The AnVIL Data Ecosystem

项目总结 为了应对新冠肺炎大流行，宿主遗传学倡议(HGI)已经形成，以产生、分享和 分析数据以确定SARS-CoV-2感染和疾病的潜在遗传决定因素， 包括症状表现的严重性和相关结果，以及 药物再利用的假说。为了实现财团的目标，需要一种机制来摄取 数据，并使其为研究人员广泛可用的兴起。与美国国家人类基因组研究中心 研究所致力于实现相同的目标，这是基于为以下方面提供云环境 对大型基因组和临床数据集的分析成为充当数据存储库的最佳选择 以及财团的分析平台。由于这项技术是通过母公司赠款开发的， 为这笔赠款建议的AIMS允许铁砧为#年的宿主遗传学倡议提供可扩展的支持 他们对铁砧的利用。具体目标包括： ·目标1：扩大基因型别、表型、临床报告数据和元数据的数据摄取流程，以 支持来自宿主遗传学计划的预期数据涌入 ·目标2：利用数据使用监督系统(DUOS)促进快速数据治理和 访问请求 ·目标3：通过与联合国开发计划署合作开展的专题工作区为研究人员传播数据 宿主遗传学倡议 ·目标4：为新的数据生成器和用户社区提供支持 通过在一年的时间内实施这些目标，我们将使数据能够 由宿主遗传学倡议成员产生，与研究人员广泛分享和分析 财团内部和外部，这将有助于促进全球对生物的认识 SARS-CoV-2感染与疾病。

PROJECT SUMMARY In response to the COVID-19 pandemic, the Host Genetics Initiative (HGI) has formed to generate, share, and analyze data to identify the underlying genetic determinants of the SARS-CoV-2 infection and disease, including the severity in symptomatic presentation and associated outcomes, as well as the development of hypotheses for drug repurposing. To achieve the aims of the consortium, the need for a mechanism to ingest data and make it broadly available for researchers arose. With the National Human Genome Research Institute’s commitment to the same goals, the AnVIL, which is predicated on providing a cloud environment for the analysis of large genomic and clinical datasets, became the eminent choice to serve as a data repository and analysis platform for the consortium. As the technology has been developed through the parent grant, the aims proposed for this grant allows the AnVIL to provide scalable support for the Host Genetics Initiative in their utilization of the AnVIL. The specific aims include: • Aim 1: Scale the data Ingest processes for genotypic, phenotypic, clinical report data and metadata to support the expected influx of data from the Host Genetics Initiative • Aim 2: Utilize the Data Use Oversight System (DUOS) to facilitate expeditious data governance and access requests • Aim 3: Dissemination of data for researchers via featured workspaces done in partnership with the Host Genetics Initiative • Aim 4: Provide support for new data generator and user communities Through the implementation of these aims over the course of one year, we will enable the data that is generated by the members of the Host Genetics Initiative to be broadly shared and analyzed with researchers inside and outside of the consortium, which will serve to contribute to the global knowledge of the biology of SARS-CoV-2 infection and disease.