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SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING

南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和应激信号传导中的作用

基本信息

批准号：
8323219
负责人：
Kenneth D. Tew
金额：
$ 218.17万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8323219
关键词：
Aging Area Award Biological Biomedical Research Businesses Calpain Cardiovascular Diseases Cell Death Cells Centers of Research Excellence Collaborations Cytoprotection Development Diabetes Mellitus Discipline Disease Environment Equilibrium Etiology Faculty Fellowship Fostering Funding Future Goals Grant Growth and Development function Human Pathology Individual Inflammation Injury Ischemia Joints Journals Laboratories Laboratory Research Link Malignant Neoplasms Medical Mentors Mentorship Mitochondria Molecular Motivation Nerve Degeneration Neurodegenerative Disorders Neurosciences Nitrogen Outcome Oxidants Oxidation-Reduction Oxidative Stress Oxygen Participant Pathology Pathway interactions Pharmaceutical Preparations Pharmacologic Substance Pharmacology Pharmacy facility Positioning Attribute Post-Translational Protein Processing Postdoctoral Fellow Program Development Proteins Proteomics Radiation Recording of previous events Recruitment Activity Reperfusion Therapy Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Proposals Research Support Research Technics Resources Science Scientist Signal Pathway Signal Transduction Source South Carolina Stress Therapeutic Training United States National Institutes of Health Universities Xenobiotics cancer initiation carcinogenesis career career development cellular imaging college doctoral student drug development drug discovery experience gene therapy graduate student interest member metabolomics molecular imaging neuron loss novel therapeutics pre-doctoral programs research and development response small molecule success toxicant

项目摘要

This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise

这个COBRE计划旨在将南卡罗来纳州医科大学现有的氧化剂，氧化还原平衡和压力信号方面的专业知识汇集在一起。我们的长期计划是在南卡罗来纳州发展一个卓越的中心，在这个科学学科或与这个科学的重点。为此，我们已经构建了一个基础设施，将提供一个指导的环境，为五个目标教师与钙蛋白酶和糖尿病信号通路，线粒体中的氧化途径，活性氧（ROS）和氮（RNS）物种和过氧化物酶在癌症的启动，ROS/RNS和未折叠的蛋白质反应和神经元细胞死亡的氧化途径的研究兴趣。他们的项目提供了跨学科的机会，并得到蛋白质组学，代谢组学和细胞与分子成像三个科学核心的支持。核心假设是氧化还原调节途径对疾病如癌症、衰老、糖尿病、炎症和神经变性的病理生物学有显著影响。行政核心将促进过多的功能，包括业务管理，教师发展，指导和计划规划和可持续性。我们任命了监督委员会，包括指导委员会、内部顾问委员会和外部顾问委员会。后两个小组包括在所选学科中具有广泛科学知识和丰富指导经验的个人。该计划的未来发展也得到了MUSC的财政支持，并创造了新的和翻新的空间，这将允许额外的教师招聘补充专业知识