ACTIVITY 3: TROPICAL INFECTIOUS DISEASES DETECTION AND PREVENTION

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 热带传染病是亚太区域大多数国家面临的最重要的公共卫生问题之一，是发病率和死亡率以及严重经济损失的主要原因。热带传染病检测和预防核心（TIDDPC）是亚太热带医学和传染病研究所（APITMID）的一个组成部分，该研究所提供了急需的额外资源，以帮助建立一个充满活力的临床和转化科学计划，重点是开发改进的诊断测试，快速准确的疾病检测系统，创新的治疗方法，疫苗和其他预防工具和战略。核心假设是，全球化和现代交通，加上亚洲国家的人口和社会变化，将导致更多的病媒传染感染，以及人畜共患病病原体跨越物种，导致疾病爆发日益频繁，有可能大流行蔓延。因此，在热带传染病研究方面建立在UHM的领先地位将为美国大陆新的、新出现的和重新出现的传染病预警哨兵网络提供宝贵的联系。这个由RCMI资助的研究核心的具体目标是：1）开发病原体参考和试剂核心设施，以支持对新出现和重新出现的热带传染病的基础和应用研究; 2）开发分子病理学核心设施，以支持对传染病新检测方法和发病机制的研究;及3）发展微阵列核心设施，以支援与发病机制有关的研究，并协助发展快速检测及发现病原体的技术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Tropical infectious diseases are among the most important public health problems facing most countries in the Asia-Pacific region, and pose a major cause of morbidity and mortality, as well as crippling economic loss. The Tropical Infectious Diseases Detection and Prevention Core (TIDDPC) is an integral component of the Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID), which provides a much-needed additional resource to help build a vigorous clinical and translational science program, focusing on developing improved diagnostic tests, rapid and accurate disease-detection systems, innovative treatments, vaccines and other prevention tools and strategies. The central hypothesis is that globalization and modern transportation, combined with demographic and societal changes in Asian countries, will result in more vector-borne infections, as well as zoonotic disease agents jumping species, causing increasingly frequent outbreaks of diseases having the potential of pandemic spread. Thus, the establishment of research pre-eminence in tropical infectious diseases at UHM would provide a valuable link in an early-warning sentinel network on new, emerging and re-emerging infectious diseases for the continental United States. The specific aims of this RCMI-funded research core are to 1) develop a Pathogen Reference and Reagent Core Facility to support basic and applied research on new, emerging and re-emerging tropical infectious diseases; 2) develop a Molecular Pathology Core Facility to support research on new detection methods and pathogenesis of infectious diseases; and 3) develop a Microarray Core Facility to support pathogenesis-related research and assist in developing rapid pathogen-detection and pathogen-discovery technology.