Phase resolved ARF optical coherence elastography for intravascular imaging

用于血管内成像的相分辨 ARF 光学相干弹性成像

基本信息

批准号：
9061010
负责人：
ZHONGPING CHEN
金额：
$ 72.16万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-15 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9061010
关键词：
Acoustics Adipose tissue Algorithms Americas Animal Model Area Arterial Fatty Streak Arteries Atherosclerosis Biomechanics Blood Vessels Blood coagulation Blood flow Brain Aneurysms California Cardiology Cardiovascular Diseases Cardiovascular system Carotid Artery Ulcerating Plaque Catheters Cessation of life Clinical Clinical Management Clinical Trials Collaborations Complex Development Diagnosis Disease Disease Progression Early Diagnosis Engineering Epidemic Family suidae Grant Hospitals Image Imagery Imaging Device In Vitro Institutes Institution Lasers Lesion Measures Medicine Modeling Monitor Morbidity - disease rate Multimodal Imaging Myocardial Infarction Optical Coherence Tomography Optics Oryctolagus cuniculus Pathologist Pathology Patients Penetration Phase Physician Executives Physicians Prevention Procedures Property Radiation Research Research Personnel Resolution Resources Risk Rupture Scientist Speed Stimulus Stress Symptoms System Technology Therapeutic Intervention Thick Thrombus Tissues Transducers Treatment Efficacy Ultrasonic Transducer Ultrasonography United States National Institutes of Health Universities arterial remodeling cardiovascular imaging clinical application cost design elastography human subject image reconstruction imaging modality imaging probe imaging system improved in vivo inflammatory marker mortality outcome forecast plaque lesion prevent public health relevance success tool

项目摘要

DESCRIPTION (provided by applicant): The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution of OCT, the broad imaging depth of US, and the biomechanical contrast of ARF-OCE. Visualizing plaques to help understand the progression of disease and to aid in diagnosis and treatment is highly desirable. Both in vitro and in vivo studies have shown that fatty tissue has a higher strain than fibrous plaques and that vulnerable plaques are in high strain areas surrounded by low strain areas. More recent studies have pointed to the vulnerability and the risk of rupturing of plaques being related to the stress on the fibrous cap, the cap thickness, arterial remodeling, and the composition of the plaques. Therefore, it is important to measure the biomechanical properties of the artery tissue to monitor the atherosclerosis to reduce the rupture proneness of an artery and to correlate with clinical symptoms and inflammation markers. The combined multimodal vascular imaging system will permit cross-sectional visualization of vasculature with high spatial resolution, broad imaging depth, and high biomechanical sensitivity, which is not possible by any of these technologies alone. The integrated OCT/US/ARF-OCE will provide the physician with a powerful tool for imaging, diagnosing, and managing vulnerable plaques. Furthermore, this multi-modal imaging strategy in a single system permits the use of a single disposable guide wire and catheter, thereby reducing costs to hospitals and patients, and improving prognosis by early detection. The specific aims are: (1) Design and develop an integrated intravascular OCT/US/ARF-OCE imaging probe, (2) Design and develop an integrated intravascular OCT/US/ARF-OCE system, (3) Develop algorithms for image reconstruction and biomechanical property determination, (4) Image cardiovascular plaques in rabbits and porcine animal models using an integrated OCT/US/ARF-OCE system, and (5) Demonstrate clinical applications of the integrated multimodal imaging system in pilot in vivo human subject studies. The proposed research is expected to have significant impact in the earlier detection, prevention, and treatment of cardiovascular diseases. PHS 398

描述（由申请人提供）：提议的授予的广泛，长期的目标是开发一个集成的多模式内血管内成像系统，该系统结合了血管内光学相干层析成像（OCT），超声（US）和相位分辨的声学辐射力光学相干弹性（ARF-OCE）。多模式的血管内成像系统的独特之处在于它结合了OCT高空间分辨率，我们的广泛成像深度和ARF-OCE的生物力学对比的优势。非常需要可视化斑块以帮助了解疾病的进展并帮助诊断和治疗。体外和体内研究都表明，脂肪组织的应变比纤维斑块更高，并且易受伤害的斑块位于高应变区域的高应变区域。最近的研究表明，与纤维帽，盖厚度，动脉重塑和斑块组成有关的斑块的脆弱性和风险。因此，重要的是要测量动脉组织的生物力学特性，以监测动脉粥样硬化以降低动脉的破裂倾斜度并与临床症状和炎症标记相关。组合的多模式血管成像系统将允许具有高空间分辨率，广泛的成像深度和高生物力学灵敏度的脉管系统的横截面可视化，仅此这些技术都是不可能的。综合的OCT/US/ARF-OCE将为医生提供一个强大的工具，用于成像，诊断和管理脆弱的斑块。此外，单个系统中的这种多模式成像策略允许使用单个一次性导管和导管，从而降低了医院和患者的成本，并通过早期检测来改善预后。 The specific aims are: (1) Design and develop an integrated intravascular OCT/US/ARF-OCE imaging probe, (2) Design and develop an integrated intravascular OCT/US/ARF-OCE system, (3) Develop algorithms for image reconstruction and biomechanical property determination, (4) Image cardiovascular plaques in rabbits and porcine animal models using an integrated OCT/US/ARF-OCE系统和（5）证明了综合多模式成像系统在体内人类学科研究中的临床应用。拟议的研究预计将对心血管疾病的早期发现，预防和治疗产生重大影响。 PHS 398