Penn State Clinical and Translational Science Institute

宾夕法尼亚州立大学临床与转化科学研究所

• 批准号: 10670917
• 负责人: Jennifer L. Kraschnewski
• 金额: $ 379.54万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670917
• 关键词: 3-Dimensional; Clinical Sciences; FGF7 gene; Translational Research

PROJECT SUMMARY ABSTRACT - OVERALL The Penn State Clinical and Translational Science Institute (CTSI) was formed in 2007 to accelerate the impact of biomedical research on health. Penn State has almost $1 billion in research expenditures, and its College of Medicine (CoM) and Penn State Health system serve about 2.0 million people in largely rural regions of central PA. Penn State is the state's land-grant university, a research institution with a strong culture of interdisciplinary team science and a health system committed to the people and communities in our area. We have developed a growing outreach network and partnerships to better understand the communities' needs, address barriers to prevention and treatment, and test novel approaches to health concerns across the lifespan and translational spectrum. As a learning organization, we practice continuous evaluation and data-driven decision-making to achieve continuous quality improvement. Our vision is to be the cornerstone of CTS throughout Penn State and a leader in advancing rural CTS. A key component of our vision is that interdisciplinary teamwork and broad engagement of stakeholders is critical to success. Our specific aims are: Aim 1. Catalyze CTS by engaging researchers, providers and community partners. We will engage researchers and establish unique partnerships across and beyond Penn State. We will capitalize on vast sources of health-relevant data to inform novel approaches to health concerns and social and environmental implications, particularly as they relate to our rural population. We will integrate rural community engagement and collaboration through community activities, consultation services, workforce training, and pilot projects. Aim 2. Promote CTS through innovation and investigator-centered research infrastructure that accelerates protocol development and study completion while ensuring scientific rigor and reproducibility. CTSI provides expansive research support and services to conduct CTS research and clinical trials that meet the needs of the communities we serve. We will pursue the establishment of an academic Clinical Informatics Research Division at the CoM and promote integration with the sophisticated informatics capabilities across Penn State. These efforts will empower scientists across the University. Aim 3. Effectively share resources and expertise through collaboration with other CTSA Hubs and the Consortium. We are active members of the CTSA (Clinical and Translational Science Award) Consortium. We will increase our interactions, focusing on Hub collaborations germane to rural communities. Aim 4. Educate a new generation of health professionals and CTS scholars, and empower them to conduct funded, innovative and interdisciplinary research. The Institute will be the focal point for the training of a diverse and expanding CTS workforce of scholars and professionals across Penn State, the CTSA Consortium and our new partnerships.

