Penn State Clinical and Translational Science Institute

宾夕法尼亚州立大学临床与转化科学研究所

• 批准号: 10670917
• 负责人: Jennifer L. Kraschnewski
• 金额: $ 379.54万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670917
• 关键词: 3-Dimensional; Clinical Sciences; FGF7 gene; Translational Research

PROJECT SUMMARY ABSTRACT - OVERALL The Penn State Clinical and Translational Science Institute (CTSI) was formed in 2007 to accelerate the impact of biomedical research on health. Penn State has almost $1 billion in research expenditures, and its College of Medicine (CoM) and Penn State Health system serve about 2.0 million people in largely rural regions of central PA. Penn State is the state's land-grant university, a research institution with a strong culture of interdisciplinary team science and a health system committed to the people and communities in our area. We have developed a growing outreach network and partnerships to better understand the communities' needs, address barriers to prevention and treatment, and test novel approaches to health concerns across the lifespan and translational spectrum. As a learning organization, we practice continuous evaluation and data-driven decision-making to achieve continuous quality improvement. Our vision is to be the cornerstone of CTS throughout Penn State and a leader in advancing rural CTS. A key component of our vision is that interdisciplinary teamwork and broad engagement of stakeholders is critical to success. Our specific aims are: Aim 1. Catalyze CTS by engaging researchers, providers and community partners. We will engage researchers and establish unique partnerships across and beyond Penn State. We will capitalize on vast sources of health-relevant data to inform novel approaches to health concerns and social and environmental implications, particularly as they relate to our rural population. We will integrate rural community engagement and collaboration through community activities, consultation services, workforce training, and pilot projects. Aim 2. Promote CTS through innovation and investigator-centered research infrastructure that accelerates protocol development and study completion while ensuring scientific rigor and reproducibility. CTSI provides expansive research support and services to conduct CTS research and clinical trials that meet the needs of the communities we serve. We will pursue the establishment of an academic Clinical Informatics Research Division at the CoM and promote integration with the sophisticated informatics capabilities across Penn State. These efforts will empower scientists across the University. Aim 3. Effectively share resources and expertise through collaboration with other CTSA Hubs and the Consortium. We are active members of the CTSA (Clinical and Translational Science Award) Consortium. We will increase our interactions, focusing on Hub collaborations germane to rural communities. Aim 4. Educate a new generation of health professionals and CTS scholars, and empower them to conduct funded, innovative and interdisciplinary research. The Institute will be the focal point for the training of a diverse and expanding CTS workforce of scholars and professionals across Penn State, the CTSA Consortium and our new partnerships.

项目摘要摘要 - 总体 宾夕法尼亚州立大学临床和转化科学研究所（CTSI）于2007年成立，以加速影响 生物医学健康研究。宾夕法尼亚州立大学有近10亿美元的研究支出及其学院 医学（COM）和宾夕法尼亚州卫生系统在中央农村地区为约200万人提供服务 PA。宾夕法尼亚州立大学是该州的土地授予大学，该大学具有强烈的跨学科文化 团队科学和卫生系统致力于我们地区的人民和社区。我们已经开发了 发展推广网络和合作伙伴关系，以更好地了解社区的需求，解决障碍 预防和治疗，并测试整个生命周期和翻译的健康问题的新颖方法 光谱。作为一个学习组织，我们练习持续的评估和数据驱动的决策 实现持续的质量改进。我们的愿景是成为宾夕法尼亚州和 推进农村CTS的领导者。我们愿景的关键组成部分是跨学科的团队合作和广泛 利益相关者的参与对于成功至关重要。我们的具体目的是： AIM1。通过吸引研究人员，提供者和社区合作伙伴来催化CT。我们将参与 研究人员并在宾夕法尼亚州立大学建立独特的伙伴关系。我们将利用大量资源 与健康相关的数据，以为健康问题以及社会和环境影响提供新颖的方法， 特别是当它们与我们的农村人口有关时。我们将整合农村社区的参与和 通过社区活动，咨询服务，劳动力培训和试点项目的合作。 目标2。通过创新和以研究者为中心的研究基础设施来促进CTS 加速协议开发和研究完成，同时确保科学严谨和 可重复性。 CTSI提供了广泛的研究支持和服务，以进行CTS研究和临床 满足我们服务社区需求的试验。我们将建立学术临床 COM的信息学研究部，并促进与复杂的信息学能力的融合 在宾夕法尼亚州。这些努力将增强整个大学的科学家。 目标3。通过与其他CTSA枢纽合作有效地共享资源和专业知识 财团。我们是CTSA（临床和转化科学奖）财团的活跃成员。我们 将增加我们的互动，专注于与农村社区的枢纽合作。 目标4。教育新一代的卫生专业人员和CTS学者，并授权他们 进行资助，创新和跨学科研究。该研究所将成为培训的焦点 宾夕法尼亚州立大学的学者和专业人士的多元化和不断扩大的CTS劳动力 财团和我们的新合作伙伴关系。

项目成果

Dietary Patterns Affect the Gut Microbiome-The Link to Risk of Cardiometabolic Diseases.

• DOI: 10.1093/jn/nxy141
• 发表时间: 2018-09-01
• 期刊: The Journal of nutrition
• 作者: Tindall AM;Petersen KS;Kris-Etherton PM
• 通讯作者: Kris-Etherton PM

Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk.

• DOI: 10.3389/fneur.2017.00501
• 发表时间: 2017
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Zhang L;Wang X;Wang M;Sterling NW;Du G;Lewis MM;Yao T;Mailman RB;Li R;Huang X
• 通讯作者: Huang X

Transdiagnostic and functional predictors of depression severity and trajectory in the Penn state psychiatry clinical assessment and rating evaluation system (PCARES) registry.

• DOI: 10.1016/j.jad.2021.10.048
• 发表时间: 2022-02-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Gomaa, Hassaan;Baweja, Ritika;Mukherjee, Dahlia;He, Fan;Pearl, Amanda M.;Waschbusch, Daniel A.;Aksu, Errol A.;Liao, Duanping;Saunders, Erika F. H.
• 通讯作者: Saunders, Erika F. H.

Psychometric Analysis of the Rapid Eating Assessment for Participants-Short Form to Evaluate Dietary Quality in a Pre-Surgical Bariatric Population.

• DOI: 10.3390/nu15153372
• 发表时间: 2023-07-29
• 期刊: Nutrients
• 影响因子: 5.9

A Retrospective Comparative Cohort Study of Craniotomy and Prophylactic Enoxaparin Timing.

• DOI: 10.7759/cureus.23867
• 发表时间: 2022-04
• 期刊: CUREUS JOURNAL OF MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Hallan, David R.;Sciscent, Bao;Rizk, Elias
• 通讯作者: Rizk, Elias