Phase resolved ARF optical coherence elastography for intravascular imaging
用于血管内成像的相分辨 ARF 光学相干弹性成像
基本信息
- 批准号:9061010
- 负责人:
- 金额:$ 72.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-15 至 2018-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAdipose tissueAlgorithmsAmericasAnimal ModelAreaArterial Fatty StreakArteriesAtherosclerosisBiomechanicsBlood VesselsBlood coagulationBlood flowBrain AneurysmsCaliforniaCardiologyCardiovascular DiseasesCardiovascular systemCarotid Artery Ulcerating PlaqueCathetersCessation of lifeClinicalClinical ManagementClinical TrialsCollaborationsComplexDevelopmentDiagnosisDiseaseDisease ProgressionEarly DiagnosisEngineeringEpidemicFamily suidaeGrantHospitalsImageImageryImaging DeviceIn VitroInstitutesInstitutionLasersLesionMeasuresMedicineModelingMonitorMorbidity - disease rateMultimodal ImagingMyocardial InfarctionOptical Coherence TomographyOpticsOryctolagus cuniculusPathologistPathologyPatientsPenetrationPhasePhysician ExecutivesPhysiciansPreventionProceduresPropertyRadiationResearchResearch PersonnelResolutionResourcesRiskRuptureScientistSpeedStimulusStressSymptomsSystemTechnologyTherapeutic InterventionThickThrombusTissuesTransducersTreatment EfficacyUltrasonic TransducerUltrasonographyUnited States National Institutes of HealthUniversitiesarterial remodelingcardiovascular imagingclinical applicationcostdesignelastographyhuman subjectimage reconstructionimaging modalityimaging probeimaging systemimprovedin vivoinflammatory markermortalityoutcome forecastplaque lesionpreventpublic health relevancesuccesstool
项目摘要
DESCRIPTION (provided by applicant): The broad, long term objective of the proposed grant is to develop an integrated multimodal intravascular imaging system that combines intravascular optical coherence tomography (OCT), ultrasound (US), and phase-resolved acoustic radiation force optical coherence elastography (ARF-OCE). The multimodal intravascular imaging system is unique in that it combines the advantages of the high spatial resolution of OCT, the broad imaging depth of US, and the biomechanical contrast of ARF-OCE. Visualizing plaques to help understand the progression of disease and to aid in diagnosis and treatment is highly desirable. Both in vitro and in vivo studies have shown that fatty tissue has a higher strain than fibrous plaques and that vulnerable plaques are in high strain areas surrounded by low strain areas. More recent studies have pointed to the vulnerability and the risk of rupturing of plaques being related to the stress on the fibrous cap, the cap thickness, arterial remodeling, and the composition of the plaques. Therefore, it is important to measure the biomechanical properties of the artery tissue to monitor the atherosclerosis to reduce the rupture proneness of an artery and to correlate with clinical symptoms and inflammation markers. The combined multimodal vascular imaging system will permit cross-sectional visualization of vasculature with high spatial resolution, broad imaging depth, and high biomechanical sensitivity, which is not possible by any of these technologies alone. The integrated OCT/US/ARF-OCE will provide the physician with a powerful tool for imaging, diagnosing, and managing vulnerable plaques. Furthermore, this multi-modal imaging strategy in a single system permits the use of a single disposable guide wire and catheter, thereby reducing costs to hospitals and patients, and improving prognosis by early detection. The specific aims are: (1) Design and develop an integrated intravascular OCT/US/ARF-OCE imaging probe, (2) Design and develop an integrated intravascular OCT/US/ARF-OCE system, (3) Develop algorithms for image reconstruction and biomechanical property determination, (4) Image cardiovascular plaques in rabbits and porcine animal models using an integrated OCT/US/ARF-OCE system, and (5) Demonstrate clinical applications of the integrated multimodal imaging system in pilot in vivo human subject studies. The proposed research is expected to have significant impact in the earlier detection, prevention, and treatment of cardiovascular diseases. PHS 398
