High-resolution Elastographic Assessment of the Optic Nerve Head

视神经乳头的高分辨率弹性成像评估

基本信息

  • 批准号:
    9900001
  • 负责人:
  • 金额:
    $ 64.08万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-04-01 至 2022-03-31
  • 项目状态:
    已结题

项目摘要

Abstract Glaucoma is a leading cause of irreversible blindness worldwide, affecting over 2.2 million Americans. With an aging population, it is estimated that by 2020 the number of people suffering glaucoma will reach 80 million worldwide, with 11 bilaterally blind. The goal of this study is to develop a novel tool for imaging and measuring elastic properties of the optic nerve head (ONH) and lamina cribrosa (LC) non-invasively. To address this goal, we propose to use phase-resolved OCT to detect small displacements induced by acoustic radiation force (ARF) in the ONH. We further propose to build a novel single crystal 2D array operating in the 4~10 MHz range to generate the ARF pushing force. We propose to use single crystal ultrasound transducers for increased sensitivity. The combined system will enable us to generate images depicting local displacements with nanometer resolution. Using state-of-the-art numerical models this data will be integrated with the complex tissue macro and microstructure to determine the anisotropic, inhomogeneous elastic properties of the tissues of the ONH with high resolution and sensitivity. This will allow us to characterize in detail the association between age, race and gender on the mechanical properties of the tissues of the ONH. Our Specific Aims are: Specific Aim 1: Develop single crystal 2D ultrasound array for ARF pushing force generation. Specific Aim 2: Develop an integrated 2D array ARF-Optical coherence elastography (OCE) system that enables coregistered OCT, US, and ARF-OCE imaging. Specific Aim 3: Develop and validate numerical models that integrate the experimental data from Aims 1 and 2 to determine the local mechanical properties of the LC and ONH. Specific Aim 4: Conduct ex-vivo elastography of human cadaveric and rabbit eyes to establish the capability and assess the performance of the ARF-OCE system to detect changes in ONH and LC tissue properties associated with age, gender and species. In human eyes, we will also determine differences due to race or disease and between regions of the ONH. Specific Aim 5: Demonstrate preclinical imaging capability with in-vivo imaging of LC and ONH in rabbit eyes using ARF-OCE system and optimize system for in-vivo imaging.
摘要

项目成果

期刊论文数量(0)
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ZHONGPING CHEN其他文献

ZHONGPING CHEN的其他文献

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{{ truncateString('ZHONGPING CHEN', 18)}}的其他基金

Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA Endoscopy
通过多功能 OCT/OCTA 内窥镜持续监测和管理阴道健康
  • 批准号:
    10297772
  • 财政年份:
    2021
  • 资助金额:
    $ 64.08万
  • 项目类别:
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology
使用相位分辨光学成像技术对纤毛跳动动力学进行体内成像和量化
  • 批准号:
    10201599
  • 财政年份:
    2020
  • 资助金额:
    $ 64.08万
  • 项目类别:
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology
使用相位分辨光学成像技术对纤毛跳动动力学进行体内成像和量化
  • 批准号:
    10033635
  • 财政年份:
    2020
  • 资助金额:
    $ 64.08万
  • 项目类别:
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology
使用相位分辨光学成像技术对纤毛跳动动力学进行体内成像和量化
  • 批准号:
    10381672
  • 财政年份:
    2020
  • 资助金额:
    $ 64.08万
  • 项目类别:
High-resolution Elastographic Assessment of the Optic Nerve Head
视神经乳头的高分辨率弹性成像评估
  • 批准号:
    10162604
  • 财政年份:
    2018
  • 资助金额:
    $ 64.08万
  • 项目类别:
Combined OCT/US/PAT system for intravascular Imaging
用于血管内成像的组合 OCT/US/PAT 系统
  • 批准号:
    9259809
  • 财政年份:
    2015
  • 资助金额:
    $ 64.08万
  • 项目类别:
Combined OCT/US/PAT system for intravascular Imaging
用于血管内成像的组合 OCT/US/PAT 系统
  • 批准号:
    9042035
  • 财政年份:
    2015
  • 资助金额:
    $ 64.08万
  • 项目类别:
Combined OCT/US/PAT system for intravascular Imaging
用于血管内成像的组合 OCT/US/PAT 系统
  • 批准号:
    8871465
  • 财政年份:
    2015
  • 资助金额:
    $ 64.08万
  • 项目类别:
Phase resolved ARF optical coherence elastography for intravascular imaging
用于血管内成像的相分辨 ARF 光学相干弹性成像
  • 批准号:
    9061010
  • 财政年份:
    2014
  • 资助金额:
    $ 64.08万
  • 项目类别:
Phase resolved ARF optical coherence elastography for intravascular imaging
用于血管内成像的相分辨 ARF 光学相干弹性成像
  • 批准号:
    10670744
  • 财政年份:
    2014
  • 资助金额:
    $ 64.08万
  • 项目类别:

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