Data Management and Portal for the INCLUDE (DAPI) Project
INCLUDE (DAPI) 项目的数据管理和门户
基本信息
- 批准号:10697338
- 负责人:
- 金额:$ 386.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-26 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAdvocacyAdvocateAffectAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmyloid Beta A4 Precursor ProteinAreaAutoimmune DiseasesAutomobile DrivingBiomedical ResearchChildChromosome 21ChromosomesClinicClinicalCohort StudiesCollaborationsCommunitiesComplexDataData Coordinating CenterData SetDevelopmentDisciplineDiseaseDown SyndromeEcosystemEducationEnsureEnvironmental Risk FactorEpigenetic ProcessEpilepsyFamilyGeneral PopulationGenetic DiseasesGenetic VariationGoalsGovernmentGovernment OfficialsHumanHuman BiologyIndividualIntuitionInvestigationLife Cycle StagesLife ExpectancyLinkLongevityMalignant NeoplasmsMethodsMissionModalityMultiomic DataNeurologicParticipantPathogenicityPersonsPhenotypePhysiciansPopulationProteomeQuality of lifeResearchResourcesRiskSchoolsScientistSocietiesSolidSurveysTechnologyTimeTrainingUnited States National Institutes of HealthVariantautism spectrum disorderbench to bedsidebiobankcomorbiditycongenital heart disorderdata accessdata ecosystemdata integrationdata managementdata portaldata resourcedata sharingdata sharing networksdesigndiverse dataempowermentepidemiology studyevidence baseinnovationinteroperabilityleukemialifestyle factorsmetabolomemicrobiomenovelnovel diagnosticsnovel therapeuticsoutreachprecision medicineprenatalsynergismtimelinetooltranscriptomevirtual
项目摘要
PROJECT SUMMARY – Overall.
Individuals with Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), are predisposed to a
spectrum of heterogeneous diseases while simultaneously protected from developing other pathogenic
conditions relative to the typical population. In ways still poorly defined, T21 protects individuals from most solid
malignancies while strongly predisposing them to Alzheimer’s disease, congenital heart disease, leukemias,
autoimmune disorders, and diverse neurological conditions. However, little is known about the mechanisms
underlying this differential clinical profile or the relationship between these conditions in the context of DS versus
when occurring in the general population. Moreover, individuals with DS display a large degree of phenotypic
variation suggesting the existence of modulating factors that affect how T21 manifests at the individual level,
including genetic variation, epigenetic modifiers, varying endotypes modulating the transcriptome, proteome and
metabolome, lifestyle and environmental factors, or even perhaps the microbiome. Therefore, elucidating the
mechanisms driving and modulating DS comorbidities will serve not only the six million people worldwide with
DS alive today, but also millions of individuals affected by these comorbidities in the typical population. The
importance of this fact has been acknowledged by NIH through the launching of the INCLUDE (INvestigation of
Co-occurring conditions across the Lifespan to Understand Down syndromE) Project.
Within this framework, the INCLUDE Project has recognized the strategic importance of a large cohort study of
individuals with DS to accelerate research in this area, with the goal of enabling a precision medicine approach
to DS via novel diagnostics and therapeutic tools. Therefore, the mission of this DCC team is to create a world-
class resource and associated platforms for empowered data sharing, data access, and integrative analysis that
will enable novel investigations into all DS comorbidities across the lifespan. To achieve this goal, the proposed
DCC will create a real-time, integrated data ecosystem that will catalyze innovation, collaboration, and
transformative discoveries by engaging and empowering a diverse community of stakeholders to drive
collaborative, accelerated discovery on behalf of transformative action and impact from bench to bedside and
beyond. Altogether, the efforts underpinning the proposed efforts will serve first and foremost people with DS
by accelerating research into DS comorbidities, but will also elevate our understanding of human biology across
diverse scientific disciplines.
项目总结-总体。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert J Carroll其他文献
Robert J Carroll的其他文献
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{{ truncateString('Robert J Carroll', 18)}}的其他基金
AnVIL Clinical Environment for Innovation and Translation (ACE-IT)
AnVIL 创新与转化临床环境 (ACE-IT)
- 批准号:
10747551 - 财政年份:2023
- 资助金额:
$ 386.95万 - 项目类别:
Advancing Image Data Interoperability and Standards within an NIH Ecosystem (AIDISNE): A CHOP, FlyWheel, and Seven Bridges Integration Demonstration Project
推进 NIH 生态系统 (AIDISNE) 内的图像数据互操作性和标准:CHOP、FlyWheel 和七桥集成示范项目
- 批准号:
10690302 - 财政年份:2020
- 资助金额:
$ 386.95万 - 项目类别:
Data Management and Portal for the INCLUDE (DAPI) Project
INCLUDE (DAPI) 项目的数据管理和门户
- 批准号:
10264912 - 财政年份:2020
- 资助金额:
$ 386.95万 - 项目类别:
User-ready tools and scalable workflows for INCLUDE datasets in the cloud: advancing brain imaging data management and analytics
用于云中 INCLUDE 数据集的用户就绪工具和可扩展工作流程:推进脑成像数据管理和分析
- 批准号:
10406678 - 财政年份:2020
- 资助金额:
$ 386.95万 - 项目类别:
Data Management and Portal for the INCLUDE (DAPI) Project
INCLUDE (DAPI) 项目的数据管理和门户
- 批准号:
10472037 - 财政年份:2020
- 资助金额:
$ 386.95万 - 项目类别:
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