项目摘要摘要 - 总体 宾夕法尼亚州立大学临床与转化科学研究所 (CTSI) 成立于 2007 年，旨在加速影响 健康生物医学研究。宾夕法尼亚州立大学拥有近 10 亿美元的研究支出，其学院 Medicine (CoM) 和宾夕法尼亚州立大学卫生系统为中部大部分农村地区的约 200 万人提供服务 宾夕法尼亚州。宾夕法尼亚州立大学是该州的赠地大学，是一所具有浓厚跨学科文化的研究机构 团队科学和致力于我们地区人民和社区的卫生系统。我们开发了一个 不断扩大外展网络和伙伴关系，以更好地了解社区的需求，解决障碍 预防和治疗，并测试解决整个生命周期和转化健康问题的新方法 光谱。作为一个学习型组织，我们实践持续评估和数据驱动的决策 实现持续的质量改进。我们的愿景是成为整个宾夕法尼亚州立大学 CTS 的基石， 推进农村CTS的领导者。我们愿景的一个关键组成部分是跨学科的团队合作和广泛的合作 利益相关者的参与对于成功至关重要。我们的具体目标是： 目标 1. 通过研究人员、提供者和社区合作伙伴的参与来促进 CTS。我们将参与 研究人员并在宾夕法尼亚州立大学内外建立独特的合作伙伴关系。我们将利用广泛的资源 与健康相关的数据，为解决健康问题以及社会和环境影响提供新方法， 特别是因为它们与我们的农村人口有关。我们将整合农村社区的参与和 通过社区活动、咨询服务、劳动力培训和试点项目进行合作。 目标 2. 通过创新和以研究者为中心的研究基础设施来促进 CTS 加速方案开发和研究完成，同时确保科学严谨性和 再现性。 CTSI 提供广泛的研究支持和服务来进行 CTS 研究和临床 满足我们所服务社区需求的试验。我们将致力于建立学术临床 CoM 信息学研究部门，促进与先进信息学能力的整合 横跨宾夕法尼亚州立大学。这些努力将为整个大学的科学家提供支持。 目标 3. 通过与其他 CTSA 中心和组织合作，有效共享资源和专业知识 财团。我们是 CTSA（临床和转化科学奖）联盟的活跃成员。我们 将增加我们的互动，重点关注与农村社区密切相关的中心合作。 目标 4. 教育新一代卫生专业人员和 CTS 学者，并使他们能够 开展资助的、创新的和跨学科的研究。该研究所将成为培训的焦点 CTSA 由宾夕法尼亚州立大学的学者和专业人士组成的多元化且不断扩大的 CTS 员工队伍组成 财团和我们的新合作伙伴。

项目成果

Randomized controlled trial comparing operative times between standard and robot-assisted laparoscopic hysterectomy.

比较标准腹腔镜子宫切除术和机器人辅助腹腔镜子宫切除术的手术时间的随机对照试验。

• DOI: 10.1002/ijgo.12001
• 发表时间: 2017-01
• 期刊: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
• 作者: Deimling TA;Eldridge JL;Riley KA;Kunselman AR;Harkins GJ
• 通讯作者: Harkins GJ

A retrospective analysis of complications associated with postpartum hemorrhage up to 1 year postpartum in mothers with and without a pre-existing mental health diagnosis.

• DOI: 10.1177/17455057231211094
• 发表时间: 2023-01
• 期刊: WOMENS HEALTH
• 影响因子: 2.4
• 作者: Endres, Kodi;Razavi, Nina;Tian, Zizhong;Zhou, Shouhao;Krawiec, Conrad;Jasani, Sona
• 通讯作者: Jasani, Sona

Evaluating the Impact of Aevidum on Mental Health Knowledge, Attitudes, and Help-Seeking Behaviors in High School Students: A Mixed-Methods Study.

• DOI: 10.1177/08901171231204473
• 发表时间: 2024-01
• 期刊: AMERICAN JOURNAL OF HEALTH PROMOTION
• 影响因子: 2.7
• 作者: Pattison, Krista L.;Lehman, Erik;Molinari, Alissa;Costigan, Heather;Pileggi, Francesca;Stuckey, Heather;Sekhar, Deepa L.
• 通讯作者: Sekhar, Deepa L.

iScore: An MPI supported software for ranking protein–protein docking models based on a random walk graph kernel and support vector machines

iScore：一款 MPI 支持的软件，用于基于随机游走图内核和支持向量机对蛋白质对接模型进行排名

• DOI: 10.1016/j.softx.2020.100462
• 发表时间: 2020
• 期刊: SoftwareX
• 影响因子: 3.4
• 作者: Renaud, Nicolas;Jung, Yong;Honavar, Vasant;Geng, Cunliang;Bonvin, Alexandre M.J.J.;Xue, Li C.
• 通讯作者: Xue, Li C.

Temporal Causality Analysis of Sentiment Change in a Cancer Survivor Network.

• DOI: 10.1109/tcss.2016.2591880
• 发表时间: 2016-06
• 期刊: IEEE transactions on computational social systems
• 影响因子: 5
• 作者: Bui N;Yen J;Honavar V
• 通讯作者: Honavar V