The AnVIL Data Ecosystem

AnVIL 数据生态系统

• 批准号: 10222996
• 负责人: Robert J Carroll
• 金额: $ 50万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10222996
• 关键词: Adopted; Bioconductor; Data; Data Analyses; Data Set; Development; Ecosystem; Ensure; Future; Galaxy; Genome; Genomics; Goals; Ingestion; Link; Patients; Protocols documentation; Research Personnel; Support System; System; Technical Expertise; Time; Work; cost; data access; data ecosystem; data harmonization; data sharing; improved; interoperability; large scale data; symposium

Project Summary In working to achieve the long-term goal of the AnVIL of providing a unified platform for ingestion and organization for a multitude of current and future genomic and genome-related datasets, it is clear that enabling the cross-talk of multiple platforms and datasets is a critical barrier. To overcome this challenge, we propose to improve, adopt, and implement shared standards for DRS and RAS within the Terra platform. To do that, we propose the following aims and subaims: 1. Enhance cross-system interoperability through development and implementation of standards for authentication and for sharing data and applications 1.1 Interoperability standards and technical requirements: Improve interoperability standards, scope technical work needed to support these standards, and develop conventions across systems to facilitate the realization of these use cases 1.2 Terra DRS and RAS support:  Ensure GA4GH DRS 1.1 support. Data should be accessible over the protocol supporting the systems described in the interoperability use cases. DRS 1.1 is the latest version of the GA4GH standard and includes GUID support  Include RAS account linking and token management  Ensure PFB search handoff support improvements as the convention is refined  Ensure Leonardo accommodates DRS 1.1 and RAS support 1.3 Galaxy and R / Bioconductor DRS and RAS support:  Ensure GA4GH DRS 1.1 support in Galaxy and R / Bioconductor, so data can be accessed using that standard  Include RAS token sharing with Galaxy and RStudio instances in Terra, allowing Galaxy and R / Bioconductor to access DRS accessible data using RAS credentials 2. Complete the scoping required to integrate RAS support into the Data Use Oversight System (DUOS) 2.1 Complete scoping to add support to DUOS to enable data access committees to issue visas to researchers

项目摘要 在努力实现AnVIL的长期目标，即提供一个统一的摄取和 组织大量当前和未来的基因组和基因组相关的数据集，很明显， 实现多个平台和数据集的串扰是一个关键的障碍。为了克服这一挑战，我们 建议在Terra平台内改进、采用和实施DRS和RAS的共享标准。做 为此，我们提出以下目标和次级目标： 1.通过制定和实施标准， 身份验证以及共享数据和应用程序 1.1互操作性标准和技术要求：改进互操作性标准、范围 支持这些标准所需的技术工作，并制定跨系统的约定， 促进这些用例的实现 1.2 Terra DRS和RAS支持： 确保GA 4GH DRS 1.1支持。数据应可通过方案访问， 互操作性用例中描述的系统。DRS 1.1是 GA 4GH标准，并包括对USB的支持 包括RAS帐户链接和令牌管理 确保PFB搜索切换支持随着约定的完善而改进 确保列奥纳多适应DRS 1.1和RAS支持 1.3 Galaxy和R / Bioconductor DRS和RAS支持： 确保Galaxy和R / Bioconductor支持GA 4GH DRS 1.1，以便可以访问数据 用这个标准 在Terra中与Galaxy和RStudio实例共享RAS令牌，允许Galaxy和 R / Bioconductor使用RAS凭证访问DRS可访问数据 2.完成将RAS支持集成到数据使用监督系统（DUOS）中所需的范围界定 2.1完成范围界定，以增加对DUOS的支持，使数据访问委员会能够签发签证， 研究人员