Exploratory-Project 1

探索性项目 1

• 批准号: 10675043
• 负责人: Jose Arturo Bauermeister
• 金额: $ 13.33万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675043
• 关键词: Address; Adolescent; Adoption; Adult; Affect; Age; Behavior; Bisexual; Caring; Clinical; Data; Development; Discrimination; Evaluation; Evidence based intervention; Family; Feeling suicidal; Female; Friends; Future; Gays; General Population; Goals; HIV prevention trial; Health; Heterosexuals; Individual; Intervention; Learning; Lesbian Gay Bisexual Transgender Queer; Licensing; Life; Mental Health; Modeling; Outcome; Participant; Persons; Philadelphia; Predictive Factor; Protocols documentation; Randomized; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Recording of previous events; Reporting; Research; Resources; Risk; Risk Factors; Safety; Same-sex; Sampling; Series; Sexuality; Social Environment; Social isolation; Social support; Suicide; Suicide attempt; Suicide prevention; Testing; Training; Youth; aged; arm; biopsychosocial; clinically significant; comparison control; coping; depressive symptoms; design; effectiveness/implementation design; efficacy outcomes; efficacy trial; emerging adult; emerging adulthood; ethnic diversity; evidence base; experience; high risk; implementation framework; implementation intervention; implementation outcomes; implementation research; improved; innovation; marginalization; men; mobile application; motivational enhancement therapy; peer coaching; peer support; pilot test; population based; primary outcome; programs; prospective; racial diversity; recruit; reducing suicide; secondary outcome; sexual minority; skills; social stigma; stressor; suicidal; suicidal behavior; suicidal risk; telehealth; treatment arm; willingness; young man

Emerging adult gay, bisexual, and same-sex attracted men (EAGBM; ages 18-24) are vulnerable to unique sexuality-related stressors that increase risk for suicidal ideation and behaviors. Unique risk factors predict suicidal ideation and attempts in EAGBM, yet there are few targeted interventions to reduce suicide risk in EAGBM by improving social support, coping, and positive affect. While evidence-based interventions like the safety planning intervention (SPI) significantly reduce suicide risk, research indicates that individuals struggle to use the safety plan in suicidal crises. Thus, we propose to examine a mobile application (Supporting Transitions to Adulthood and Reducing Suicide; STARS) that leverages peer mentoring and support to ensure that EAGBM can implement their safety plan in times of crisis. We will use the ADAPT-ITT Model to adapt an online life skills intervention to reduce suicidal ideation and behaviors among EAGBM. STARS will include suicide prevention content, including safety planning and targeting positive affect, consider cultural factors that may impact the efficacy of safety planning for EAGBM (e.g., access to LGBTQ+ safe spaces), and include supports that promote use of a suicide safety plan. STARS peer mentors will also provide social support, reduce the impact of discrimination, connect youth to safe spaces, and help them overcome obstacles to use their safety plan. Guided by the RE-AIM implementation science framework, we then will pilot test STARS using a Type 1 Effectiveness- Implementation Hybrid Design in a racially/ethnically diverse sample of EAGBM (n=60) living in Philadelphia who report past-month suicidal ideation. Participants will be randomized to an in-person brief, evidence-based safety planning protocol (Control arm) or to safety planning plus access to STARS (Intervention arm). We will follow participants over six months, with evaluations at 2, 4, and 6 months. Consistent with our Type 1 design, we will prioritize preliminary efficacy outcomes (suicidal ideation and behavior) and hypothesized mechanisms of change (coping with discrimination, social support, positive affect) needed to estimate critical parameters for a future trial as our primary outcomes. We also will assess key implementation indicators in both arms (participants: willingness and adoption of safety plan intervention or STARS; staff: experiences adapting and delivering the program) as secondary outcomes. Our Specific Aims are (1) To conduct a systematic suicide prevention adaptation of iREACH (“STARS”) that incorporates safety planning content and targets coping, social support, and positive affect using the ADAPT-ITT framework; (2) To examine preliminary efficacy (suicidal ideation and behaviors) and mechanisms of action of STARS, relative to our control condition (safety planning protocol alone), using a prospective RCT design, and (3) using RE-AIM metrics, to examine whether STARS has preliminary evidence for impacting intervention implementation outcomes among EAGBM compared to the control arm. This Exploratory Project will identify the potential clinical utility of STARS for suicide prevention in a vulnerable, often marginalized, population based on key parameters needed to inform a future efficacy trial.

新兴成年同性恋、双性恋和同性吸引男性（EAGBM； 18-24岁）容易受到独特的影响