The AnVIL Data Ecosystem

AnVIL 数据生态系统

• 批准号: 10166400
• 负责人: Robert J Carroll
• 金额: $ 21.72万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-19 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166400
• 关键词: 2019-nCoV; Award; Biology; COVID-19; COVID-19 pandemic; Certification; Clinical; Communities; Consent; Data; Data Analyses; Data Reporting; Data Set; Development; Disease; Ensure; Environment; Ethics; Fostering; Funding; Generations; Genetic; Genetic Determinism; Genetic Research; Genome; Genomics; Genotype; Goals; Grant; Growth; Guidelines; Human Genetics; Individual; Infection; Ingestion; Intake; Knowledge; Lead; Learning; Libraries; Metadata; Methods; Mission; National Human Genome Research Institute; Outcome; Parents; Patients; Pharmaceutical Preparations; Phenotype; Predisposition; Preparation; Procedures; Process; Protocols documentation; Questionnaires; Reaction Time; Research; Research Design; Research Personnel; Resource Sharing; Risk; Role; Sampling; Severities; System; Technology; Time; United States; Work; data access; data dissemination; data ecosystem; data ingestion; data sharing; data standards; data warehouse; experience; improved; member; parent grant; response

PROJECT SUMMARY In response to the COVID-19 pandemic, the Host Genetics Initiative (HGI) has formed to generate, share, and analyze data to identify the underlying genetic determinants of the SARS-CoV-2 infection and disease, including the severity in symptomatic presentation and associated outcomes, as well as the development of hypotheses for drug repurposing. To achieve the aims of the consortium, the need for a mechanism to ingest data and make it broadly available for researchers arose. With the National Human Genome Research Institute’s commitment to the same goals, the AnVIL, which is predicated on providing a cloud environment for the analysis of large genomic and clinical datasets, became the eminent choice to serve as a data repository and analysis platform for the consortium. As the technology has been developed through the parent grant, the aims proposed for this grant allows the AnVIL to provide scalable support for the Host Genetics Initiative in their utilization of the AnVIL. The specific aims include: • Aim 1: Scale the data Ingest processes for genotypic, phenotypic, clinical report data and metadata to support the expected influx of data from the Host Genetics Initiative • Aim 2: Utilize the Data Use Oversight System (DUOS) to facilitate expeditious data governance and access requests • Aim 3: Dissemination of data for researchers via featured workspaces done in partnership with the Host Genetics Initiative • Aim 4: Provide support for new data generator and user communities Through the implementation of these aims over the course of one year, we will enable the data that is generated by the members of the Host Genetics Initiative to be broadly shared and analyzed with researchers inside and outside of the consortium, which will serve to contribute to the global knowledge of the biology of SARS-CoV-2 infection and disease.

项目摘要 为了应对COVID-19大流行，宿主遗传学倡议（HGI）已经形成，以产生，分享， 分析数据以确定SARS-CoV-2感染和疾病的潜在遗传决定因素， 包括症状表现的严重程度和相关结局，以及 药物再利用的假设为了实现财团的目标，需要一种机制， 数据，并使其广泛提供给研究人员出现。国家人类基因组研究 该研究所致力于实现相同的目标，即AnVIL，其前提是为 大型基因组和临床数据集的分析，成为作为数据存储库的杰出选择 和分析平台。由于这项技术是通过母公司赠款开发的， 为这笔赠款提出的目标允许AnVIL为宿主遗传学倡议提供可扩展的支持， 他们对Anvil的利用。具体目标包括： ·目标1：将基因型、表型、临床报告数据和元数据的数据摄取过程扩展到 支持来自宿主遗传学倡议的预期数据流入 目标2：利用数据使用监督系统（DUOS）促进快速的数据治理， 访问请求 ·目标3：通过与联合国开发计划署合作完成的专题研究，为研究人员传播数据。 宿主遗传学倡议 目标4：为新的数据生成者和用户社区提供支持 通过在一年的时间里实现这些目标，我们将能够获得 由宿主遗传学倡议的成员产生，与研究人员广泛分享和分析， 该联盟的内部和外部，这将有助于促进全球的生物学知识， SARS-CoV-2感染与疾病