South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和压力信号方面的作用
基本信息
- 批准号:10674956
- 负责人:
- 金额:$ 113.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AbbreviationsAccountabilityAchievementAdvisory CommitteesAnalytical BiochemistryAreaAutomobile DrivingAwardBioenergeticsBiologyBiomedical ResearchBiotechnologyCancer CenterCardiovascular DiseasesCellsCenters of Research ExcellenceCollaborationsComplementCore FacilityDiabetes MellitusDisciplineDiseaseDrug AddictionEconomicsEngineeringEquilibriumEquipmentExtramural ActivitiesFacultyFinancial SupportFosteringFundingGastrointestinal AgentsGastrointestinal DiseasesGoalsGrantGrowthHealthHomeostasisHumanHuman PathologyImageIndividualInfrastructureInstitutionInterdisciplinary StudyInterventionMalignant NeoplasmsMass Spectrum AnalysisMedicalMedicineMentorsMetabolic dysfunctionMissionModelingMolecularMusculoskeletalNational Institute of General Medical SciencesNeurodegenerative DisordersOrganismOxidantsOxidation-ReductionOxidative PhosphorylationOxidative StressOxygenPaperPathologicPathway interactionsPeer ReviewPhasePilot ProjectsPositioning AttributeProteomicsPublished CommentPublishingRecoveryResearchResearch InfrastructureResearch PersonnelResource SharingResourcesRoleScientific Advances and AccomplishmentsSecureServicesSignal TransductionSmall Business Innovation Research GrantSmall Business Technology Transfer ResearchSourceSouth CarolinaStressTalentsTeacher Professional DevelopmentTherapeuticTissuesToxic effectTrainingTranslational ResearchUnited States National Institutes of HealthUniversitiesWorkforce Developmentbasecareercollaborative environmentcollegecommercial applicationcostdesignexperiencefaculty supporthuman diseaseimaging capabilitiesimprovedinfrastructure developmentmass spectrometric imagingmembermicroscopic imagingmulti-photonmultidisciplinarynew technologynoveloutreachprogramsrecruitsuccesstargeted treatmenttranslational goalultra high resolution
项目摘要
Overall – Abstract
With Phase III COBRE support, the South Carolina Center in Oxidants, Redox Balance, and Stress Signaling
(Redox COBRE) at the Medical University of South Carolina (MUSC) will complete its transition to long-term
sustainability as a nationally competitive multidisciplinary research program in redox pathobiology. During
Phases I and II, our Redox COBRE was successful in its efforts to (i) expand the critical mass of funded
investigators at MUSC studying the causal role of redox pathways and metabolic dysfunction in a wide range of
human pathologies (cancer, cardiovascular and neurodegenerative diseases, diabetes, gastrointestinal
disorders and drug addiction) and (ii) develop advanced scientific core resources offering a broad range of
capabilities for investigating the biologically significant effects of oxidative stress. Our current core membership
comprises 44 senior and junior faculty members that have received more than $51 million in awards since the
program’s inception. To date, the Redox COBRE has mentored a total of 20 target faculty (junior investigators +
pilot project-supported PIs). Of these individuals, 10 have been promoted and 16 have been retained at our
institution. As a group, these faculty members have published more than 250 peer-reviewed papers and secured
56 extramural grant awards (including 31 NIH grants (PI role) of which 16 are R01 awards and 8 are SBIR/STTR-
supported start-ups). The major components of this Phase III proposal are: (1) an Administrative Core providing
organizational, coordinating, fiscal and accountability functions; (2) an Analytical Redox Core delivering
analytical biochemistry services for quantification of redox-sensitive molecule abundance and redox-based
changes in cellular homeostasis; (3) a Proteomics Core that offers state-of-the-art mass spectrometry (MS) and
MS-imaging capabilities; (4) a Cell & Molecular Redox Imaging Core that provides cell and tissue-based
confocal, multiphoton and super-resolution microscopic imaging; and (5) a Pilot Projects Program (PPP) that
fosters research endeavors utilizing Center resources and facilitates collaborations with Redox COBRE
members. Towards our objective of becoming a stand-alone Center of Redox Biology and Signaling (abbreviated
to “Redox Center”), we will build upon our substantial scientific and institutional achievements, to: (Aim 1)
enhance the function and efficiencies of our scientific cores, achieving optimal positioning to serve Center
thematic and translational goals and achieve/ maintain sustainability; (Aim 2) leverage the PPP to grow center
membership and promote the importance of translational redox signaling research in the context of human
disease; (Aim 3) develop the research portfolio and connections between the Redox COBRE and other IDeA
programs to establish ourselves as a national presence coalescing various disciplines and areas of expertise.
