SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING

南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和应激信号传导中的作用

• 批准号: 8359562
• 负责人: Kenneth D. Tew
• 金额: $ 215.29万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359562
• 关键词: Aging; Businesses; Calpain; Centers of Research Excellence; Development; Diabetes Mellitus; Discipline; Disease; Environment; Equilibrium; Faculty; Funding; Future; Grant; Individual; Inflammation; Malignant Neoplasms; Medical; Mentors; Mitochondria; National Center for Research Resources; Nerve Degeneration; Nitrogen; Oxidants; Oxidation-Reduction; Oxygen; Pathway interactions; Principal Investigator; Program Development; Proteins; Proteomics; Research; Research Infrastructure; Resources; Signal Pathway; Signal Transduction; Source; South Carolina; Stress; United States National Institutes of Health; Universities; cancer initiation; cellular imaging; cost; experience; interest; member; metabolomics; molecular imaging; neuron loss; programs; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise.

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