The AnVIL Data Ecosystem

项目摘要 铁锤环境使用领先的云级网络基础设施作为基础，支持 NHGRI研究人员审查的广泛使用的分析环境和框架。这个项目的总体目标是 ODSS补充建议是为了增强用户体验，增加互操作性、数据访问和 共享和数据可见性。为了实现这些目标，我们提出了七个目标，每个目标都涉及到各个组成部分 数据访问、可共享性和可见性。综合起来，所有AIMS都将显著改善用户体验 在铁砧上。目标1.FHIR工作：以应对在以下方面搜索和交换数据的挑战 生物医学研究系统，我们正在扩大与杉木的工作，包括创建一个砧木冷杉应用程序和 支持FHIR的单用户租户，让用户可以轻松地将他们的电子病历数据加载到铁砧中。目标2.将Terra作为 GA4GH Passport Broker：为了现代化和扩展数据访问权限，铁锤将利用 RAS的权威性和标准化。此外，使Terra成为GA4GH护照经纪公司，我们将Access 通过白名单、DBGaP授权和其他护照代理进行控制，以极大地改进数据访问 控制力。目标3.Terra支持DRS1.x作为服务器：努力提高Anvil的装载能力 并使用其他合作伙伴内部的数据，我们将继续扩大在Terra的DRS支持。这项工作使铁锤对齐 在值得信赖的合作伙伴的更大生态系统中。目标4.NCPI门户和数据集索引：扩展数据 可见性，NCPI数据集目录将构建一个自动机制来直接与平台交互 允许查询和检索研究信息及相关元数据的API。直接访问 平台的FHIR服务器将减少人工工作量，从而提高数据的质量和及时性。 目标5.实现跨平台应用程序的标准化：简化复杂应用程序在 因此，Anvil将扩展在中创建的应用程序标准化 具有Kubernetes支持的BioData催化剂，显著提高了砧座的灵活性和可扩展性 站台。目标6.FHIR Codeathon：努力吸引NCPI平台和科学界成员 在开发利用FHIR表示的研究数据和API的工具时，我们将托管一系列虚拟 杉木代码-a-thons目标7.NIH Duos试点扩展：为了解决可伸缩性挑战，铁锤将 将DUOS试点计划扩展到五个新的小组，使我们能够收集关于DUOS的定性信息 扩大试点，促进数据访问委员会使用和采用DUO。

Project Summary The AnVIL environment uses leading cloud-scale cyberinfrastructure as the foundation supporting the most widely-used analysis environments and frameworks vetted by NHGRI researchers. The overall goals of this ODSS supplement proposal are to enhance the user experience and increase interoperability, data access and sharing, and data visibility. To accomplish these objectives, we propose seven aims, each tackling components of data access, shareability, and visibility. In combination, all aims will significantly improve the user experience in AnVIL. Aim 1. FHIR work: In order to address challenges in searching and exchanging data across biomedical research systems, we are expanding work with FHIR to include creating an AnVIL FHIR app and stand up single user tenants for FHIR for users to easily load their EMR data into AnVIL. Aim 2. Terra as a GA4GH Passport Broker: To modernize and expand data access permissions, the AnVIL will harness the power and standardization of RAS. Further, enabling Terra as a GA4GH passport broker, we combine access control through whitelists, dbGaP authorizations, and other passport brokers to greatly improve data access control. Aim 3. Terra supporting DRS 1.x as a server: In an effort to improve AnVIL’s capacity to onboard and use data within other partners, we will continue expansion of DRS support in Terra. This work aligns AnVIL in the larger ecosystem of trusted partners. Aim 4. NCPI Portal and Dataset indexing: To expand data visibility, the NCPI Dataset Catalog will build an automated mechanism to interface directly with the platform APIs to allow querying and to retrieve the study information and associated metadata. Direct access to the platform's FHIR server will reduce the manual effort and hence improve the quality and timeliness of the data. Aim 5. Standardization of "apps" across Platforms: To ease deployment of complex applications within AnVIL thereby moving toward a comprehensive platform, AnVIL will extend the app standardization created in BioData Catalyst with the Kubernetes support to dramatically increase flexibility and extensibility of the AnVIL platform. Aim 6. FHIR Codeathon: In an effort to engage NCPI platforms and scientific community members in developing tools that leverage FHIR-represented research data and APIs, we will host a series of Virtuaal FHIR Code-a-thons. Aim 7. NIH DUOS Pilot Expansion: To address scalability challenges, the AnVIL will extend the DUOS pilot program to five new groups allowing us to pull together qualitative information on DUOS pilot expansion that will promote the use and adoption of DUOS by Data Access Committees.