SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING

这个Cobre项目寻求将南卡罗来纳医科大学在氧化剂、氧化还原平衡和压力信号方面现有专业知识的个人聚集在一起。我们的长期计划是在南卡罗来纳州发展一个这一科学学科或专注于这一科学领域的卓越中心。为此，我们建立了一个基础设施，将为五名目标教员提供一个指导环境，他们的研究兴趣包括钙蛋白酶和糖尿病信号通路、线粒体中的氧化途径、活性氧(ROS)和氮(RNS)物种以及癌症启动中的过氧化还原蛋白、ROS/RNS以及神经细胞死亡的未展开蛋白反应和氧化途径。他们的项目提供了跨学科的机会，并得到了蛋白质组学、代谢组学和细胞和分子成像三个科学核心的支持。中心假说是氧化还原调节通路对癌症、衰老、糖尿病、炎症和神经变性等疾病的病理生物学有重要影响。行政核心将促进包括业务管理、教师发展、指导和计划规划以及可持续性在内的大量职能。我们已经任命了监督委员会，包括指导、内部顾问和外部顾问。后两个群体包括在所选学科拥有广泛的科学专业知识和丰富的指导经验的个人。该项目的未来发展还将得到南加州大学的财政支持，以及创建新的和翻新的空间，以允许更多具有互补专业知识的教员招聘

This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise