U HAWAII COBRE: TECHNICAL SUPPORT CORE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标：通过加强指导能力和扩大传染病研究技术支持基础设施的能力，提高研究竞争力。 太平洋新兴传染病研究中心的一个重要组成部分是技术支持核心，它提供特定的服务和优化特定的协议，以促进成功实施和完成COBRE研究项目。 COBRE导师Vivek R博士Nerurkar负责监督核心服务的使用情况，并全面负责有效管理COBRE技术支持资源，指导该核心。 COBRE技术支持核心主要位于RCMI-NCRR支持的逆转录病毒学研究实验室（RRL）内。 通过利用现有基础设施和进一步扩大现有设施，预计将尽量减少服务和设备的重复。 此外，COBRE项目将通过利用昂贵的设备以及在过去13年中在NIH支持下开发和维持的技术进步来有效地服务。 这种杠杆作用的一个例子是立即获得流式细胞仪，流式分选仪，faxitron，闪烁计数器，磷光成像仪，细胞活力分析仪和设备齐全和认证的BSL-3设施。 此外，由非COBRE基金支持的RRL人员具有进行传染病研究的经验。 据设想，这些人员将构成直接的关键核心，在技术和科学上进一步协助COBRE调查人员开发他们的研究项目。 COBRE技术支持核心配备一名全职采访员和一名兼职分子生物学家、病毒学家、生物信息学家、研究助理/生物信息学和流式细胞仪。 核心方案包括三项主要技术支助服务： + 分子生物学和免疫学核心设施 + 生物统计学和生物信息学核心设施 + BSL-3安全壳设施 自2006年1月以来，分子生物学和免疫学以及生物统计学和生物信息学的核心设施从Leahi医院和夏威夷大学马诺阿分校（UHM）主校区搬迁到全新的John A.在Kakaako的Burns医学院生物科学大楼（BSB），COBRE核心的使用量急剧增加。 250 sq.英尺BSL-3封闭设施仍位于Leahi医院。 COBRE核心主任Vivek R. Nerurkar和COBRE PI的Allison Imrie和Guliz Erdem博士位于BSB三楼的COBRE核心设施附近。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims: Improve research competitiveness by enhancing the capacity for mentoring and expanding the capability of the technical support infrastructure for infectious disease research. A vital part of the Pacific Center for Emerging Infectious Diseases Research is the Technical Support Core, which provides specific services and optimizes specific protocols to facilitate the successful implementation and completion of the COBRE Research Projects. The COBRE Mentor, Dr. Vivek R. Nerurkar, who oversees the utilization of core services and has overall responsibility for efficiently and effectively managing COBRE technical support resources, directs this Core. The COBRE Technical Support Core principally resides within the RCMI-NCRR supported Retrovirology Research Laboratory (RRL). By utilizing the existing infrastructure and further expanding the existing facility, it is envisioned that duplication of services and equipment will be minimized. Moreover, the COBRE projects will be efficiently served by leveraging access to expensive equipment as well as technological advances that were developed and sustained with NIH support over the past 13 years. One example of such leverage is the immediate access to a flow cytometer, flow sorter, faxitron, scintillation counter, phosphorimager, cell-viability analyzer and the fully equipped and certified BSL-3 facility. Moreover, personnel within the RRL who are supported by non-COBRE funds, have experience in conducting infectious diseases research. It is envisioned that these personnel who form a immediate critical core, will further assist the COBRE investigators technically and scientifically in developing their research projects. One full-time Interviewer and one each part-time Molecular Biologist, Virologist, Bioinformatician, Research Assistant/Bioinformatics, and Flow Cytometrist, staff the COBRE Technical Support Core. The Core consists of three principal technical support services: + Molecular Biology and Immunology Core Facility + Biostatistics and Bioinformatics Core Facility + BSL-3 Containment Facility Since January 2006 when the Molecular Biology and Immunology and the Biostatistics and Bioinformatics core facilities were relocated from the Leahi Hospital and the University of Hawaii at Manoa (UHM) main campus to the 3rd floor of the brand new John A. Burns School of Medicine, Biosciences Building (BSB) in Kakaako, the usage of COBRE cores has dramatically increased. The 250 sq. ft. BSL-3 Containment Facility is still located at the Leahi Hospital. Laboratories of COBRE Core Director Dr. Vivek R. Nerurkar and COBRE PI's Drs. Allison Imrie and Guliz Erdem are located in very close proximity of the COBRE Core Facility on the 3rd floor of the BSB.