ASL-3/BSL-3 BIOCONTAINMENT CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 夏威夷作为一个重要的国际港口的地理位置及其与亚洲的战略接近使其成为监测微生物病原体的出现和传播以及调查亚太地区新出现的传染病暴发的天然哨所。一个完全由国家资助的最先进的BSL-3/ABSL-3生物遏制设施现在已经在建造的生物科学大楼中投入使用。作为全州研究人员唯一的此类设施，生物遏制核心是一项宝贵的地区资产，将满足显著扩大的需求和用途。COBRE基金将加强BSL-3/ABSL-3生物遏制核心的基础设施，以支持假说驱动的研究项目，这些项目寻求获得新的知识，以开发更有效的治疗方法和负担得起的预防性疫苗。BSL-3/ABSL-3生物遏制核心由一名高级病毒学家指导，在训练有素的工作人员的协助下，将为研究BSL-3生物遏制下的致病微生物提供新的方法和技术；此外，该核心还将定期提供培训讲习班，并协助核心用户的认证和许可过程。因此，核心的使命将实现服务、研发和教育培训三位一体。 具体目标1.加强对BSL-3/ABSL-3生物遏制的支持和服务。 具体目标2.为BSL-3/ABSL-3微生物病原体的研究开发创新和改进的微生物检测方法。 具体目标3.开发和实施生物遏制相关技术的培训和教育讲习班。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Hawaii's geographic location as a prominent international port and its strategic proximity to Asia makes it a natural sentinel post from which to monitor the emergence and spread of microbial pathogens and to investigate outbreaks of emerging infectious diseases in the Asia-Pacific region. A fully State-financed state-of-the-art BSL-3/ABSL-3 biocontainment facility is now operational in the constructed BioSciences Building. As the only facility of its kind for researchers in the entire State, the Biocontainment Core serves as a valuable regional asset and will meet the significantly expanded needs and usage. COBRE funds will enhance the infrastructure for the BSL-3/ABSL-3 Biocontainment Core, in support of hypothesis-driven research projects that seek to gain new knowledge for the development of more effective treatments and affordable preventive vaccines. Directed by a senior virologist with assistance from a well-trained staff, the BSL-3/ABSL-3 Biocontainment Core will provide opportunities for developing new methods and techniques for studying pathogenic microbes under BSL-3 biocontainment; also, the Core will provide regularly scheduled training workshops and assist in the certification and permitting process for Core users. Thus, the mission of the Core will achieve the triad of service, research and development, and education and training. Specific Aim 1. Enhance support and services in BSL-3/ABSL-3 biocontainment. Specific Aim 2. Develop innovative and improved microbiological assays for research on BSL-3/ABSL-3 microbial pathogens. Specific Aim 3. Develop and implement training and education workshops in biocontainment-related technology.