Lifestyle & Behaviors Core, Vos

生活方式

• 批准号: 10260486
• 负责人: MIRIAM B. VOS
• 金额: $ 10.97万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260486
• 关键词: Adult; Area; Awareness; Behavior; Behavior assessment; Biological Process; Cardiopulmonary; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Collaborations; Collection; Communities; Community Surveys; Consultations; Cystic Fibrosis; Data; Data Analyses; Data Collection; Databases; Diet; Dietary Assessment; Dietary intake; Evaluation; Exercise; Exercise Test; Exercise Tolerance; Experimental Designs; Family; Foundations; Funding; Future; Gases; Goals; Health; Home; Inpatients; Interdisciplinary Study; International; Knowledge; Life; Life Style; Literature; Longevity; Lung diseases; Lung infections; Medical; Metabolic; Methodology; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Outpatients; Performance; Phenotype; Physical activity; Positioning Attribute; Protocols documentation; Quality of life; Research; Research Personnel; Role; Services; Sleep; Surveys; Survival Rate; Testing; Therapeutic Intervention; Training; Translating; Translational Research; Translations; Voice; actigraphy; base; behavior change; behavior measurement; behavioral outcome; biobehavior; clinical investigation; comorbidity; cystic fibrosis patients; cystic fibrosis related diabetes; data dissemination; data warehouse; diet and exercise; exercise capacity; instrument; interest; mortality; neglect; novel; peer; poor sleep; pulmonary function; ranpirnase; sleep behavior; tool; training project

PROJECT SUMMARY – Core 3: Lifestyle and Behaviors Core There have been considerable advances in research and medical therapies for cystic fibrosis (CF); however, therapeutic interventions for non-pulmonary, systemic manifestations have been neglected. Fortunately, the median survival rate in CF is on the rise. Therefore, a paradigm shift to focus on modifiable lifestyle and behavioral outcomes that will enable long-term quality of life in CF is critically needed. Individuals with CF are less physically active than their peers and lower exercise capacity is associated with greater mortality, steeper decline in pulmonary function, and more pulmonary infections. Sleep is an essential, restorative, biologic process crucial for maintaining and optimizing health. Poor sleep in CF has not only been associated with progressive lung disease, but also reduced quality of life and daytime performance. Diet has long been a cornerstone of CF therapy; however, diet quality has not been a focus and its role within the changing landscape of CF or its effects on co-morbidities (such as CF-related diabetes) and long-term health are unknown. The overall goal of the Lifestyle & Behaviors Core (LBC) within the Georgia CF Core Center is to bring advanced methodologies to CF-focused research and to accelerate translational, bio-behavioral research comprised of exercise, physical activity, diet, and sleep outcomes in people with CF. This Core will fill a critical knowledge gap by increasing awareness, educating and disseminating knowledge, and supporting the integration of important lifestyle and behavioral measurements and outcomes into clinical investigations across the lifespan. This will be accomplished by three Aims, as follows: Aim 1. To provide training, project-specific consultation and support for assessing, collecting, and interpreting exercise, physical activity, diet, sleep and behavior change data in CF studies. Aim 2. To enhance the utilization and integration of instruments and tools related to lifestyle and behaviors into clinical and translational research in children and adults with CF. Aim 3. To incorporate extensive phenotyping of lifestyle and behavior outcomes into the longitudinal Georgia CF Data Warehouse hosted by the Core Center. The proposed LBC is unique among the currently funded P30 CF Centers. Successful implementation of this core will enable Center Investigators to undertake research to focus on the interaction of lifestyle and behavioral outcomes that are essential for the control of CF related diabetes, the primary focus of this P30 application, and other comorbidities and conditions within the mission of the NIDDK.

项目摘要-核心3：生活方式和行为核心 囊性纤维化(CF)的研究和医学治疗已有相当大的进步； 然而，针对非肺源性、全身性症状的治疗干预一直被忽视。 幸运的是，CF的中位存活率正在上升。因此，将重点放在范式转变上 可改变的生活方式和行为结果将使CF的长期生活质量成为可能 这是急需的。与同龄人相比，患有CF的人体力活动较少，运动量也较少 容量与更高的死亡率、肺功能的急剧下降以及更多 肺部感染。睡眠是一种基本的、恢复性的生物过程，对维持和恢复睡眠至关重要 优化健康。慢性阻塞性肺疾病患者睡眠不佳不仅与进行性肺部疾病有关，而且 也降低了生活质量和白天的表现。饮食一直是CF治疗的基石； 然而，饮食质量并不是一个关注的焦点，它在不断变化的CF格局中的作用或其影响 关于合并症(如与慢性纤维性心脏病相关的糖尿病)和长期健康状况尚不清楚。总目标 佐治亚州CF核心中心内的生活方式和行为核心(LBC)将带来先进的 以CF为重点的研究方法，并加快翻译、生物行为研究 包括运动、体力活动、饮食和CF患者的睡眠结果。这个核心将填满 通过提高认识、教育和传播知识来消除严重的知识差距，以及 支持将重要的生活方式和行为测量及结果纳入 在整个生命周期内进行临床研究。这将通过三个目标来实现，具体如下： 目标1.提供培训、具体项目咨询和支助，以评估、收集、 并解释了CF研究中的锻炼、体力活动、饮食、睡眠和行为变化数据。 目标2.加强与生活方式和生活方式有关的手段和工具的利用和整合 将儿童和成人的行为纳入临床和翻译研究。 目标3.将生活方式和行为结果的广泛表型纳入 由核心中心托管的纵向佐治亚州CF数据仓库。 拟议的LBC在目前资助的P30 CF中心中是独一无二的。成功实施 这一核心将使中心的研究人员能够进行研究，专注于生活方式的相互作用 和行为结果对于控制CF相关的糖尿病至关重要，主要关注的是 这项P30申请，以及NIDDK任务范围内的其他并发症和条件。