Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement - Clinical Trial Optional)

项目摘要 目前，作为促进少数民族健康和健康差距科学的国家资源，RCMI 协调中心（RCMI-CC）因预算限制而受到限制。因此，从这一资金 竞争性修订将支持临床和转化研究创新活动，这对 一个充满活力的研究网络的运作，致力于获得关于健康原因的新知识 差距，开发可扩展的测量工具，用于研究卫生不公平现象，并实施有效的 采取对文化有敏感认识的干预措施，以减少健康方面的种族和地理差异， 健康公平。 具体目标1。为RCMI临床研究网络开发强大的数据管理系统。 方法：实施安全的基础设施，用于存储和访问研究相关文件， 材料;建立数据管理系统，用于研究数据收集，强调通用数据元素 （CDE）和电子健康记录的统一数据;向RCMI提供方法咨询 研究设计、法规遵从性、生物统计学、数据科学、数据管理和 分析，并促进研究活动的网络协调，包括支持网络指导 以马克思 具体目标2。实施临床研究试点项目计划。 方法：征求，审查和资助博士后研究员和早期阶段提交的合作提案 来自两个或两个以上RCMI受资助机构的研究人员及其RCMI和非RCMI研究导师 这些项目旨在改善少数民族的健康状况，减少健康差距。 具体目标3。促进多RCMI研究。 方法：让RCMI联盟、社区组织、专业协会、联邦 机构或计划，学术和行业合作伙伴，分享培训和教育资源，重点是 减少健康差异;与网络研究中心建立主试验协议，并实施计划， 减少多中心研究的启动时间;为多RCMI研究制定标准操作程序（SOP） 并扩大年度RCMI联盟全国会议的规模和范围。 通过实现这些具体目标，区域海事协调委员会将拥有必要的基础设施， 制定并促进实施严格的机构间临床研究， 健康差距的生物和社会决定因素。此外，预计这将扩大 基础设施将导致研究生产力的提高和赠款的成功。

PROJECT SUMMARY Currently, as the national resource to advance the science of minority health and health disparities, the RCMI Coordinating Center (RCMI-CC) has been hamstrung by budgetary constraints. Thus, funding from this competitive revision will bolster clinical and translational research innovation activities that are vital to the operations of a vibrant research network devoted to gaining new knowledge about the causes of health disparities, developing scalable measurement tools for studying health inequities, and implementing effective and culturally responsive interventions to mitigate ethnic and geographic disparities in health and advance health equity. Specific Aim 1. Develop a Robust Data Management System for the RCMI Clinical Research Network. Approach: Implement a secure infrastructure for storing and providing access to study-related documents and materials; establish a data management system for study data collection emphasizing Common Data Elements (CDEs) and harmonized data from electronic health records; provide methodological consultation to RCMI investigators on study design, regulatory compliance, biostatistics, data science, data management and analysis, and facilitate network coordination of research activities including support for a Network Steering Committee. Specific Aim 2. Implement a Clinical Research Pilot Projects Program. Approach: Solicit, review and fund collaborative proposals submitted by post-doctoral fellows and early-stage investigators from two or more RCMI grantee institutions and their RCMI and non-RCMI mentors on research projects, aimed at improving minority health and reducing health disparities. Specific Aim 3. Facilitate Multi-RCMI Research Studies. Approach: Engage the RCMI Consortium,community-based organizations, professional societies, federal agencies or programs, academic and industry partners, to share training and educational resources focused on reducing health disparities; establish master trial agreements with network study sites and implement plans to reduce start-up for multi-site studies; develop standard operating procedures (SOPs) for multi-RCMI research and expand the size and scope of the annual RCMI Consortium National Conference. By achieving these specific aims, the RCMI-CC will have the necessary infrastructure to foster the development and facilitate the implementation of rigorous inter-institutional clinical research studies on the biological and social determinants of health disparities. Moreover, the expectation is that this expanded infrastructure will result in increased research productivity and heightened grant success.