Lifestyle & Behaviors Core, Vos

项目概要-核心3：生活方式和行为核心 囊性纤维化（CF）的研究和医学治疗已经取得了相当大的进展; 然而，对非肺部、全身性表现的治疗干预一直被忽视。 幸运的是，CF的中位生存率正在上升。因此，一个范式的转变， 可改变的生活方式和行为结果，使CF的长期生活质量， 急需的。CF患者的身体活动量低于同龄人， 容量与更高的死亡率、肺功能的急剧下降等相关， 肺部感染睡眠是一个必不可少的、恢复性的生物过程， 优化健康。CF患者睡眠不佳不仅与进行性肺病有关， 也降低了生活质量和日间表现。饮食一直是CF治疗的基石; 然而，饮食质量并没有成为关注的焦点，它在不断变化的CF景观中的作用及其影响 对合并症（如CF相关糖尿病）和长期健康的影响尚不清楚。总目标 格鲁吉亚CF核心中心内的生活方式和行为核心（LBC）将带来先进的 方法，以CF为重点的研究，并加快转化，生物行为研究 包括CF患者的运动、体力活动、饮食和睡眠结果。这一核心将填补 通过提高认识、教育和传播知识，消除严重的知识差距， 支持将重要的生活方式和行为测量和结果整合到 整个生命周期的临床研究。这将通过以下三个目标来实现： 目标1.提供培训、项目咨询和支持，以评估、收集、 并解释CF研究中的运动、身体活动、饮食、睡眠和行为变化数据。 目标二。加强对与生活方式有关的文书和工具的利用和整合， 行为纳入儿童和成人CF的临床和转化研究。 目标3.将生活方式和行为结果的广泛表型纳入 由核心中心托管的纵向格鲁吉亚CF数据仓库。 拟议的LBC在目前资助的P30 CF中心中是独一无二的。成功实施 这一核心将使中心研究人员能够开展研究，重点关注生活方式的相互作用， 和行为结果，这是必不可少的CF相关糖尿病的控制， 该P30应用程序以及NIDDK使命中的其他合并症和条件。

PROJECT SUMMARY – Core 3: Lifestyle and Behaviors Core There have been considerable advances in research and medical therapies for cystic fibrosis (CF); however, therapeutic interventions for non-pulmonary, systemic manifestations have been neglected. Fortunately, the median survival rate in CF is on the rise. Therefore, a paradigm shift to focus on modifiable lifestyle and behavioral outcomes that will enable long-term quality of life in CF is critically needed. Individuals with CF are less physically active than their peers and lower exercise capacity is associated with greater mortality, steeper decline in pulmonary function, and more pulmonary infections. Sleep is an essential, restorative, biologic process crucial for maintaining and optimizing health. Poor sleep in CF has not only been associated with progressive lung disease, but also reduced quality of life and daytime performance. Diet has long been a cornerstone of CF therapy; however, diet quality has not been a focus and its role within the changing landscape of CF or its effects on co-morbidities (such as CF-related diabetes) and long-term health are unknown. The overall goal of the Lifestyle & Behaviors Core (LBC) within the Georgia CF Core Center is to bring advanced methodologies to CF-focused research and to accelerate translational, bio-behavioral research comprised of exercise, physical activity, diet, and sleep outcomes in people with CF. This Core will fill a critical knowledge gap by increasing awareness, educating and disseminating knowledge, and supporting the integration of important lifestyle and behavioral measurements and outcomes into clinical investigations across the lifespan. This will be accomplished by three Aims, as follows: Aim 1. To provide training, project-specific consultation and support for assessing, collecting, and interpreting exercise, physical activity, diet, sleep and behavior change data in CF studies. Aim 2. To enhance the utilization and integration of instruments and tools related to lifestyle and behaviors into clinical and translational research in children and adults with CF. Aim 3. To incorporate extensive phenotyping of lifestyle and behavior outcomes into the longitudinal Georgia CF Data Warehouse hosted by the Core Center. The proposed LBC is unique among the currently funded P30 CF Centers. Successful implementation of this core will enable Center Investigators to undertake research to focus on the interaction of lifestyle and behavioral outcomes that are essential for the control of CF related diabetes, the primary focus of this P30 application, and other comorbidities and conditions within the mission of the NIDDK.