STOPNASH Meeting

停止会议

• 批准号: 8986466
• 负责人: MIRIAM B. VOS
• 金额: $ 2万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8986466
• 关键词: Address; Adipocytes; Adult; Affect; American; Area; Attention; Cardiology; Cardiovascular Diseases; Child; Childhood; Clinical; Collaborations; Communities; Consensus; Diagnosis; Disease; District of Columbia; Endocrinologist; Endocrinology; Environment; Epidemic; Family; Fibrosis; Functional disorder; Gastroenterology; Health; Hepatocyte; Hepatology; Hispanics; Incidence; Inflammation; Insulin Resistance; Knowledge; Lead; Lipids; Liver; Liver diseases; Metabolic; Metabolism; Mission; Names; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Onset of illness; Outcome; Participant; Pathway interactions; Patients; Pattern; Population; Prevalence; Prevention; Public Health; Research; Research Personnel; Science; Scientist; Societies; Staging; Time; Training; United States; Washington; Woman; Work; chronic liver disease; design; diabetes risk; disorder prevention; experience; high risk; improved; interest; meetings; non-alcoholic fatty liver; nonalcoholic steatohepatitis; nutrition; programs; public health relevance; symposium

 DESCRIPTION (provided by applicant): Nonalcoholic fatty liver disease is a chronic liver disease that affects an estimated 10% of the US population including 7 million children. The latest studies on prevalence suggest that the incidence of NAFLD is still rising despite the slowing of the obesity epidemic. Children and adults with NAFLD are at high risk of progressing to end stage liver disease over time and the pathophysiology of NAFLD appears to dramatically increase the risk of diabetes and cardiovascular disease. Because of this and the whole body metabolic dysregulation associated with NAFLD, the research on NAFLD is progressing in many different areas including by pediatric hepatologists, endocrinologists, cardiology, metabolism experts, nutrition scientists, experts in insulin resistance, hepatocyte functions, and adipocyte effects to name just a few. The global aims of this symposium is to bring together experts from diverse fields to move NAFLD research forward, to develop consensus regarding priorities in NAFLD research and to encourage young investigators and investigators from diverse backgrounds to study NAFLD. In order to accomplish these important aims, the "STOPNASH: Symposium on The Origins and Pathways of NASH: Is it Preventable?" one day symposium will be held on October 7th, 2015 at the Washington Hilton, Washington DC in conjunction with the annual meeting of the North American Society of Pediatric Hepatology, Gastroenterology and Nutrition. The overarching theme of this research conference is "what causes the initiation of NASH?" There will be five modules including 1) Clinical patterns informing pathophysiology 2) Systemic metabolic dysregulation associated with NASH 3) Initiation mechanisms of inflammation and fibrosis 4) Research informing prevention and 5) Future research priorities. There will be breakout sessions to promote discussion amongst the researchers and to generate consensus on the most important gaps in research knowledge. Of the 20 experts invited to speak, 8 are women, 2 are Hispanic, and 4 are young investigators. Moderators include 5 young investigators, 3 Hispanic investigators and 50% women. Trainees and young investigators attending will be encouraged to participate in the break-out sessions to discuss research gaps and opportunities. The symposium focuses on a research area that has not been addressed previously in a conference of this type and will provide an excellent training environment for junior investigators interested in pursuing research in NAFLD. We anticipate 150 or more attendees to participate in this unique symposium designed to catalyze the field of NAFLD research, particularly in the area of the onset of the disease. This is expected to lead to synergistic collaborations advancing knowledge to improve outcomes for patients diagnosed with NAFLD in childhood and eventually to promote effective prevention of the disease.

 描述（由申请人提供）： 非酒精性脂肪肝是一种慢性肝病，估计影响10%的美国人口，包括700万儿童。关于患病率的最新研究表明，尽管肥胖流行放缓，但NAFLD的发病率仍在上升。随着时间的推移，NAFLD儿童和成人进展为终末期肝病的风险很高，NAFLD的病理生理学似乎会显著增加糖尿病和心血管疾病的风险。由于这一点以及与NAFLD相关的全身代谢失调，对NAFLD的研究正在许多不同的领域取得进展，包括儿科肝病学家，内分泌学家，心脏病学，代谢专家，营养科学家，胰岛素抵抗，肝细胞功能和脂肪细胞影响方面的专家，仅举几例。本次研讨会的全球目标是汇集来自不同领域的专家，推动NAFLD研究向前发展，就NAFLD研究的优先事项达成共识，并鼓励来自不同背景的年轻研究人员和研究人员研究NAFLD。为了实现这些重要的目标，“STOPNASH：NASH的起源和途径研讨会：它是否可行？“为期一天的研讨会将于2015年10月7日在华盛顿希尔顿酒店举行，华盛顿DC与北美儿科肝病学，胃肠病学和营养学会年会一起举行。本次研究会议的主题是“什么导致NASH的发生？“将有五个模块，包括1）临床模式通知病理生理学2）与NASH相关的全身代谢失调3）炎症和纤维化的启动机制4）研究通知预防和5）未来的研究重点。将有分组会议，以促进研究人员之间的讨论，并就研究知识中最重要的差距达成共识。在受邀发言的20位专家中，8位是女性，2位是西班牙裔，4位是年轻的研究人员。主持人包括5名年轻研究人员，3名西班牙裔研究人员和50%的女性。将鼓励学员和年轻的研究人员参加分组会议，讨论研究差距和机会。研讨会的重点是一个研究领域，以前没有在这种类型的会议，并将提供一个良好的培训环境，为初级研究人员 有兴趣从事NAFLD的研究。我们预计将有150名或更多的与会者参加这个独特的研讨会，旨在促进NAFLD研究领域，特别是在疾病发作领域。预计这将导致协同合作，促进知识，以改善儿童时期被诊断患有NAFLD的患者的结局，并最终促进疾病的有效预防。