SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING

这个COBRE项目旨在汇集南卡罗来纳医科大学现有的氧化剂，氧化还原平衡和压力信号方面的专业知识。我们的长期计划是在南卡罗来纳建立这一科学学科的卓越中心。为此，我们已经建立了一个基础设施，将为五名目标教师提供一个指导环境，他们的研究兴趣包括钙和糖尿病信号通路，线粒体氧化通路，活性氧（ROS）和氮（RNS）物种和癌症起始的过氧化物还毒素，ROS/RNS和未折叠的蛋白质反应和神经元细胞死亡的氧化通路。他们的项目提供了跨学科的机会，并得到了蛋白质组学、代谢组学和细胞与分子成像三个科学核心的支持。核心假设是氧化还原调控通路对癌症、衰老、糖尿病、炎症和神经变性等疾病的病理生物学有显著影响。行政核心将促进多种功能，包括业务管理、教师发展、指导、项目规划和可持续性。我们已经任命了包括指导、内部顾问和外部顾问在内的监督委员会。后两组包含在所选学科中具有广泛的科学专业知识和丰富的指导经验的个人。该计划的未来发展也得到了MUSC的财政支持，并创造了新的和翻新的空间，这将允许额外的教师招聘具有互补的专业知识

This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise