, process reports, publications, infrastructure, working relationships with university admin, software
tools, and many more. In practice, four primary tasks will be executed. First, the Admin Core will assign and
manage personnel to ensure all Projects and Cores are appropriately staffed and form committees to oversee
all duties. The Admin Core will perform project management tasks based on the information they collect from
regular meetings, comparison of progress to the phase timelines, and other factors. Second, the Admin Core
will support communication and synergy among team members through organizing regular meetings,
adopting standard practices for data and protocol sharing, and providing software tools to assist with project
management and team communication. Third, the Admin Core will coordinate external communications of
research, datasets, protocols, and processes including information sharing with the NIH, the SCGE
Consortium Translational Coordination and Dissemination Center, and across other Centers, and
dissemination and publication of results and resources. Finally, the Admin Core will provide financial
management, interface with institutional administration, and ensure the cost-effective use of resources across
the Projects and Cores. Overall, the Admin Core will help integrate the Projects so that true Team Science
can be achieved within each Project and also between Projects. The points of synergy are expected to provide
a rapid translation of promising genome editing technology into the clinic. The Admin Core will be led by Dr.
Krishanu Saha, who brings leadership experience with many large team science initiatives including the
Phase I of the SCGE. The Core will benefit from a Program Manager who will execute the tasks above with
Dr. Saha and an experienced set of grants administrators at the University of Wisconsin-Madison.
项目概要/摘要-行政核心
CRISPR Vision计划是一个真正的团队科学独特的努力,以推进基因编辑治疗
几种视网膜通道病变的候选人走向诊所。该提案利用了以下方面的协同作用:
工程和生物学的发现,需要学术界之间的密切合作和联系,
实验室、行业合作伙伴、监管专业人员、生产设施、美国国立卫生研究院
(NIH)和美国食品药品监督管理局(FDA)。因此,这一巨大的努力需要强有力的
行政(管理)核心的行政支持,其首要目标是确保效率,
通过提供跨越软件的基础设施,
会议、财务、人员配备、后勤、通信和出版物。所有这些活动对一个
CRISPR愿景计划采用的创新团队科学方法。管理核心建立在
在SCGE的第一阶段和几个校外实践中证明是成功的组织原则
项目自2018年以来。这些原则包括几个支持功能,包括通信,记录
保持,过程报告,出版物,基础设施,与大学管理,软件的工作关系
工具,还有更多。在实践中,将执行四项主要任务。首先,管理核心将分配和
管理人员,确保所有项目和核心都配备了适当的人员,并成立委员会进行监督
所有的职责。管理核心将根据他们收集的信息执行项目管理任务,
定期会议、进度与阶段时间表的比较以及其他因素。第二,管理核心
将通过组织定期会议,支持小组成员之间的沟通和协同作用,
采用数据和协议共享的标准做法,并提供软件工具以协助项目
管理和团队沟通。第三,管理核心将协调外部沟通,
研究、数据集、协议和流程,包括与NIH、SCGE的信息共享
联合翻译协调和传播中心,以及其他中心,以及
传播和出版成果和资源。最后,管理核心将提供财务
管理,与机构行政部门的接口,并确保以具有成本效益的方式使用资源,
项目和核心。总的来说,管理核心将有助于整合项目,使真正的团队科学
可以在每个项目中实现,也可以在项目之间实现。协同点预计将提供
将有前途的基因组编辑技术快速转化为临床。管理核心将由博士领导。
Krishanu Saha带来了许多大型团队科学计划的领导经验,包括
专家咨询小组第一阶段。核心将受益于一个项目经理,他将执行上述任务,
博士Saha和威斯康星大学麦迪逊分校一组经验丰富的赠款管理员。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Krishanu Saha其他文献
Krishanu Saha的其他文献
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{{ truncateString('Krishanu Saha', 18)}}的其他基金
The CRISPR Vision Program: Nonviral Genome Editing Platforms to Treat Inherited Retinal Channelopathies
CRISPR 视觉计划:治疗遗传性视网膜通道病的非病毒基因组编辑平台
- 批准号:
10668161 - 财政年份:2023
- 资助金额:
$ 11.78万 - 项目类别:
Streamlined development of an IND with the silica nanocapsule loaded with Cas9 genome editors to disrupt the dominant BEST1 mutant allele
使用装载有 Cas9 基因组编辑器的二氧化硅纳米胶囊简化 IND 的开发,以破坏占主导地位的 BEST1 突变等位基因
- 批准号:
10668168 - 财政年份:2023
- 资助金额:
$ 11.78万 - 项目类别:
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells
组装新型基因编辑颗粒以了解患者来源细胞中的基因组手术
- 批准号:
10618322 - 财政年份:2016
- 资助金额:
$ 11.78万 - 项目类别:
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells
组装新型基因编辑颗粒以了解患者来源细胞中的基因组手术
- 批准号:
9142548 - 财政年份:2016
- 资助金额:
$ 11.78万 - 项目类别:
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells
组装新型基因编辑颗粒以了解患者来源细胞中的基因组手术
- 批准号:
10410499 - 财政年份:2016
- 资助金额:
$ 11.78万 - 项目类别:
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells
组装新型基因编辑颗粒以了解患者来源细胞中的基因组手术
- 批准号:
10206480 - 财政年份:2016
- 资助金额:
$ 11.78万 - 项目类别:
Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells
组装新型基因编辑颗粒以了解患者来源细胞中的基因组手术
- 批准号:
9335383 - 财政年份:2016
- 资助金额:
$ 11.78万 - 项目类别:
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