Thus, we are seeking to establish a strategic position for long-term success as an emergent, University-
designated Redox Center that will be one of few national resources for investigators to utilize or develop new
technologies, therapeutics and interventions targeting pathological redox pathways.
总体-摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kenneth D. Tew其他文献
Glutathione S-transferases and S-glutathionylation in cancer
- DOI:
10.1016/j.biopha.2008.07.061 - 发表时间:
2008-10-01 - 期刊:
- 影响因子:
- 作者:
Kenneth D. Tew - 通讯作者:
Kenneth D. Tew
Analysis of glyoxalase-I from normal and tumor tissue from human colon.
对人类结肠正常组织和肿瘤组织中的乙二醛酶-I 进行分析。
- DOI:
10.1016/0925-4439(93)90074-b - 发表时间:
1993 - 期刊:
- 影响因子:0
- 作者:
Sulabha Ranganathan;Kenneth D. Tew - 通讯作者:
Kenneth D. Tew
<em>S</em>-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide
- DOI:
10.1016/j.bbacli.2014.08.003 - 发表时间:
2014-12-01 - 期刊:
- 影响因子:
- 作者:
Christina L. Grek;Leticia Reyes;Danyelle M. Townsend;Kenneth D. Tew - 通讯作者:
Kenneth D. Tew
The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione.
苯丁酸氮芥与谷胱甘肽的自发反应和谷胱甘肽 S-转移酶介导的反应。
- DOI:
- 发表时间:
1990 - 期刊:
- 影响因子:16.2
- 作者:
P. Ciaccio;Kenneth D. Tew;Frank P. LaCreta - 通讯作者:
Frank P. LaCreta
Plasma Protein Biomarkers as Indicators of Pharmacokinetics and Pharmacodynamics in the Development of Novel Cancer Drugs
- DOI:
10.1016/j.biopha.2009.04.026 - 发表时间:
2009-06-01 - 期刊:
- 影响因子:
- 作者:
Kenneth D. Tew - 通讯作者:
Kenneth D. Tew
Kenneth D. Tew的其他文献
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{{ truncateString('Kenneth D. Tew', 18)}}的其他基金
South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和压力信号方面的作用
- 批准号:
10798895 - 财政年份:2021
- 资助金额:
$ 113.25万 - 项目类别:
South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和压力信号方面的作用
- 批准号:
10854099 - 财政年份:2021
- 资助金额:
$ 113.25万 - 项目类别:
South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和压力信号方面的作用
- 批准号:
10460360 - 财政年份:2021
- 资助金额:
$ 113.25万 - 项目类别:
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和应激信号传导中的作用
- 批准号:
8531291 - 财政年份:2011
- 资助金额:
$ 113.25万 - 项目类别:
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和应激信号传导中的作用
- 批准号:
8359562 - 财政年份:2011
- 资助金额:
$ 113.25万 - 项目类别:
South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和压力信号方面的作用
- 批准号:
9341341 - 财政年份:2011
- 资助金额:
$ 113.25万 - 项目类别:
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING
南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和应激信号传导中的作用
- 批准号:
8323219 - 财政年份:2011
- 资助金额:
$ 113.25万 - 项目类别:
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