权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Phase resolved ARF optical coherence elastography for intravascular imaging

用于血管内成像的相分辨 ARF 光学相干弹性成像

基本信息

批准号：
10670744
负责人：
ZHONGPING CHEN
金额：
$ 75.31万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670744
关键词：
Acoustics Acute Coronary Event Adipose tissue Algorithms American Animal Disease Models Animal Model Arterial Fatty Streak Arteries Basic Science Benchmarking Biomechanics Blood Vessels Calibration Cardiology Cardiovascular Diseases Cardiovascular system Catheters Cause of Death Cessation of life Characteristics Chemicals Clinical Consultations Development Diagnosis Disease Management Disease Progression Distal Early Diagnosis Elasticity Evaluation Funding Histologic Image Imaging Techniques Imaging technology Lasers Length Lesion Light Maps Measurement Medical Device Methods Modality Monitor Morphologic artifacts Morphology Motion Near-Infrared Spectroscopy Optical Coherence Tomography Optics Oryctolagus cuniculus Outcome Pathogenesis Pathologist Penetration Persons Phase Physicians Procedures Property Protocols documentation Radiation Resolution Risk Roentgen Rays Rupture Safety Scanning Scheme Source Speed Stress System Techniques Technology Therapeutic Intervention Time Tissues Ultrasonics Ultrasonography United States Validation Visualization Work atherosclerotic plaque rupture clinical translation cost design and construction elastography human error imaging modality imaging probe imaging system improved in vivo in vivo imaging instrument meter multimodality optical imaging plaque lesion porcine model tool ultrasound

项目摘要

PROJECT SUMMARY Cardiovascular disease is responsible for 1 in 4 deaths, or 650,000 Americans, every year. It is the leading cause of death in the United States. Ruptured atherosclerotic plaques are the main cause of acute coronary events, and it is of lethal consequence. Clinically, early detection of the latent vulnerability of plaques is the first line of defense against such deadly circumstances, and it relies on visualizing both tissue structural and biomechanical properties. Accurate characterization of a plaque lesion can facilitate better treatment management by further our understanding in the disease progression. The long-term objective of this proposal is to develop a multimodal intravascular imaging system that combines optical coherence tomography (OCT), ultrasound imaging (US), and shear-wave-based optical coherence elastography (OCESW) for studying and characterizing plaque vulnerability. The proposed system, IVOCT-US-OCESW, is built upon the ARF-OCE technology developed in the preceding proposal, with several significant technical advancements that will further facilitate its clinical translation. The proposed IVOCT-US- OCESW system unifies the high spatial resolution and extended penetration depth of the 1.7-µm OCT, the broad imaging depth of US, and the enhanced biomechanical contrast of OCESW. It will provide physicians a powerful clinical instrument for studying, diagnosing, and managing vulnerable plaques. The multimodal probe only requires a single disposable guide wire and catheter, thereby reducing the costs, procedure length, associated risks, and X-ray exposure. Our specific aims are to: 1) Design and construct a multimodal IVOCT-US-OCESW imaging probe; 2) Develop the IVOCT-US-OCESW system featuring a 4-MHz, 1.7-µm laser; 3) Establish a scanning protocol and algorithms for biomechanical property quantification; 4) Demonstrate the efficacy of the proposed system in normal and diseased animal models. We expect the development of the proposed high-speed, high-penetration-depth, and high-sensitivity IVOCT-US-OCESW system and probe to have significant impact to both basic science and clinical understanding of plaque pathogenesis. This will enhance the clinicians’ ability to identify vulnerable lesions, tailor interventional therapy, and monitor disease progression. More importantly, it will be a powerful tool that provides a quantitative means to benchmark and evaluate new medical devices and therapies.

项目概要心血管疾病每年导致四分之一的美国人死亡，即 65 万美国人。它是美国的首要死因。动脉粥样硬化斑块破裂是急性发作的主要原因冠状动脉事件，并且具有致命的后果。临床上，早期发现斑块的潜在脆弱性是抵御这种致命情况的第一道防线，它依赖于组织结构的可视化和生物力学特性。准确表征斑块病变有助于更好的治疗通过进一步了解疾病进展来进行管理。该提案的长期目标是开发一种多模态血管内成像系统结合了光学相干断层扫描 (OCT)、超声成像 (US) 和基于剪切波的光学相干弹性成像 (OCESW) 用于研究和表征斑块脆弱性。拟议的系统， IVOCT-US-OCESW，建立在之前提案中开发的 ARF-OCE 技术之上，具有多个重大技术进步将进一步促进其临床转化。拟议的 IVOCT-US- OCESW 系统结合了 1.7 µm OCT 的高空间分辨率和扩展的穿透深度，广泛应用于 US 的成像深度和 OCESW 的增强生物力学对比度。将为医生提供强大的用于研究、诊断和管理易损斑块的临床仪器。仅多模态探头需要单个一次性导丝和导管，从而降低成本、手术时间和相关风险和 X 射线暴露。我们的具体目标是： 1) 设计和建造多式联运 IVOCT-US-OCESW 成像探头； 2) 开发具有 4 MHz、1.7 µm 激光器的 IVOCT-US-OCESW 系统； 3）建立一个用于生物力学特性量化的扫描协议和算法； 4) 证明其功效在正常和患病动物模型中提出的系统。我们期待所提出的高速、高穿透深度和高灵敏度的发展 IVOCT-US-OCESW 系统和探针对基础科学和临床理解产生重大影响斑块的发病机制。这将增强临床医生识别易损病变、定制介入治疗的能力治疗，并监测疾病进展。更重要的是，它将成为一个提供定量分析的强大工具。是指对新的医疗设备和疗法进行基准测试和评估。

项目成果

期刊论文数量（56）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

3D mapping of elastic modulus using shear wave optical micro-elastography.

DOI：
10.1038/srep35499
发表时间：
2016-10-20
期刊：
Scientific reports
影响因子：
4.6
作者：
Zhu J;Qi L;Miao Y;Ma T;Dai C;Qu Y;He Y;Gao Y;Zhou Q;Chen Z
通讯作者：
Chen Z

High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser.

DOI：
10.1038/srep06889
发表时间：
2014-11-04
期刊：
Scientific reports
影响因子：
4.6
作者：
Wang P;Ma T;Slipchenko MN;Liang S;Hui J;Shung KK;Roy S;Sturek M;Zhou Q;Chen Z;Cheng JX
通讯作者：
Cheng JX

Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER].

集成血管内超声和光学相干断层扫描技术：一种有前途的识别易损斑块的工具[特邀论文]。