描述(由申请人提供):拟议资助的广泛、长期目标是开发一种集成的多模式血管内成像系统,该系统结合了血管内光学相干断层扫描(OCT)、超声(US)和相位分辨声辐射力光学相干弹性成像(ARF-OCE)。多模式血管内成像系统的独特之处在于,它结合了OCT的高空间分辨率、US的宽成像深度和ARF-OCE的生物力学对比度的优点。可视化斑块以帮助了解疾病的进展并帮助诊断和治疗是非常可取的。体外和体内研究都表明,脂肪组织比纤维斑块具有更高的应变,并且易损斑块位于被低应变区域包围的高应变区域中。最近的研究指出,斑块的脆弱性和破裂的风险与纤维帽上的应力、帽厚度、动脉重塑和斑块的组成有关。因此,重要的是测量动脉组织的生物力学性质以监测动脉粥样硬化,从而减少动脉的破裂倾向并与临床症状和炎症标志物相关联。组合的多模式血管成像系统将允许具有高空间分辨率、宽成像深度和高生物力学灵敏度的脉管系统的横截面可视化,这是单独使用这些技术中的任何一种都不可能实现的。集成的OCT/US/ARF-OCE将为医生提供成像、诊断和管理易损斑块的强大工具。此外,在单个系统中的这种多模式成像策略允许使用单个一次性导丝和导管,从而降低医院和患者的成本,并通过早期检测改善预后。具体目标是:(1)设计和开发集成的血管内OCT/US/ARF-OCE成像探头,(2)设计和开发集成的血管内OCT/US/ARF-OCE系统,(3)开发用于图像重建和生物力学性质测定的算法,(4)使用集成的OCT/US/ARF-OCE系统对兔和猪动物模型的心血管斑块进行成像,以及(5)展示集成多模态成像系统在试验性体内人类受试者研究中的临床应用。这项研究有望对心血管疾病的早期检测、预防和治疗产生重大影响。小灵通398
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ZHONGPING CHEN其他文献
ZHONGPING CHEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ZHONGPING CHEN', 18)}}的其他基金
Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy
通过多功能 OCT/OCTA 内窥镜持续监测和管理阴道健康
- 批准号:
10297772 - 财政年份:2021
- 资助金额:
$ 72.16万 - 项目类别:
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology
使用相位分辨光学成像技术对纤毛跳动动力学进行体内成像和量化
- 批准号:
10201599 - 财政年份:2020
- 资助金额:
$ 72.16万 - 项目类别:
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology
使用相位分辨光学成像技术对纤毛跳动动力学进行体内成像和量化
- 批准号:
10033635 - 财政年份:2020
- 资助金额:
$ 72.16万 - 项目类别:
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology
使用相位分辨光学成像技术对纤毛跳动动力学进行体内成像和量化
- 批准号:
10381672 - 财政年份:2020
- 资助金额:
$ 72.16万 - 项目类别:
High-resolution Elastographic Assessment of the Optic Nerve Head
视神经乳头的高分辨率弹性成像评估
- 批准号:
9900001 - 财政年份:2018
- 资助金额:
$ 72.16万 - 项目类别:
High-resolution Elastographic Assessment of the Optic Nerve Head
视神经乳头的高分辨率弹性成像评估
- 批准号:
10162604 - 财政年份:2018
- 资助金额:
$ 72.16万 - 项目类别:
Combined OCT/US/PAT system for intravascular Imaging
用于血管内成像的组合 OCT/US/PAT 系统
- 批准号:
9259809 - 财政年份:2015
- 资助金额:
$ 72.16万 - 项目类别:
Combined OCT/US/PAT system for intravascular Imaging
用于血管内成像的组合 OCT/US/PAT 系统
- 批准号:
9042035 - 财政年份:2015
- 资助金额:
$ 72.16万 - 项目类别:
Combined OCT/US/PAT system for intravascular Imaging
用于血管内成像的组合 OCT/US/PAT 系统
- 批准号:
8871465 - 财政年份:2015
- 资助金额:
$ 72.16万 - 项目类别:
Phase resolved ARF optical coherence elastography for intravascular imaging
用于血管内成像的相分辨 ARF 光学相干弹性成像
- 批准号:
10670744 - 财政年份:2014
- 资助金额:
$ 72.16万 - 项目类别:
相似海外基金
Deciphering the role of adipose tissue in common metabolic disease via adipose tissue proteomics
通过脂肪组织蛋白质组学解读脂肪组织在常见代谢疾病中的作用
- 批准号:
MR/Y013891/1 - 财政年份:2024
- 资助金额:
$ 72.16万 - 项目类别:
Research Grant
ESTABLISHING THE ROLE OF ADIPOSE TISSUE INFLAMMATION IN THE REGULATION OF MUSCLE MASS IN OLDER PEOPLE
确定脂肪组织炎症在老年人肌肉质量调节中的作用
- 批准号:
BB/Y006542/1 - 财政年份:2024
- 资助金额:
$ 72.16万 - 项目类别:
Research Grant
Canadian Alliance of Healthy Hearts and Minds: Dissecting the Pathways Linking Ectopic Adipose Tissue to Cognitive Dysfunction
加拿大健康心灵联盟:剖析异位脂肪组织与认知功能障碍之间的联系途径
- 批准号:
479570 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别:
Operating Grants
Determinants of Longitudinal Progression of Adipose Tissue Inflammation in Individuals at High-Risk for Type 2 Diabetes: Novel Insights from Metabolomic Profiling
2 型糖尿病高危个体脂肪组织炎症纵向进展的决定因素:代谢组学分析的新见解
- 批准号:
488898 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别:
Operating Grants
Activation of human brown adipose tissue using food ingredients that enhance the bioavailability of nitric oxide
使用增强一氧化氮生物利用度的食品成分激活人体棕色脂肪组织
- 批准号:
23H03323 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of new lung regeneration therapies by elucidating the lung regeneration mechanism of adipose tissue-derived stem cells
通过阐明脂肪组织干细胞的肺再生机制开发新的肺再生疗法
- 批准号:
23K08293 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study on the role of brown adipose tissue in the development and maintenance of skeletal muscles
棕色脂肪组织在骨骼肌发育和维持中作用的研究
- 批准号:
23K19922 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Adipose Tissue T Cell Polarization and Metabolic Health in Persons Living with HIV
HIV 感染者的脂肪组织 T 细胞极化和代谢健康
- 批准号:
10619176 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别:
Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
下丘脑腹内侧区的雌激素信号调节脂肪组织代谢适应
- 批准号:
10604611 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别:
Obesity and Childhood Asthma: The Role of Adipose Tissue
肥胖和儿童哮喘:脂肪组织的作用
- 批准号:
10813753 - 财政年份:2023
- 资助金额:
$ 72.16万 - 项目类别: